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Feasibility of Single-Input Tracer Kinetic Modeling with Continuous-Time Formalism in Liver 4-Phase Dynamic Contrast-Enhanced CT

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Abdominal Imaging. Computational and Clinical Applications (ABD-MICCAI 2014)

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 8676))

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Abstract

The modeling of tracer kinetics with use of low-temporal-resolution data is of central importance for patient dose reduction in dynamic contrast-enhanced CT (DCE-CT) study. Tracer kinetic models of the liver vary according to the physiologic assumptions imposed on the model, and they can substantially differ in the ways how the input for blood supply and tissue compartments are modeled. In this study, single-input flow-limited (FL), Tofts-Kety (TK), extended TK (ETK), Hayton-Brady (HB), two compartment exchange (2CX), and adiabatic approximation to the tissue homogeneity (AATH) models were applied to the analysis of liver 4-phase DCE-CT data with fully continuous-time parameter formulation, including the bolus arrival time. The bolus arrival time for the 2CX and AATH models was described by modifying the vascular transport operator theory. Initial results indicate that single-input tracer kinetic modeling is feasible for distinguishing between hepatocellular carcinoma and normal liver parenchyma.

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Acknowledgments

This study was supported in part by grant CA187877 from the National Cancer Institute at the National Institutes of Health.

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Authors and Affiliations

  1. 3D Imaging Research, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 25 New Chardon St., Suite 400C, Boston, MA, 02114, USA

    Sang Ho Lee & Hiroyuki Yoshida

  2. Division of Abdominal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, 55 Fruit St., Boston, MA, 02114, USA

    Koichi Hayano

  3. Department of Radiology, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan

    Yasuji Ryu

Authors
  1. Sang Ho Lee
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  2. Yasuji Ryu
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  3. Koichi Hayano
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  4. Hiroyuki Yoshida
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Corresponding author

Correspondence to Sang Ho Lee .

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Editors and Affiliations

  1. 3D Imaging Research ,Dept of Radiology, Harvard Medical School , Massachusetts General Hospital, Boston, Massachusetts, USA

    Hiroyuki Yoshida

  2. 3D Imaging Research, Dept of Radiology, Harvard Medical School , MA General Hospital, Boston, Massachusetts, USA

    Janne J. Näppi

  3. Department of Radiology, Harvard Medical School , MA General Hospital, Boston, Massachusetts, USA

    Sanjay Saini

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© 2014 Springer International Publishing Switzerland

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Lee, S.H., Ryu, Y., Hayano, K., Yoshida, H. (2014). Feasibility of Single-Input Tracer Kinetic Modeling with Continuous-Time Formalism in Liver 4-Phase Dynamic Contrast-Enhanced CT. In: Yoshida, H., Näppi, J., Saini, S. (eds) Abdominal Imaging. Computational and Clinical Applications. ABD-MICCAI 2014. Lecture Notes in Computer Science(), vol 8676. Springer, Cham. https://doi.org/10.1007/978-3-319-13692-9_6

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  • DOI: https://doi.org/10.1007/978-3-319-13692-9_6

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-13691-2

  • Online ISBN: 978-3-319-13692-9

  • eBook Packages: Computer ScienceComputer Science (R0)

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