Skip to main content

Arterial Hypertension and the Eye

  • Chapter
  • First Online:
Book cover Ocular Vascular Occlusive Disorders
  • 2353 Accesses

Abstract

Arterial hypertension is a common systemic disease. In the middle-aged and elderly population, there is a trend toward a rise in blood pressure (BP) which often becomes steeper with age [1]. Systemic mortality and morbidity are markedly higher in hypertensives than in normotensives; for example, hypertensives are seven times as likely to develop stroke as normotensives, four times as likely to have congestive heart failure, three times as likely to have coronary artery disease, and twice as likely to have peripheral arterial disease; and the hypertensive’s risk of total and cardiovascular mortality is twice that of the normotensive [2].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Page LB. Epidemiology of hypertension. In: Genest J, Kuchel O, Hamet P, Cantin M, editors. Hypertension: physiopathology and treatment. 2nd ed. New York: McGraw Hill; 1983. p. 683–99.

    Google Scholar 

  2. Kannel WB, Sorlie P. Hypertension in Framingham. In: Oglesby P, editor. Epidemiology and control of hypertension: papers and discussions from the second International Symposium on the Epidemiology of Hypertension presented September 1974 by the Chicago Heart Association. New York: Stratton Intercontinental Medical Book Corp; 1975. p. 553–92.

    Google Scholar 

  3. Bright R. Cases and observations illustrative of renal disease accompanied with the secretion of albuminous urine. Guys Hosp Rep. 1836;1:338–400.

    Google Scholar 

  4. Liebreich R. Ophthalmoscopic findings in Bright’s disease. Graefes Arch Clin Exp Ophthalmol. 1859;5:265–8.

    Google Scholar 

  5. Garner A, Ashton N, Tripathi R, Kohner EM, Bulpitt CJ, Dollery CT. Pathogenesis of hypertensive retinopathy. An experimental study in the monkey. Br J Ophthalmol. 1975;59:3–44.

    PubMed Central  CAS  PubMed  Google Scholar 

  6. Hayreh SS, Servais GE, Virdi PS, Marcus ML, Rojas P, Woolson RF. Fundus lesions in malignant hypertension. III. Arterial blood pressure, biochemical, and fundus changes. Ophthalmology. 1986;93:45–59.

    CAS  PubMed  Google Scholar 

  7. Hayreh SS, Servais GE, Virdi PS. Fundus lesions in malignant hypertension. IV. Focal intraretinal periarteriolar transudates. Ophthalmology. 1986;93:60–73.

    CAS  PubMed  Google Scholar 

  8. Hayreh SS, Servais GE, Virdi PS. Fundus lesions in malignant hypertension. V. Hypertensive optic neuropathy. Ophthalmology. 1986;93:74–87.

    CAS  PubMed  Google Scholar 

  9. Kishi S, Tso MO, Hayreh SS. Fundus lesions in malignant hypertension II. A pathologic study of experimental hypertensive optic neuropathy. Arch Ophthalmol. 1985;103:1198–206.

    CAS  PubMed  Google Scholar 

  10. Hayreh SS, Servais GE, Virdi PS. Fundus lesions in malignant hypertension. VI. Hypertensive choroidopathy. Ophthalmology. 1986;93:1383–400.

    CAS  PubMed  Google Scholar 

  11. Kishi S, Tso MO, Hayreh SS. Fundus lesions in malignant hypertension I. A pathologic study of experimental hypertensive choroidopathy. Arch Ophthalmol. 1985;103:1189–97.

    CAS  PubMed  Google Scholar 

  12. Hayreh SS, Servais GE. Retinal hemorrhages in malignant arterial hypertension. Int Ophthalmol. 1988;12:137–45.

    CAS  PubMed  Google Scholar 

  13. Hayreh SS. Hypertensive retinopathy. Introduction. Ophthalmologica. 1989;198:173–7.

    CAS  PubMed  Google Scholar 

  14. Hayreh SS, Servais GE, Virdi PS. Retinal arteriolar changes in malignant arterial hypertension. Ophthalmologica. 1989;198:178–96.

    CAS  PubMed  Google Scholar 

  15. Hayreh SS, Servais GE, Virdi PS. Cotton-wool spots (inner retinal ischemic spots) in malignant arterial hypertension. Ophthalmologica. 1989;198:197–215.

    CAS  PubMed  Google Scholar 

  16. Hayreh SS, Servais GE, Virdi PS. Retinal lipid deposits in malignant arterial hypertension. Ophthalmologica. 1989;198:216–29.

    CAS  PubMed  Google Scholar 

  17. Hayreh SS, Servais GE, Virdi PS. Macular lesions in malignant arterial hypertension. Ophthalmologica. 1989;198:230–46.

    CAS  PubMed  Google Scholar 

  18. Hayreh SS. Classification of hypertensive fundus changes and their order of appearance. Ophthalmologica. 1989;198:247–60.

