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The Importance of MicroRNAs in Rheumatoid Arthritis

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MicroRNAs and Other Non-Coding RNAs in Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory disease that is triggered by yet unknown mechanisms, leading to chronic inflammation of the joints. Multiple cell types contribute to the pathogenesis of the disease, especially hematopoietic cells such as macrophages, T and B cells, as well as synovial fibroblasts [1]. Ultimately, synovial inflammation leads to damage to the affected joint, resulting in the fact that RA is the most important cause of disability worldwide. This has spurred tremendous efforts in arthritis research, leading to the development of novel therapies to treat the disease. Despite the advances in the field, there are still a great number of patients not responding to current therapeutic regimens, and, most importantly, the cause of the disease has not been elucidated yet. In this review, we will discuss the possible role of microRNAs in the pathogenesis of RA.

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Authors and Affiliations

  1. Division of Rheumatology, Medical University of Vienna, Vienna, Austria

    Victoria Saferding, Eliana Goncalves-Alves & Stephan Blüml

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  1. Victoria Saferding
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  2. Eliana Goncalves-Alves
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  3. Stephan Blüml
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Correspondence to Victoria Saferding .

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Editors and Affiliations

  1. Respiratory Research, Department of Medicine, Royal College of Surgeon in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland

    Catherine M. Greene

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Saferding, V., Goncalves-Alves, E., Blüml, S. (2015). The Importance of MicroRNAs in Rheumatoid Arthritis. In: Greene, C. (eds) MicroRNAs and Other Non-Coding RNAs in Inflammation. Progress in Inflammation Research. Springer, Cham. https://doi.org/10.1007/978-3-319-13689-9_8

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  • DOI: https://doi.org/10.1007/978-3-319-13689-9_8

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-13688-2

  • Online ISBN: 978-3-319-13689-9

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