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Reagent-Controlled Lithiation–Borylation

Chapter
Part of the Topics in Organometallic Chemistry book series (TOPORGAN, volume 49)

Abstract

This chapter focuses on the stereo-controlled homologation of chiral boronic esters with chiral lithium carbenoid (lithiation–borylation) as a powerful method for the asymmetric synthesis of many complex molecules. It is highlighted that the potential methodology to create multiple contiguous stereogenic centers on “growing” carbon chains.

Keywords

1,2-Metallate rearrangement Boronic esters Stereospecific Homologation Lithiated carbamates Total synthesis 

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.School of ChemistryUniversity of BristolBristolUK

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