    CAS  PubMed  Google Scholar 

  19. Hayreh SS. Duke-Elder Lecture: Systemic arterial blood pressure and the eye. Eye. 1996;10:5–28.

    PubMed  Google Scholar 

  20. Strandgaard S, Jones JV, MacKenzie ET, Harper AM. Upper limit of cerebral blood flow autoregulation in experimental renovascular hypertension in the baboon. Circ Res. 1975;37:164–7.

    CAS  PubMed  Google Scholar 

  21. Jones JV, Fitch W, MacKenzie ET, Strandgaard S, Harper AM. Lower limit of cerebral blood flow autoregulation in experimental renovascular hypertension in the baboon. Circ Res. 1976;39:555–7.

    CAS  PubMed  Google Scholar 

  22. Hayreh SS, Zimmerman MB, Podhajsky P, Alward WLM. Nocturnal arterial hypotension and its role in optic nerve head and ocular ischemic disorders. Am J Ophthalmol. 1994;117:603–24.

    CAS  PubMed  Google Scholar 

  23. Lüscher TF. The endothelium and cardiovascular disease–a complex relation. N Engl J Med. 1994;330:1081–3.

    PubMed  Google Scholar 

  24. Haefliger IO, Meyer P, Flammer J, Lüscher TF. The vascular endothelium as a regulator of the ocular circulation: a new concept in ophthalmology? Surv Ophthalmol. 1994;39:123–32.

    CAS  PubMed  Google Scholar 

  25. Hayreh SS. Progress in the understanding of the vascular etiology of glaucoma. Curr Opin Ophthalmol. 1994;5:26–35.

    Google Scholar 

  26. Bill A. Blood circulation and fluid dynamics in the eye. Physiol Rev. 1975;55:383–417.

    CAS  PubMed  Google Scholar 

  27. Bill A, Törnquist P, Alm A. Permeability of the intraocular blood vessels. Trans Ophthalmol Soc U K. 1980;100:332–6.

    CAS  PubMed  Google Scholar 

  28. Bill A, Sperber G, Ujiie K. Physiology of the choroidal vascular bed. Int Ophthalmol. 1983;6:101–7.

    CAS  PubMed  Google Scholar 

  29. Boisvert DP, Jones JV, Harper AM. Cerebral blood flow autoregulation to acutely increasing blood pressure during sympathetic stimulation. Acta Neurol Scand Suppl. 1977;64:46–7.

    CAS  PubMed  Google Scholar 

  30. Hayreh SS. Structure and blood supply of the optic nerve. In: Heilmann K, Richardson KT, editors. Glaucoma: conceptions of a disease. Stuttgart: Georg Theime Publishers; 1978. p. 78–96.

    Google Scholar 

  31. Genest J, Kuchel O, Hamet P, Cantin M, editors. Hypertension: physiopathology and treatment. 2nd ed. New York: McGraw Hill; 1983.

    Google Scholar 

  32. Kincaid-Smith P. Malignant hypertension: mechanisms and management. Pharmacol Ther. 1980;9:245–69.

    CAS  PubMed  Google Scholar 

  33. Goldblatt H, Lynch J, Hanzal RF, Summerville WW. Studies on experimental hypertension: I. The production of persistent elevation of systolic blood pressure by means of renal ischemia. J Exp Med. 1934;59:347–79.

    PubMed Central  CAS  PubMed  Google Scholar 

  34. Davis BA, Crook JE, Vestal RE, Oates JA. Prevalence of renovascular hypertension in patients with grade III or IV hypertensive retinopathy. N Engl J Med. 1979;301:1273–6.

    CAS  PubMed  Google Scholar 

  35. Wilson L, Dustan HP, Page IH, Poutasse EF. Diagnosis of renal arterial lesions. Arch Intern Med. 1963;112:270–7.

    CAS  PubMed  Google Scholar 

  36. von Graefe A. Mittheilungen vermischten Inhalts: (1) Beobachtungen über Accommodation bei Linsendefekt, Muskelkrankheiten und Anomalieen der Iris. Albrecht von Graefes Arch Klin Exp Ophthalmol. 1855;2:187–94.

    Google Scholar 

  37. Elschnig A. Die diagnostische und prognostische Bedeutung der Netzhauterkrankungen bei Nephritis. Wien Med Wochenschr. 1904;54:445–52.

    Google Scholar 

  38. Lecorche E. De l’altération de la vision dans la néphrite albumineuse (Maladie de Bright). Thèse de doctorat Médecine Paris: Rignoux, Imprimeur: Faculté de Médecine de Paris; 1858.

    Google Scholar 

  39. Bousseau AJB. Des rétinites secondaires ou symptomatiques (Collection des thèses soutenues à la Faculté de Médecine de Paris. An 1868. tom. 2). Paris: Delahaye; 1868.

