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Asymmetric Catalytic Borylation of α,β-Unsaturated Acceptors

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Book cover Synthesis and Application of Organoboron Compounds

Part of the book series: Topics in Organometallic Chemistry ((TOPORGAN,volume 49))

Abstract

Asymmetric β-borylation (conjugate borylation) of α,β-unsaturated acceptors allows the efficient synthesis of chiral organoboron compounds bearing extra functional groups. In the last 8 years, impressive progress has been made regarding this reaction since the first asymmetric report. While copper catalysis has dominated the field of asymmetric borylation due to its high reactivity and selectivity, various metal-catalyzed and metal-free methods have also been developed. The present chapter covers recent developments in asymmetric borylation of α,β-unsaturated compounds while focusing on the substrate scope and enantioselectivity of each catalytic system. In addition, recent achievements of asymmetric borylation conducted in water are briefly presented.

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Acknowledgments

We are grateful for the financial support of the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2013R1A1A2058160).

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Authors and Affiliations

  1. Department of Chemistry and Institute of Basic Science, Sungkyunkwan University, Suwon, 440-746, South Korea

    Sumin Lee & Jaesook Yun

Authors
  1. Sumin Lee
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  2. Jaesook Yun
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Correspondence to Jaesook Yun .

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Editors and Affiliations

  1. Universitat Rovira i Virgili Directora TECAT, Tarragona, Spain

    Elena Fernández

  2. Department of Chemistry, Centre for Sustainable Chemical Processes, Durham, United Kingdom

    Andrew Whiting

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Lee, S., Yun, J. (2015). Asymmetric Catalytic Borylation of α,β-Unsaturated Acceptors. In: Fernández, E., Whiting, A. (eds) Synthesis and Application of Organoboron Compounds. Topics in Organometallic Chemistry, vol 49. Springer, Cham. https://doi.org/10.1007/978-3-319-13054-5_3

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