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Alveolar Augmentation: Focus on Growth Factors (BMPs)

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A Tissue Regeneration Approach to Bone and Cartilage Repair

Part of the book series: Mechanical Engineering Series ((MES))

Abstract

Surgical placement of dental implants is governed by the prosthetic design and the morphology and quality of the alveolar bone. Often, implant placement may be difficult, if at all possible, due to alveolar ridge aberrations. In consequence, prosthetically dictated implant positioning commonly entails bone augmentation procedures. We herein discuss the unique biologic potential, the clinical relevance, and perspectives of bone morphogenetic protein (BMP) technologies (focus on rhBMP-2) for alveolar bone augmentation. We also address merits and short-comings of current treatment protocol including bone biomaterials and guided bone regeneration (GBR). In perspective, our studies suggest that BMPs have an unparalleled, dose-dependent potential to augment alveolar bone and in turn support dental implant fixation and functional loading. Inclusion of BMPs for alveolar augmentation to facilitate dental implant fixation may thus not only enhance predictability of existing clinical protocol but radically change current treatment paradigms making conventional “grafting” and GBR procedures altogether obsolete.

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Further Reading

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Acknowledgments

Earlier versions of this text have been published for reviews in journals and book chapters. The text is continuously subject to revisions and updating as new information becomes available in our laboratory. Studies elaborated herein conducted in our laboratories were supported by WL Gore and Associates, Genetics Institute, Wyeth Research, Medtronic, Daewoong Pharmaceuticals and Nobel Biocare.

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Authors and Affiliations

  1. Laboratory for Applied Periodontal & Craniofacial Regeneration (LAPCR), College of Dental Medicine, Georgia Regents University, Augusta, GA, USA

    Ulf M. E. Wikesjö, Cristiano Susin & Jaebum Lee

  2. Departments of Periodontics and Oral Biology, College of Dental Medicine, Georgia Regents University, Augusta, GA, USA

    Ulf M. E. Wikesjö & Cristiano Susin

  3. Center for Clinical and Translational Craniofacial Research (CCTCR), College of Dental Medicine, Augusta, GA, USA

    Cristiano Susin

  4. Department of Periodontics, College of Dental Medicine, Georgia Regents University, Augusta, GA, USA

    Jaebum Lee

Authors
  1. Ulf M. E. Wikesjö
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  2. Cristiano Susin
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  3. Jaebum Lee
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Correspondence to Ulf M. E. Wikesjö .

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Editors and Affiliations

  1. Tissue Engineering and Biomaterials Research Unit, University of Sydney, Sydney, New South Wales, Australia

    Hala Zreiqat

  2. Biomedical Engineering, University of Sydney, Sydney, New South Wales, Australia

    Colin R. Dunstan

  3. Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts, USA

    Vicki Rosen

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Wikesjö, U.M.E., Susin, C., Lee, J. (2015). Alveolar Augmentation: Focus on Growth Factors (BMPs). In: Zreiqat, H., Dunstan, C., Rosen, V. (eds) A Tissue Regeneration Approach to Bone and Cartilage Repair. Mechanical Engineering Series. Springer, Cham. https://doi.org/10.1007/978-3-319-13266-2_7

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