    Google Scholar 

  40. Wagener HP. The retinitis of malignant hypertension. Trans Am Ophthalmol Soc. 1927;25:349–80.

    PubMed Central  CAS  PubMed  Google Scholar 

  41. Koyanagi Y. Ueber die Pathogenese der Retinitis nephritica. Klin Monbl Augenheilkd. 1928;80:436–61.

    Google Scholar 

  42. Fuchs E. Ueber Chorioiditis albuminurica. Klin Monbl Augenheilkd. 1930;84:39–52.

    Google Scholar 

  43. Müller H. [The histological picture of allergic choroiditis with allergic nephritis] Das histologische Bild der Chorioiditis allergica bei allergischer Nephritis. Albrecht von Graefes Arch Ophthalmol. 1950;150:58–74.

    Google Scholar 

  44. Klien BA. Ischemic infarcts of the choroid (Elschinig spots). A cause of retinal separation in hypertensive disease with renal insufficiency. A clinical and histopathologic study. Am J Ophthalmol. 1968;66:1069–74.

    CAS  PubMed  Google Scholar 

  45. Morse PH. Elschnig’s spots and hypertensive choroidopathy. Am J Ophthalmol. 1968;66:844–52.

    CAS  PubMed  Google Scholar 

  46. Burian HM. Pigment epithelium changes in arteriosclerotic choroidopathy. Am J Ophthalmol. 1969;68:412–6.

    CAS  PubMed  Google Scholar 

  47. de Venecia G, Wallow I, Houser D, Wahlstrom M. The eye in accelerated hypertension. I. Elschnig’s spots in nonhuman primates. Arch Ophthalmol. 1980;98:913–8.

    PubMed  Google Scholar 

  48. Tso MOM, Jampol LM. Patho-physiology of hypertensive retinopathy. Ophthalmology. 1982;89:1132–45.

    CAS  PubMed  Google Scholar 

  49. de Venecia G, Jampol LM. The eye in accelerated hypertension. II. Localized serous detachments of the retina in patients. Arch Ophthalmol. 1984;102:68–73.

    PubMed  Google Scholar 

  50. Siegrist A. [Contribution to the knowledge of arteriosclerosis of the vessels of the eye] Beitrag zur Kenntnis der Arteriosklerose der Augengefasse (Abstract in: Zeitschr Augenheilkd 1899;2(Suppl):36–7). IXth International Congress on Ophthalmology; 1899. p. 131–9.

    Google Scholar 

  51. Drasche A. As cited by Hayreh SS, Servais GE, Virdi PS. Fundus lesions in malignant hypertension. VI. Hypertensive choroidopathy. Ophthalmology. 1986;93:1383–400. Z Ges Aerzte Wien. 1855:468.

    Google Scholar 

  52. Virchow R. Zur pathologischen Anatomie der Netzhaut und des Sehnerven. Virchows Arch. 1856;10:170–93.

    Google Scholar 

  53. Müller H. [About changes to the choroid in Bright’s disease] Ueber Veränderungen an der Chorioidea bei Morbus Brightii. Verhandl phys-med Ges Würzburg. 1857;7:293–9.

    Google Scholar 

  54. Müller H. Disease of the choroid, vitreous humour and retina in Bright’s disease, together with a peculiar form of embolus (Translated by JS Wells). R Lond Ophthalmic Hosp Rep. 1860;3:50–9.

    Google Scholar 

  55. Wagner A. Ueber Amblyopie und Amaurose bei Bright’scher Nierenkrankheit. Virchows Arch. 1857;12:218–71.

    Google Scholar 

  56. Cohen M. Significance of pathologic changes in fundus; in general arterial and kidney diseases. Trans AMA Sect Ophthalmol. 1922:60–72.

    Google Scholar 

  57. Cohen M. Chorioretinal arteriolar necrosis in malignant hypertension; report of a case. Arch Ophthalmol. 1940;23:1052–9.

    Google Scholar 

  58. Meves H. Die pathologisch-anatomischen Gefäßveränderungen des Auges bei der benignen und malignen Nephrosklerose. Albrecht von Graefes Arch Ophthalmol. 1948;148:287–317.

    CAS  PubMed  Google Scholar 

  59. Harry J, Ashton N. The pathology of hypertensive retinopathy. Trans Ophthalmol Soc U K. 1963;83:71–90.

    CAS  PubMed  Google Scholar 

  60. Friedman E, Smith TR, Kuwabara T, Beyer CK. Choroidal vascular patterns in hypertension. Arch Ophthalmol. 1964;71:842–50.

    CAS  PubMed  Google Scholar 

  61. Uyama M. Ophthalmological studies on experimental hypertension. 2. A histopathological study of the rat eyes with experimental renal hypertension. Nihon Ganka Gakkai Zasshi. 1967;71:303–19.

    CAS  PubMed  Google Scholar 

  62. Uyama M. Histopathological studies on vascular changes, especially on involvements in the choroidal vessels, in hypertensive retinopathy (author’s transl). Nihon Ganka Gakkai Zasshi. 1975;79:357–70.

