Abstract
The Association between nanotechnology and biomagnetic diagnostic techniques unwrapped a whole new research field that allows us to noninvasively study physiological parameters, such as dynamic perfusion and retention in organs and tissues. By associating the AC Biosusceptometry (ACB) system to magnetic iron oxide nanoparticles doped with manganese, we analyzed circulation time and biodistribution patterns for these particles after 20 minutes of infusion. We found a circulation time of 181±49 s, with major biodistribution to liver, lungs and spleen, given the particles features and the organs morphology. Our results showed the ACB system efficiency on particles dynamic tracing and bloodstream patterns assessments, and suggest the use of less reactive nanoparticles with a higher circulation time in the body.
Keywords
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer International Publishing Switzerland
About this paper
Cite this paper
Próspero, A.G. et al. (2015). Time of Permanence in the Bloodstream and Biodistribution of MnFe2O4 in Rats: Preliminary Results. In: Braidot, A., Hadad, A. (eds) VI Latin American Congress on Biomedical Engineering CLAIB 2014, Paraná, Argentina 29, 30 & 31 October 2014. IFMBE Proceedings, vol 49. Springer, Cham. https://doi.org/10.1007/978-3-319-13117-7_12
Download citation
DOI: https://doi.org/10.1007/978-3-319-13117-7_12
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-13116-0
Online ISBN: 978-3-319-13117-7
eBook Packages: EngineeringEngineering (R0)