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Cartilage Regeneration Using Induced Pluripotent Stem Cell Technologies

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A Tissue Regeneration Approach to Bone and Cartilage Repair

Part of the book series: Mechanical Engineering Series ((MES))

Abstract

The loss of articular cartilage due to trauma or the degeneration caused by aging can result in debilitating conditions and osteoarthritis, because hyaline cartilage has a poor intrinsic capacity for healing. Articular cartilage defects are currently treated by several procedures, including microfracture and autologous chondrocyte transplantation, although fibrocartilaginous tissue is frequently formed instead of true hyaline cartilage. The development of induced pluripotent stem cells (iPSCs) offers a new cell source that is free of the ethical issues associated with the use of embryonic stem cells. In addition, the methods used to generate iPSCs and their differentiation into chondrocytes have been improved. As another cell source, a method for the direct conversion of fibroblasts to chondrocytes, which can generate hyaline cartilage, is also being developed.

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Authors and Affiliations

  1. Dept. of Cell Growth and Differentiation, Center for IPS Cell Research and Application, Kyoto University, 53 Kawahara-Cho, Shogoin, Sakyo-Ku, Kyoto, 606-8507, Japan

    Noriyuki Tsumaki

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  1. Noriyuki Tsumaki
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Correspondence to Noriyuki Tsumaki .

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Editors and Affiliations

  1. Tissue Engineering and Biomaterials Research Unit, University of Sydney, Sydney, New South Wales, Australia

    Hala Zreiqat

  2. Biomedical Engineering, University of Sydney, Sydney, New South Wales, Australia

    Colin R. Dunstan

  3. Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts, USA

    Vicki Rosen

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Tsumaki, N. (2015). Cartilage Regeneration Using Induced Pluripotent Stem Cell Technologies. In: Zreiqat, H., Dunstan, C., Rosen, V. (eds) A Tissue Regeneration Approach to Bone and Cartilage Repair. Mechanical Engineering Series. Springer, Cham. https://doi.org/10.1007/978-3-319-13266-2_6

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  • DOI: https://doi.org/10.1007/978-3-319-13266-2_6

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