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Blood Supply of the Optic Nerve Head

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Ocular Vascular Occlusive Disorders

Abstract

Optic nerve head (ONH) circulatory disorders together constitute one of the most important ocular vascular disorders (e.g., anterior ischemic optic neuropathy, glaucomatous optic neuropathy, and optic disc vasculitis). To understand these disorders, a good basic understanding of the blood supply of the ONH is a first essential. I have discussed this at length elsewhere [1, 2], and the following is a brief account.

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References

  1. Hayreh SS. The blood supply of the optic nerve head and the evaluation of it – myth and reality. Prog Retin Eye Res. 2001;20:563–93.

    Article  CAS  PubMed  Google Scholar 

  2. Hayreh SS. Ischemic optic neuropathies. Heidelberg: Springer; 2011. p. 35–78.

    Book  Google Scholar 

  3. Briggs G. Ophthalmographia, sive Oculi ejusque partium descriptio Anatomica. Foan, Hayes, Celeberrimae, Cantab; 1676. p. 28.

    Google Scholar 

  4. Hayreh SS, Vrabec F. The structure of the head of the optic nerve in rhesus monkey. Am J Ophthalmol. 1966;61(1):136–50.

    Article  CAS  PubMed  Google Scholar 

  5. Elschnig A. Der normale Sehnerveneintritt des menschlichen. Auges. Denkschriften der mathematisch-naturwissenschaftlichen Classe der kaiserl Akademie der Wissenschaften, Wein. 1899;70:219–303.

    Google Scholar 

  6. Elschnig A. NormaleAnatomie des Sehnerveneintrittes: zusammenstellungophthalmoskopischer und anatomischerBefunde (AugenärztlicheUnterrichtstafelnfür den akademischen und Selbst-Unterricht). Bern: Kern; 1899. p. 1–24.

    Google Scholar 

  7. Anderson DR. Ultrastructure of the optic nerve head. Arch Ophthalmol. 1970;83(1):63–73.

    Article  CAS  PubMed  Google Scholar 

  8. Roth AM, Foos RY. Surface structure of the optic nerve head. 1. Epipapillary membranes. Am J Ophthalmol. 1972;74(5):977–85.

    Article  CAS  PubMed  Google Scholar 

  9. Kuhnt H. Zur Kenntniss des Sehnerven und der Netzhaut. Albrecht Von Graefes Arch Ophthalmol. 1879;25(3):179–288.

    Article  Google Scholar 

  10. Jacoby E. Über die Neuroglia des Sehnerven. Klin Mbl Augenheilk. 1905;43:129–37.

    Google Scholar 

  11. Hogan MJ, Alvarado JA, Weddell JE. Histology of the human eye. Philadelphia: Saunders; 1971. p. 523, 537, 544, 561, 606.

    Google Scholar 

  12. Anderson DR. Ultrastructure of human and monkey lamina cribrosa and optic nerve head. Arch Ophthalmol. 1969;82(6):800–14.

    Article  CAS  PubMed  Google Scholar 

  13. Bron AJ, Tripathi RC, Tripathy BJ. Optic nerve, Section 15.1. In: Wolff’s anatomy of the Eye and orbit. 8th ed. London: Chapman & Hall; 1997. p. 489–535.

    Google Scholar 

  14. Salzmann M. The nd histology of the human eyeball in the normal state; its development and senescence. Chicago: University of Chicago Press; 1912. p. 94.

    Google Scholar 

  15. Hayreh SS. Structure and blood supply of the optic nerve. In: Heilmann K, Richardson KT, editors. Glaucoma: conceptions of a disease. Stuttgart: Georg Theime Publishers; 1978. p. 78–96.

    Google Scholar 

  16. Hayreh SS. Anatomy and physiology of the optic nerve head. Trans Am Acad Ophthalmol Otolaryngol. 1974;78:OP240–54.

    CAS  PubMed  Google Scholar 

  17. Hayreh SS. Blood supply of the optic nerve head and its role in optic atrophy, glaucoma, and oedema of the optic disc. Br J Ophthalmol. 1969;53(11):721–48.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  18. Hayreh SS. Inter-individual variation in blood supply of the optic nerve head. Doc Ophthalmol. 1985;59:217–46.

    Article  CAS  PubMed  Google Scholar 

  19. Hayreh SS, Revie IH, Edwards J. Vasogenic origin of visual field defects and optic nerve changes in glaucoma. Br J Ophthalmol. 1970;54(7):461–72.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  20. Hayreh SS. Pathogenesis of visual field defects. Role of the ciliary circulation. Br J Ophthalmol. 1970;54(5):289–311.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  21. Hayreh SS, Perkins ES. Clinical and experimental studies on the circulation at the optic nerve head. Proc Wm MacKenzie Centenary symposium on the Ocular Circulation in Health and Disease, Glasgow. London: Kimpton; 1968. p. 71–86.

    Google Scholar 

  22. Ernest JT, Potts AM. Pathophysiology of the distal portion of the optic nerve. II. Vascular relationships. Am J Ophthalmol. 1968;66(3):380–7.

