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John H. Sipple

1930–

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Surgical Endocrinopathies

Abstract

Multiple endocrine neoplasia type 2A (Sipple syndrome) was first described by John H. Sipple in 1961. He encountered the index patient as a third-year medical resident, established an association between thyroid cancer and pheochromocytoma through meticulous research into the literature, and published a case report identifying a syndrome named after him.

Editors’ Note: Much of the source material for this excellent chapter came from direct interviews that Dr. Sugg held with Dr. Sipple himself.

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References

  1. Sipple JH. The association of pheochromocytoma with carcinoma of the thyroid gland. Am J Med. 1961;31:163–6.

    Article  Google Scholar 

  2. Sipple JH. Multiple endocrine neoplasia type 2 syndromes: historical perspectives. Henry Ford Hospital Med J. 1984;32(4):219–21.

    CAS  Google Scholar 

  3. Hazard JB, Hawk WA, Crile G Jr. Medullary (solid) carcinoma of the thyroid; a clinicopathologic entity. J Clin Endocrinol Metab. 1959;19(1):152–61.

    Article  CAS  PubMed  Google Scholar 

  4. Schimke RN, et al. Syndrome of bilateral pheochromocytoma, medullary thyroid carcinoma and multiple neuromas. A possible regulatory defect in the differentiation of chromaffin tissue. New Engl J Med. 1968;279(1):1–7.

    Article  CAS  PubMed  Google Scholar 

  5. Carney JA. Familial multiple endocrine neoplasia: the first 100 years. Am J Surg Pathol. 2005;29(2):254–74.

    Article  PubMed  Google Scholar 

  6. Cushman P, Jr. Familial endocrine tumors; report of two unrelated kindred affected with pheochromocytomas, one also with multiple thyroid carcinomas. Am J Med. 1962;32:352–60.

    Article  PubMed  Google Scholar 

  7. Manning PCJ, et al. Pheochromocytoma, hyperparathyroidism and thyroid carcinoma occurring coincidentally. Report of a case. New Engl J Med. 1963;168:68–72.

    Article  Google Scholar 

  8. Mulligan LM, et al. Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A. Nature. 1993;363(6428):458–60.

    Article  CAS  PubMed  Google Scholar 

  9. Hughes JM, et al. The Sipple syndrome: from clinical description to genetic analysis in the index family. Endocrinologist. 1996;6(6):427–30.

    Article  Google Scholar 

  10. Neumann HP, et al. Evidence of MEN-2 in the original description of classic pheochromocytoma. New Engl J Med. 2007;357(13):1311–5.

    Article  CAS  PubMed  Google Scholar 

  11. Sisson JC, et al. First description of parathyroid disease in multiple endocrine neoplasia 2A syndrome. Endocr Pathol. 2008;19(4):289–93.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  12. Barker VL, Brines OA. Hyperfunctioning adenoma of an ectopic parathyroid gland. Arch Surg. 1939;39:205–13.

    Article  Google Scholar 

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Correspondence to Sonia L. Sugg MD .

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Sugg, S. (2015). John H. Sipple. In: Pasieka, J., Lee, J. (eds) Surgical Endocrinopathies. Springer, Cham. https://doi.org/10.1007/978-3-319-13662-2_62

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  • DOI: https://doi.org/10.1007/978-3-319-13662-2_62

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-13661-5

  • Online ISBN: 978-3-319-13662-2

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