Abstract
Aging is characterized by a general decline in physiological function that leads to organism dysfunction, and eventually to death (Proc Natl Acad Sci USA 91(23):10771-10778, 1994). Hearing loss is a common feature of aging and is the third most prevalent chronic health condition in older adults in the United States (Vital Health Stat 10(194):1-89, 1997). Age-related hearing loss (AHL) is a multifactorial sensory disorder caused by aging, heredity and environmental factors such as exposure to noise or ototoxic chemicals/drugs (Hear Res 303:30-38, 2013, 2005; J Pathol 211(2):188–197, 2007). How do these risk factors lead to the pathogenesis of AHL at the molecular level? There is a growing body of evidence suggesting that mitochondrial dysfunction plays a central role in the development of age-related disorders, including AHL (Cell 120(4):483–495, 2005; Annu Rev Genet 39:359–407, 2005; Clin Genet 71:379–391, 2007; Science 309:481–484, 2005; Mech Ageing Dev 131(7-8):480–486, 2010; Proc Natl Acad Sci USA 91(23):10771-10778, 1994; Science 308:1909–1911, 2005). In support of this theory, hearing loss is commonly one of the symptoms of human mitochondrial disorders (Clin Genet 71:379–391, 2007). Yet, specific biochemical pathways of mitochondrial dysfunction in AHL remain poorly characterized. This chapter summarizes what has been learned about the mitochondrial biochemical pathways which are potential targets of AHL, and examines the link between aging, mitochondrial dysfunction, and hearing loss in rodents and humans. We also discuss calorie restriction as a potential intervention to prevent AHL by increasing oxidative stress resistance or enhancing mitochondrial function.
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Kim, MJ., White, K., Walker, L., Han, C., Someya, S. (2015). Age-Related Hearing Loss: Mitochondrial Biochemical Pathways and Molecular Targets. In: Miller, J., Le Prell, C., Rybak, L. (eds) Free Radicals in ENT Pathology. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, Cham. https://doi.org/10.1007/978-3-319-13473-4_13
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DOI: https://doi.org/10.1007/978-3-319-13473-4_13
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