    Article  CAS  PubMed  Google Scholar 

  23. Hayreh SS, Perkins ES. The effects of raised intraocular pressure on the blood vessels of the retina and optic disc. Proc Int Symp Fluorescein Angiography, Albi. Basel: Karger; 1969. p. 323–28.

    Google Scholar 

  24. Henkind P, Levitzky M. Angioarchitecture of the optic nerve. I. The papilla. Am J Ophthalmol. 1969;68(6):979–86.

    Article  CAS  PubMed  Google Scholar 

  25. Levitzky M, Henkind P. Angioarchitecture of the optic nerve. II. Lamina cribrosa. Am J Ophthalmol. 1969;68(6):986–96.

    Article  CAS  PubMed  Google Scholar 

  26. Anderson DR. Vascular supply to the optic nerve of primates. Am J Ophthalmol. 1970;70(3):341–51.

    Article  CAS  PubMed  Google Scholar 

  27. Swietliczko I, David NJ. Fluorescein angiography in experimental ocular hypertension. Am J Ophthalmol. 1970;70(3):351–63.

    Article  CAS  PubMed  Google Scholar 

  28. Theodossiadis GP. Uber die Vaskularisation in der Regio praelaminaris der Papilla optica. [Vascularization in the prelaminar region of the optic papilla]. Klin Monatsbl Augenheilkd. 1971;158(5):646–52.

    CAS  PubMed  Google Scholar 

  29. Hayreh SS. Optic disc changes in glaucoma. Br J Ophthalmol. 1972;56(3):175–85.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  30. Hayreh SS, Baines JA. Occlusion of the posterior ciliary artery. I. Effects on choroidal circulation. Br J Ophthalmol. 1972;56(10):719–35.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  31. Hayreh SS. Colour and fluorescence of the optic disc. Ophthalmologica. 1972;165(2):100–8.

    Article  CAS  PubMed  Google Scholar 

  32. Araki M, Honmura S. The collateral communications of the retinal circulation with the choroidal circulation at the optic nerve head (in Japanese). Nippon Ganka Gakkai Zasshi. 1973;77(10):1557–66.

    CAS  PubMed  Google Scholar 

  33. Yokochi K, Maruyama H, Sodeno Y. Microcirculation of the disc and peripapillary choroid (in Japanese). Nippon Ganka Gakkai Zasshi. 1973;77(10):1534–42.

    CAS  PubMed  Google Scholar 

  34. Evans PY, Shimizu K, Limaye S, Deglin E, Wruck J. Fluorescein cineangiography of the optic nerve head. Trans Am Acad Ophthalmol Otolaryngol. 1973;77(3):OP260–73.

    CAS  PubMed  Google Scholar 

  35. Ito K. Fluorescein angiographic findings of normal optic disc (in Japanese). Nippon Ganka Gakkai Zasshi. 1973;77(10):1543–56.

    CAS  PubMed  Google Scholar 

  36. Hayreh SS. Anterior ischaemic optic neuropathy. I. Terminology and pathogenesis. Br J Ophthalmol. 1974;58(12):955–63.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  37. Hayreh SS. Anterior ischaemic optic neuropathy. II. Fundus on ophthalmoscopy and fluorescein angiography. Br J Ophthalmol. 1974;58(12):964–80.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  38. Shimizu K, Yokochi K, Okano T. Fluorescein angiography of the choroid. Jpn J Ophthalmol. 1974;18:97–108.

    Google Scholar 

  39. Hayreh SS. Segmental nature of the choroidal vasculature. Br J Ophthalmol. 1975;59:631–48.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  40. Hayreh SS. Anterior ischemic optic neuropathy. New York: Springer; 1975.

    Book  Google Scholar 

  41. Araki M. Anatomical study of the vascularization of the optic nerve (in Japanese). Nippon Ganka Gakkai Zasshi. 1975;79(2):101–9.

    CAS  PubMed  Google Scholar 

  42. Ernest JT. Pathogenesis of glaucomatous optic nerve disease. Trans Am Ophthalmol Soc. 1975;73:366–88.

    PubMed Central  CAS  PubMed  Google Scholar 

  43. Anderson DR, Braverman S. Reevaluation of the optic disk vasculature. Am J Ophthalmol. 1976;82(2):165–74.

    Article  CAS  PubMed  Google Scholar 

  44. Schwartz B, Rieser JC, Fishbein SL. Fluorescein angiographic defects of the optic disc in glaucoma. Arch Ophthalmol. 1977;95(11):1961–74.

    Article  CAS  PubMed  Google Scholar 

  45. Shimizu K, Ujiie K. Structure of ocular vessels. New York: Igaku-Shoin; 1978. p. 54, 70–79, 108–124.

    Google Scholar 

  46. Hayreh SS. Anterior ischemic optic neuropathy. Arch Neurol. 1981;38:675–8.

    Article  CAS  PubMed  Google Scholar 

  47. Risco JM, Grimson BS, Johnson PT. Angioarchitecture of the ciliary artery circulation of the posterior pole. Arch Ophthalmol. 1981;99(5):864–8.

