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Molecular Mechanisms Underpinning the Development of Obesity pp 179–194Cite as

Obesity and Type 2 Diabetes

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Abstract

Prevalence of type 2 diabetes and obesity have increased at an alarming rate worldwide not only in adults but also in children and adolescents. Both type 2 diabetes and obesity are multifactorial diseases associated with multiple co-morbidities. Its etiology involves a complex interplay between environment, genetic, and epigenetic factors. In this chapter we will discuss especially the relationship between obesity and diabetes and the potential mechanisms involved. The major cause of death in diabetes is cardiovascular disease and the most devastating and financially costly diabetes microvascular complication is end-stage renal disease requiring renal replacement therapy and renal transplantation. Therefore, the chapter will concentrate on mortality, coronary artery disease, and nephropathy in type 2 diabetes within the context of obesity.

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Authors and Affiliations

  1. Department of Medicine, Weill Cornell Medical College—Qatar, Qatar Foundation—Education City, PO Box 24144, Doha, Qatar

    Shahrad Taheri

  2. Department of Genetic Medicine and Department of Medicine, Weill Cornell Medical College—Qatar, Qatar Foundation—Education City, PO Box 24144, Doha, Qatar

    Charbel Abi Khalil

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  2. Shahrad Taheri
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Correspondence to Shahrad Taheri .

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  1. Cntr for Neurosciences and Cell Biology University of Coimbra, Coimbra, Portugal

    Clévio Nóbrega

  2. Nutrition and Gastroenterology Department, Armand-Trousseau Hospital, Valencia, Spain

    Raquel Rodriguez-López

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Abi Khalil, C., Taheri, S. (2014). Obesity and Type 2 Diabetes. In: Nóbrega, C., Rodriguez-López, R. (eds) Molecular Mechanisms Underpinning the Development of Obesity. Springer, Cham. https://doi.org/10.1007/978-3-319-12766-8_12

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