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Insulinomas

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Surgical Endocrinopathies

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Abstract

Insulinomas, although rare, are the most common functioning neuroendocrine tumors of the pancreas. They are mainly sporadic but can be associated with multiple endocrine neoplasia type 1 (MEN-1). Patients experience neuroglycopenic and adrenergic symptoms which occur with episodes of hypoglycemia. Diagnosis involves a supervised fast, which detects high levels of insulin during hypoglycemia. Once a diagnosis is made, various noninvasive and invasive localization techniques can be utilized to determine the surgical approach and the amount of resection. Surgical management is the main treatment modality, which has a high success rate, obtaining cure in majority of patients leading to a normal life span.

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Authors and Affiliations

  1. Chairman, Department of Surgery, Mount Sinai Beth Israel, First Ave at 16th St., Baird Hall, 16th Floor, Suite 20, 10003, New York, NY, USA

    William B. Inabnet III MD, FACS

  2. Surgery, Mount Sinai Hospital, 10029, New York, NY, USA

    Jane S. Lee

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  1. Jane S. Lee
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  2. William B. Inabnet III MD, FACS
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Correspondence to William B. Inabnet III MD, FACS .

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Editors and Affiliations

  1. Divisions of General Surgery and Surgical Oncology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada

    Janice L. Pasieka

  2. Department of Surgery, Columbia University Medical Center, New York, New York, USA

    James A. Lee

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Lee, J., Inabnet III, W. (2015). Insulinomas. In: Pasieka, J., Lee, J. (eds) Surgical Endocrinopathies. Springer, Cham. https://doi.org/10.1007/978-3-319-13662-2_42

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