    Article  CAS  PubMed  Google Scholar 

  48. Hayreh SS, Chopdar A. Occlusion of the posterior ciliary artery. V. Protective influence of simultaneous vortex vein occlusion. Arch Ophthalmol. 1982;100(9):1481–91.

    Article  CAS  PubMed  Google Scholar 

  49. Hayreh SS. Microangioarchitecture of optic papilla [comment]. Jpn J Ophthalmol. 1989;33(4):519–25.

    CAS  PubMed  Google Scholar 

  50. Fryczkowski AW. Mikrokrzenie w nerwie wzrokowym. III. Blaszka sitowa. [Optic nerve microcirculation. III. Lamina cribrosa]. Klin Oczna. 1991;93(2–3):47–50.

    CAS  PubMed  Google Scholar 

  51. Onda E, Cioffi GA, Bacon DR, Van Buskirk EM. Microvasculature of the human optic nerve. Am J Ophthalmol. 1995;120(1):92–102.

    Article  CAS  PubMed  Google Scholar 

  52. Hayreh SS. Blood supply and vascular disorders of the optic nerve. An Inst Barraquer. 1963;4:7–109.

    Google Scholar 

  53. Hayreh SS. The central artery of the retina. Its role in the blood supply of the optic nerve. Br J Ophthalmol. 1963;47:651–63.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  54. Ducournau D. Systematisation vasculaire de la choroide. Lyon: Association Corporative des Etudiants en Médecine de Lyon; 1979. p. 17–22.

    Google Scholar 

  55. François J, Neetens A. Vascularization of the optic pathway. I. Lamina cribrosa and optic nerve. Br J Ophthalmol. 1954;38(8):472–88.

    Article  PubMed Central  PubMed  Google Scholar 

  56. François J, Neetens A, Collette JM. Vascular supply of the optic pathway. II. Further studies by micro-arteriography of the optic nerve. Br J Ophthalmol. 1955;39(4):220–32.

    Article  PubMed Central  PubMed  Google Scholar 

  57. Hayreh SS. A study of the central artery of the retina in human beings. [Thesis for the Master of Surgery]. India: Panjab University; 1958.

    Google Scholar 

  58. Singh (Hayreh) S, Dass R. The central artery of the retina. II. A study of its distribution and anastomoses. Br J Ophthalmol. 1960;44:280–99.

    Article  Google Scholar 

  59. Hayreh SS. The orbital vessels of rhesus monkeys. Exp Eye Res. 1964;3:16–30.

    CAS  PubMed  Google Scholar 

  60. Fryczkowski AW, Grimson BS, Peiffer Jr RL. Scanning electron microscopy of vascular casts of the human scleral lamina cribrosa. Int Ophthalmol. 1984;7(2):95–100.

    Article  CAS  PubMed  Google Scholar 

  61. Olver JM, Spalton DJ, McCartney AC. Microvascular study of the retrolaminar optic nerve in man: the possible significance in anterior ischaemic optic neuropathy. Eye. 1990;4(Pt 1):7–24.

    Article  PubMed  Google Scholar 

  62. Lieberman MF, Maumenee AE, Green WR. Histologic studies of the vasculature of the anterior optic nerve. Am J Ophthalmol. 1975;82:405–23.

    Article  Google Scholar 

  63. Zhao Y, Li F. Microangioarchitecture of optic papilla. Jpn J Ophthalmol. 1987;31:147–59.

    CAS  PubMed  Google Scholar 

  64. Leber T. Graefe-Saemisch Handbuch der gesamten Augenheilkunde. 2nd ed, vol 2, pt 2. Leipzig: Engelmann; 1903.

    Google Scholar 

  65. Parsons JH. The pathology of the Eye, vol. 3. London: Hodder and Stoughton; 1906. p. 949–50.

    Google Scholar 

  66. Francois J, Neetens A. Vascularization of the optic pathway. III. Study of intra-orbital and intracranial optic nerve by serial sections. Br J Ophthalmol. 1956;40:45–52.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  67. Steele EJ, Blunt MJ. The blood supply of the optic nerve and chiasma in man. J Anat. 1956;90:486–93.

    PubMed Central  PubMed  Google Scholar 

  68. Francois J, Neetans A. The fine angio-architecture of the anterior optic nerve. In: Cant JS, editor. “The optic nerve”, Proc Second Mackenzie symposium. London: Kimpton: 1972. p. 28–39.

    Google Scholar 

  69. Hayreh SS. The optic nerve head circulation in health and disease. Exp Eye Res. 1995;61:259–72.

    Article  CAS  PubMed  Google Scholar 

  70. Hayreh SS. Blood supply of the optic nerve head in health and disease. In: Lambrou GN, Greve EL, editors. Ocular blood flow in glaucoma: means, methods and measurements. Amstelveen: Kugler & Ghedini; 1989. p. 3–54.

    Google Scholar 

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Hayreh, S.S. (2015). Blood Supply of the Optic Nerve Head. In: Ocular Vascular Occlusive Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-12781-1_5

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  • DOI: https://doi.org/10.1007/978-3-319-12781-1_5

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