    CAS  PubMed  Google Scholar 

  63. Ashton N. The eye in malignant hypertension. Trans Am Acad Ophthalmol Otolaryngol. 1972;76:17–40.

    CAS  PubMed  Google Scholar 

  64. Duke-Elder S. Textbook of ophthalmology, vol. 3. St. Louis: C.V. Mosby; 1940. p. 2387–8.

    Google Scholar 

  65. Hayreh SS. The long posterior ciliary arteries. An experimental study. Albrecht von Graefes Arch Klin Exp Ophthalmol. 1974;192:197–213.

    CAS  PubMed  Google Scholar 

  66. Hayreh SS, Baines JA. Occlusion of the posterior ciliary artery. II. Chorio-retinal lesions. Br J Ophthalmol. 1972;56:736–53.

    PubMed Central  CAS  PubMed  Google Scholar 

  67. Hayreh SS. The choriocapillaris. Albrecht von Graefes Arch Klin Exp Ophthalmol. 1974;192:165–79.

    CAS  PubMed  Google Scholar 

  68. Laties AM, Jacobowitz D. A comparative study of the autonomic innervation of the eye in monkey, cat, and rabbit. Anat Rec. 1966;156:383–95.

    CAS  PubMed  Google Scholar 

  69. Gitter KA, Houser BP, Sarin LK, Justice Jr J. Toxemia of pregnancy: an angiographic interpretation of fundus changes. Arch Ophthalmol. 1968;80:449–54.

    CAS  PubMed  Google Scholar 

  70. Kenny GS, Cerasoli JR. Color fluorescein angiography in toxemia of pregnancy. Arch Ophthalmol. 1972;87:383–8.

    CAS  PubMed  Google Scholar 

  71. Fastenberg DM, Fetkenhour CL, Choromokos E, Shoch DE. Choroidal vascular changes in toxemia of pregnancy. Am J Ophthalmol. 1980;89:362–8.

    CAS  PubMed  Google Scholar 

  72. Mabie WC, Ober RR. Fluorescein angiography in toxaemia of pregnancy. Br J Ophthalmol. 1980;64:666–71.

    PubMed Central  CAS  PubMed  Google Scholar 

  73. Saito T, Shimizu S. Fluorescence fundus angiography of cyst-like elevations associated with toxemia of pregnancy. Folia Ophthalmol Jpn. 1980;31:152–6.

    Google Scholar 

  74. Dornan KJ, Mallek DR, Wittmann BK. The sequelae of serous retinal detachment in preeclampsia. Obstet Gynecol. 1982;60:657–63.

    CAS  PubMed  Google Scholar 

  75. Hayreh SS. Acute occlusive disorders of the choroidal vasculature. Int Ophthalmol. 1983;6:139–48.

    CAS  PubMed  Google Scholar 

  76. Hayreh SS. Macular lesions secondary to choroidal vascular disorders. Int Ophthalmol. 1983;6:161–70.

    CAS  PubMed  Google Scholar 

  77. Xu W, Grunwald JE, Metelitsina TI, DuPont JC, Ying GS, Martin ER, et al. Association of risk factors for choroidal neovascularization in age-related macular degeneration with decreased foveolar choroidal circulation. Am J Ophthalmol. 2010;150:40–7.

    PubMed Central  PubMed  Google Scholar 

  78. Hayreh SS. Submacular choroidal vascular bed watershed zones and their clinical importance. Am J Ophthalmol. 2010;150:940–1.

    PubMed  Google Scholar 

  79. Hayreh SS, Zimmerman MB. Optic disc edema in non-arteritic anterior ischemic optic neuropathy. Graefes Arch Clin Exp Ophthalmol. 2007;245:1107–21.

    PubMed  Google Scholar 

  80. Tso MO, Fine BS. Electron microscopic study of human papilledema. Am J Ophthalmol. 1976;82:424–34.

    CAS  PubMed  Google Scholar 

  81. Tso MO, Hayreh SS. Optic disc edema in raised intracranial pressure. III. A pathologic study of experimental papilledema. Arch Ophthalmol. 1977;95:1448–57.

    CAS  PubMed  Google Scholar 

  82. Anderson DR. Ultrastructure of human and monkey lamina cribrosa and optic nerve head. Arch Ophthalmol. 1969;82:800–14.

    CAS  PubMed  Google Scholar 

  83. Radius RL, Gonzales M. Anatomy of the lamina cribrosa in human eyes. Arch Ophthalmol. 1981;99:2159–62.

    CAS  PubMed  Google Scholar 

  84. Sossi N, Anderson DR. Blockage of axonal transport in optic nerve induced by elevation of intraocular pressure. Effect of arterial hypertension induced by angiotensin I. Arch Ophthalmol. 1983;101:94–7.

