Osteoblasts Derived from Autologous Human Stem Cells to Graft Jawbone Deficiencies

Abstract

Grafting of jaw bone deficiencies is a key step prior to dental rehabilitation and functional restoration. Autologously harvested bone grafts are considered to be the best graft material. The presence of vital cells and its nature makes autologous bone grafts, especially from the iliac crest, an excellent choice over other materials. Unfortunately, the necessity of a second surgical site (donor area) with its accompanying morbidity and post-operative complications often negate the benefits. Human mesenchymal stem cells obtained from bone marrow of the posterior iliac crest in a minimally invasive procedure are used to culture osteoblasts which are then placed in a gel formulation in the deficient areas. This procedure fulfills all the advantages of an autologous bone graft without any of the attendant problems of the surgery and undesirable post-operative sequelae. Clinical treatment cases are shown to highlight the advantage of this treatment modality.