Abstract
Introduction: We compared pancreatic blood flow (PBF) measured by perfusion CT with deconvolution method and Laser Doppler Flow (LDF) to determine whether uncollected contrast material from the pancreas affects measurement of perfusion CT, using porcine pancreatitis model (n = 7). Materials and Methods: The pancreas was divided into head and tail. We arranged that PBF of tail was circulated by single input/output vessel. Ischemic pancreatitis was induced to tail, shutting off input/output vessel for 30 min. PBF was measured both by perfusion CT with deconvolution method and LDF, during the overall course. We calculated uncollected ratio of contrast material, assuming area-under-curve differences between the input and output vessels correspond to uncollected. Results: tail PBF measured by perfusion CT with deconvolution was significantly correlated with LDF, despite of pancreatitis (P < 0.05). The uncollected ratio was 19 %. Discussion: Although the uncollected ratio was not few, result of perfusion CT was significantly related with LDF.
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Miles, K.A., Griffiths, M.R.: Perfusion CT: a worthwhile enhancement? Br. J. Radiol. 76, 220–231 (2003)
Tsuji, Y., Takahashi, N., Tsutomu, C.: Pancreatic perfusion CT in early stage of severe acute pancreatitis. Int J Inflam. 2012, 497386 (2012)
Tsuji, Y., Yamamoto, H., Yazumi, S., Watanabe, Y., Matsueda, K., Yamamoto, H., Chiba, T.: Perfusion computerized tomography can predict pancreatic necrosis in early stages of severe acute pancreatitis. Clin Gastroenterol Hepatol. 5, 1484–1492 (2007)
Sahani, D.V., Holalkere, N.S., Kambadakone, A., Matthes, K., Mino-Kenudson, M., Brugge, W.R.: Role of computed tomography perfusion in the evaluation of pancreatic necrosis and pancreatitis after endoscopic ultrasound-guided ablation of the pancreas in a porcine model. Pancreas 38, 775–781 (2009)
Axel, L.: Tissue mean transit time from dynamic computed tomography by a simple deconvolution technique. Invest. Radiol. 18, 94–99 (1983)
Beger, H.G., Warshaw, A.L., Büchler, M.W., Kozarek, R.A., Lerch, M.M., Neoptolemos, J.P., Shiratori, K., Whitcomb, D.C., Rau, B.M.: The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery, 2nd edn. Blackwell Publishing, Oxford (2009)
Bradley, E.L., 3rd.: A clinically based classification system for acute pancreatitis. In: Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992 (Arch Surg. vol. 128, pp. 586–590) (1993)
Krejci, V., Hiltebrand, L., Banic, A., Erni, D., Wheatley, A.M., Sigurdsson, G.H.: Continuous measurements of microcirculatory blood flow in gastrointestinal organs during acute haemorrhage. Br. J. Anaesth. 84, 468–475 (2000)
Witzigmann, H., Ludwig, S., Armann, B., Gäbel, G., Teupser, D., Kratzsch, J., Pietsch, U.C., Tannapfel, A., Geissler, F., Hauss, J., Uhlmann, D.: Endothelin(A) receptor blockade reduces ischemia/reperfusion injury in pig pancreas transplantation. Ann. Surg. 238, 264–274 (2003)
Schmidt, J., Rattner, D.W., Lewandrowski, K., Compton, C.C., Mandavilli, U., Knoefel, W.T., Warshaw, A.L.: A better model of acute pancreatitis for evaluating therapy. Ann. Surg. 215, 44–56 (1992)
Eastwood, J.D., Lev, M.H., Azhari, T., Lee, T.Y., Barboriak, D.P., Delong, D.M., Fitzek, C., Herzau, M., Wintermark, M., Meuli, R., Brazier, D., Provenzale, J.M.: CT perfusion scanning with deconvolution analysis: pilot study in patients with acute middle cerebral artery stroke. Radiology 222, 227–236 (2002)
Kishimoto, M., Tsuji, Y., Katabami, N., Shimizu, J., Lee, K.J., Iwasaki, T., Miyake, Y., Yazumi, S., Chiba, T., Yamada, K.: Measurement of canine pancreatic perfusion using dynamic computed tomography: influence of input-output vessels on deconvolution and maximum slope methods. Eur. J. Radiol. 77, 175–181 (2011)
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Tsuji, Y., Yamada, K., Kisimoto, M., Yazumi, S., Isoda, H., Chiba, T. (2014). Pancreatic Blood Flow Measurements in the Pig Pancreatitis Model Using Perfusion CT with Deconvolution Method. In: Yoshida, H., Näppi, J., Saini, S. (eds) Abdominal Imaging. Computational and Clinical Applications. ABD-MICCAI 2014. Lecture Notes in Computer Science(), vol 8676. Springer, Cham. https://doi.org/10.1007/978-3-319-13692-9_9
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DOI: https://doi.org/10.1007/978-3-319-13692-9_9
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