    CAS  PubMed  Google Scholar 

  85. Dollery CT. Hypertensive retinopathy. In: Genest J, Kuchel O, Hamet P, Cantin M, editors. Hypertension: physiopathology and treatment. 2nd ed. New York: McGraw Hill; 1983. p. 723–32.

    Google Scholar 

  86. Hayreh SS. Anterior ischemic optic neuropathy. V. Optic disc edema an early sign. Arch Ophthalmol. 1981;99:1030–40.

    CAS  PubMed  Google Scholar 

  87. Hayreh SS, Zimmerman MB. Incipient nonarteritic anterior ischemic optic neuropathy. Ophthalmology. 2007;114:1763–72.

    PubMed  Google Scholar 

  88. Cove DH, Seddon M, Fletcher RF, Dukes DC. Blindness after treatment for malignant hypertension. Br Med J. 1979;2:245–6.

    PubMed Central  CAS  PubMed  Google Scholar 

  89. Wetherill JH. Blindness after treatment for malignant hypertension. Br Med J. 1979;2:550.

    PubMed Central  CAS  PubMed  Google Scholar 

  90. Pryor JS, Davies PD, Hamilton DV. Blindness and malignant hypertension. Lancet. 1979;2:803.

    CAS  PubMed  Google Scholar 

  91. Hulse JA, Taylor DS, Dillon MJ. Blindness and paraplegia in severe childhood hypertension. Lancet. 1979;2:553–6.

    CAS  PubMed  Google Scholar 

  92. Taylor D, Ramsay J, Day S, Dillon M. Infarction of the optic nerve head in children with accelerated hypertension. Br J Ophthalmol. 1981;65:153–60.

    PubMed Central  CAS  PubMed  Google Scholar 

  93. Ledingham JG, Rajagopalan B. Cerebral complications in the treatment of accelerated hypertension. Q J Med. 1979;48:25–41.

    CAS  PubMed  Google Scholar 

  94. Strandgaard S, Olesen J, Skinhoj E, Lassen NA. Autoregulation of brain circulation in severe arterial hypertension. Br Med J. 1973;1:507–10.

    PubMed Central  CAS  PubMed  Google Scholar 

  95. Fitch W, MacKenzie ET, Harper AM. Effects of decreasing arterial blood pressure on cerebral blood flow in the baboon. Influence of the sympathetic nervous system. Circ Res. 1975;37:550–7.

    CAS  PubMed  Google Scholar 

  96. Strandgaard S, MacKenzie ET, Jones JV, Harper AM. Studies on the cerebral circulation of the baboon in acutely induced hypertension. Stroke. 1976;7:287–90.

    CAS  PubMed  Google Scholar 

  97. Edvinsson L, Owman C, Siesjo B. Physiological role of cerebrovascular sympathetic nerves in the autoregulation of cerebral blood flow. Brain Res. 1976;117:519–23.

    CAS  PubMed  Google Scholar 

  98. Bill A, Linder J. Sympathetic control of cerebral blood flow in acute arterial hypertension. Acta Physiol Scand. 1976;96:114–21.

    CAS  PubMed  Google Scholar 

  99. MacKenzie ET, McGeorge AP, Graham DI, Fitch W, Edvinsson L, Harper AM. Breakthrough of cerebral autoregulation and the sympathetic nervous system. Acta Neurol Scand Suppl. 1977;64:48–9.

    CAS  PubMed  Google Scholar 

  100. Hayreh SS. Optic disc edema in raised intracranial pressure. V. Pathogenesis. Arch Ophthalmol. 1977;95:1553–65.

    CAS  PubMed  Google Scholar 

  101. Gowers WR. The state of the arteries in Bright’s disease. Br Med J. 1876;2:743–5.

    PubMed Central  CAS  PubMed  Google Scholar 

  102. Volhard F, Fahr T. Die Brightsche Nierenkrankheit: Klinik, Pathologie und Atlas. Berlin: Springer; 1914.

    Google Scholar 

  103. Volhard F. The pathogenesis of albuminuric retinitis. Zentralbl Gesamte Ophthalmol. 1929;20:627–8.

    Google Scholar 

  104. Volhard F. Medizinischer Teil. Zentralbl Gesamte Ophthalmol. 1921;5:470–81.

    Google Scholar 

  105. Stokoe NL, Turner RW. Normal retinal vascular pattern. Arteriovenous ratio as a measure of arterial calibre. Br J Ophthalmol. 1966;50:21–40.

    PubMed Central  CAS  PubMed  Google Scholar 

  106. Nicholls JV, Turnbull W, Evelyn KA. The calibre of the retinal arterioles in normal and hypertensive patients. Trans Can Ophthalmol Soc. 1956;7:37–45.

    Google Scholar 

  107. Cogan DG. Ophthalmic manifestations of systemic vascular disease (Major problems in internal medicine, v. 3). Philadelphia: Saunders; 1974. p. 74–8.

    Google Scholar 

  108. Moore RF. The retinitis of arteriosclerosis, and its relation to renal retinitis and to cerebral vascular disease. Q J Med. 1917;os-10:29–77.

    Google Scholar 

  109. Pickering GW. High blood pressure. 2nd ed. London: Churchill; 1968. p. 342–3.

    Google Scholar 

  110. Garner A. Experimental hypertensive retinopathy [PhD Thesis]. University of London; 1972.

    Google Scholar 

  111. Byrom FB. The nature of malignancy in hypertensive disease. Evidence from the retina of the rat. Lancet. 1963;1(7280):516–20.

    CAS  PubMed  Google Scholar 

  112. Bellhorn RW. Pathophysiology of retinal vessels in experimentally hypertensive rats [Masters of Science Thesis]. New York University; 1966.

    Google Scholar 

  113. Reed RK, Sapirstein LA, Southard FD, Ogden E. Effects of nembutal and yohimbine on chronic renal hypertension in the rat. Am J Physiol. 1944;141:707–12.

    CAS  Google Scholar 

  114. Green DM, Saunders FJ, Wahlgren N, Craig RL. Self-sustaining, post-DCA hypertensive cardiovascular disease. Am J Physiol. 1952;170:94–106.

    CAS  PubMed  Google Scholar 

  115. Carl T. Ein Beitrag zur pathologischen Anatomie des Auges bei Nierenleiden. Wiesbaden: Bergmann; 1997.

    Google Scholar 

  116. Buechner F. The role of the heart muscle in angina pectoris. Beitr Pathol Anat. 1932;89:644–67.

    Google Scholar 

  117. Leishman R. The eye in general vascular disease: hypertension and arteriosclerosis. Br J Ophthalmol. 1957;41:641–701.

    PubMed Central  CAS  PubMed  Google Scholar 

  118. Hill D. Fluorescence angiography. Trans Ophthalmol Soc U K. 1969;88:187–9.

    CAS  PubMed  Google Scholar 

  119. Abt K, Bruckner R. Netzhautgefassspasmen bei artifiziell hypertonischen Ratten. Ophthalmologica. 1950;119:17–43.

    CAS  PubMed  Google Scholar 

  120. Byrom FB. The caliber of the retinal arteries in hypertension. Am Heart J. 1963;66:727–30.

    CAS  PubMed  Google Scholar 

  121. Goldby FS, Beilin LJ. The microcirculation in malignant hypertension. In: Rorive G, Van Cauwenberge H, editors. The arterial hypertensive disease: a symposium. New York: Masson; 1976. p. 51–62.

    Google Scholar 

  122. Byrom FB. The hypertensive vascular crisis; an experimental study. New York: Grune & Stratton; 1969.

    Google Scholar 

  123. Kontos HA, Wei EP, Dietrich WD, Navari RM, Povlishock JT, Ghatak NR, et al. Mechanism of cerebral arteriolar abnormalities after acute hypertension. Am J Physiol. 1981;240:H511–27.

    CAS  PubMed  Google Scholar 

  124. Byrom FB. The third Volhard lecture. Tension and the artery: the experimental elucidation of pseudo-uraemia and malignant nephrosclerosis. Clin Sci Mol Med Suppl. 1976;3:35–115.

    CAS  PubMed  Google Scholar 

  125. Hodge JV, Dollery CT. Retinal soft exudates. A clinical study by colour and fluorescence photography. Q J Med. 1964;33:117–31.

    CAS  PubMed  Google Scholar 

  126. Giacomelli F, Juechter KB, Wiener J. The cellular pathology of experimental hypertension. VI. Alterations in retinal vasculature. Am J Pathol. 1972;68:81–96.

    PubMed Central  CAS  PubMed  Google Scholar 

  127. Dutton JJ, Krupin T, Waltman SR, Koloms BA, Becker B. Fluorophotometry and the blood-ocular barrier in experimental systemic hypertension. Arch Ophthalmol. 1980;98:731–3.

    CAS  PubMed  Google Scholar 

  128. Krupin T, Waltman SR, Szewczyk P, Koloms B, Farber M, Silverstein B, et al. Fluorometric studies on the blood-retinal barrier in experimental animals. Arch Ophthalmol. 1982;100:631–4.

    CAS  PubMed  Google Scholar 

  129. Jampol LM, White S, Cunha-Vaz J. Vitreous fluorophotometry in patients with hypertension. Arch Ophthalmol. 1983;101:888–90.

    CAS  PubMed  Google Scholar 

  130. Scarpelli PT, Brancato R, Menchini U, Santoro P, Lamanna S. The close interrelationship between increased vascular retinal permeability and blood pressure level. Evidence from retinal fluorangiography. Ophthalmologica. 1977;175:309–20.

    CAS  PubMed  Google Scholar 

  131. Yoshimoto H, Murata M. Ultrastructural aspects of hyperpermeability of the retinal blood vessels of spontaneous hypertensive rats. Jpn J Ophthalmol. 1976;20:497–513.

    Google Scholar 

  132. Okabayashi T, Nakamura M, Sumiyoshi A, Oka Y, Fukiyama K. Perinephritis hypertension in monkeys. I. An increase of plasma renin activity associated with increased permeability of retinal vessels and angionecrosis. Jpn Heart J. 1976;17:61–72.

    CAS  PubMed  Google Scholar 

  133. Henkind P. Microcirculation of the peripapillary retina. Trans Am Acad Ophthalmol Otolaryngol. 1969;73:890–7.

    CAS  PubMed  Google Scholar 

  134. Goldby FS, Beilin LJ. The evolution and healing of arteriolar damage in renal-clip hypertension in the rat: an electron microscope study. Clin Sci. 1973;44:5P passim.

    Google Scholar 

  135. Dollery CT, Hodge JV. Hypertensive retinopathy studied with fluorescein. Trans Ophthalmol Soc U K. 1963;83:115–32.

    CAS  PubMed  Google Scholar 

  136. Dollery CT. The retinal circulation in hypertension and diabetes. Sci Basis Med Annu Rev. 1969:44–59.

    Google Scholar 

  137. Dollery CT. Microcirculatory changes and the cotton-wool spot. Proc R Soc Med. 1969;62:1267–9.

    PubMed Central  CAS  PubMed  Google Scholar 

  138. Friedenwald JS. A new approach to some problems of retinal vascular disease. Am J Ophthalmol. 1949;32:487–98.

    CAS  PubMed  Google Scholar 

  139. Ashton N, Harry J. The pathology of cotton wool spots and cytoid bodies in hypertensive retinopathy and other diseases. Trans Ophthalmol Soc U K. 1963;83:91–114.

    CAS  PubMed  Google Scholar 

  140. McLeod D, Marshall J, Kohner EM, Bird AC. The role of axoplasmic transport in the pathogenesis of retinal cotton-wool spots. Br J Ophthalmol. 1977;61:177–91.

    PubMed Central  CAS  PubMed  Google Scholar 

  141. Henkind P. Symposium on glaucoma: joint meeting with the National Society for the Prevention of Blindness. New observations on the radial peripapillary capillaries. Invest Ophthalmol. 1967;6:103–8.

    CAS  PubMed  Google Scholar 

  142. Dollery CT, Henkind P, Paterson JW, Ramalho PS, Hill DW. I. Ophthalmoscopic and circulatory changes in focal retinal ischaemia. Br J Ophthalmol. 1966;50:285–324.

    PubMed Central  CAS  PubMed  Google Scholar 

  143. Dollery CT, Hodge JV, Engel M. Studies of the retinal circulation with fluorescein. Br Med J. 1962;2:1210–5.

    PubMed Central  CAS  PubMed  Google Scholar 

  144. Gass JD. A fluorescein angiographic study of macular dysfunction secondary to retinal vascular disease. 3. Hypertensive retinopathy. Arch Ophthalmol. 1968;80:569–82.

    CAS  PubMed  Google Scholar 

  145. Heymann FM. Ueber Amaurose bei Brightischer Krankheit, und Fettdegeneration der Netzhaut. Archiv für Ophthalmologie. 1856;2:137–50.

    Google Scholar 

  146. Müller H. Anatomische Beiträge zur Ophthalmologie. Archiv für Ophthalmologie. 1858;4:363–88.

    Google Scholar 

  147. Leber T. Die Krankheiten der Netzhaut. In: Graefe-Saemisch Handbuch der gesamten Augenheilkunde, 7/2. 2nd ed. Leipzig: Engelman; 1915. p. 840.

    Google Scholar 

  148. Koyanagi Y. The importance of the vascular junction for the development of thrombosis of the retinal central vein. Klin Monatsbl Augenheilkd. 1928;81:219–31.

    Google Scholar 

  149. Wolter JR. Pathology of a cotton-wool spot. Am J Ophthalmol. 1959;48:473–85.

    CAS  PubMed  Google Scholar 

  150. Shakib M, Ashton II N. Ultrastructural changes in focal retinal ischaemia. Br J Ophthalmol. 1966;50:325–84.

    PubMed Central  CAS  PubMed  Google Scholar 

  151. Inomata H, Ikui H, Kimura K. Pathogenesis of cotton-wool spots. 1. Fine structure of cytoid bodies. Nihon Ganka Gakkai Zasshi. 1967;71:1352–64.

    CAS  PubMed  Google Scholar 

  152. Ashton N. Pathophysiology of retinal cotton-wool spots. Br Med Bull. 1970;26:143–50.

    CAS  PubMed  Google Scholar 

  153. Gay AJ, Goldor H, Smith M. Chorioretinal vascular occlusions with latex spheres. Invest Ophthalmol. 1964;3:647–56.

    CAS  PubMed  Google Scholar 

  154. Ashton N, Henkind P. Experimental occlusion of retinal arterioles: using graded glass ballotini. Br J Ophthalmol. 1965;49:225–34.

    PubMed Central  CAS  PubMed  Google Scholar 

  155. Ashton N. Diabetic retinopathy: a new approach. Lancet. 1959;2:625–30.

    CAS  PubMed  Google Scholar 

  156. McLeod D. Why cotton wool spots should not be regarded as retinal nerve fibre layer infarcts. Br J Ophthalmol. 2005;89:229–37.

    PubMed Central  CAS  PubMed  Google Scholar 

  157. Wagener HP, Clay GE, Gipner JF. Classification of retinal lesions in the presence of vascular hypertension: report submitted to the American Ophthalmological Society by the committee on Classification of Hypertensive Disease of the Retina. Trans Am Ophthalmol Soc. 1947;45:57–73.

    PubMed Central  CAS  PubMed  Google Scholar 

  158. Bresnick GH, Engerman R, Davis MD, de Venecia G, Myers FL. Patterns of ischemia in diabetic retinopathy. Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol. 1976;81(4 Pt 1):OP694–709.

    CAS  PubMed  Google Scholar 

  159. Ballantyne AJ, Michaelson IC. Textbook of the fundus of the eye. Baltimore: Williams and Wilkins; 1970. p. 179.

    Google Scholar 

  160. Duke-Elder S, Dobree JH. System of ophthalmology. In: Duke-Elder S, editor. Diseases of the retina, vol 10. London: Kimpton; 1967. p. 141, 330–332, 340.

    Google Scholar 

  161. Wise GN, Dollery CT, Henkind P. The retinal circulation. New York: Harper & Row; 1971. p. 331.

    Google Scholar 

  162. Yanoff M. Ocular pathology of diabetes mellitus. Am J Ophthalmol. 1969;67:21–38.

    CAS  PubMed  Google Scholar 

  163. Houston WR, Wise GN. Circinate retinopathy. I. AMA Arch Ophthalmol. 1957;58:777–82.

    CAS  PubMed  Google Scholar 

  164. Bloodworth Jr JM. Diabetic retinopathy. Diabetes. 1962;11:1–22.

    PubMed  Google Scholar 

  165. Meyer JS, Waltz AG, Gotoh F. Pathogenesis of cerebral vasospasm in hypertensive encephalopathy. I. Effect of acute increases in intraluminal blood pressure on pial blood flow. Neurol Clin Neurophysiol. 1960;10:735–44.

    Google Scholar 

  166. Moore RF. Medical ophthalmology. 2nd ed. London: Churchill; 1925. p. 189–90.

    Google Scholar 

  167. Friedenwald JS. Pathogenesis of albuminuric retinitis. Contributions to the Medical Sciences in Honor of Dr. Emanuel Libman (Libman Anniversary Volumes), vol. 2. New York: The International Press; 1932. p. 453–8.

    Google Scholar 

  168. Hallum AV. Changes in retinal arterioles associated with the hypertensions of pregnancy. Arch Ophthal. 1947;37:472–90.

    CAS  PubMed  Google Scholar 

  169. Oliver M, Uchenik D. Bilateral exudative retinal detachment in eclampsia without hypertensive retinopathy. Am J Ophthalmol. 1980;90:792–6.

    CAS  PubMed  Google Scholar 

  170. McEvoy M, Runciman J, Edmonds DK, Kerin JF. Bilateral retinal detachment in association with preeclampsia. Aust N Z J Obstet Gynaecol. 1981;21:246–7.

    CAS  PubMed  Google Scholar 

  171. Keith NM, Wagener HP, Barker NW. Some different types of essential hypertension: their course and prognosis. Am J Med Sci. 1939;197:332–43.

    Google Scholar 

  172. Scheie HG. Evaluation of ophthalmoscopic changes of hypertension and arteriolar sclerosis. AMA Arch Ophthalmol. 1953;49:117–38.

    CAS  PubMed  Google Scholar 

  173. McGregor E, Isles CG, Jay JL, Lever AF, Murray GD. Retinal changes in malignant hypertension. Br Med J (Clin Res Ed). 1986;292:233–4.

    CAS  Google Scholar 

  174. Michaelson IC, Eliakim M, Avshalom A, Medalie JH, Ivry M, Neumann E. An approach to the investigation of the vascular changes in the fundus of the eye in hypertension and arteriosclerosis. In: Weigelin E, editor. Acta XX Concilium Ophthalmologicum, Germania, Part l. Amsterdam: Excerpta Medica Foundation; 1966. p. 207–20.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Hayreh, S.S. (2015). Arterial Hypertension and the Eye. In: Ocular Vascular Occlusive Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-12781-1_23

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-12781-1_23

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-12780-4

  • Online ISBN: 978-3-319-12781-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics