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Obesity Study: Animal Models

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Molecular Mechanisms Underpinning the Development of Obesity

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Abstract

Obesity is becoming a worldwide problem, as it is associated with serious comorbidities, including a high incidence of type II diabetes, cardiovascular disease and many forms of cancer. Obesity is defined as increased adipose mass resulting from chronic excess of energy intake over energy expenditure. Energy homeostasis including food intake and energy consumption has been demonstrated to be regulated predominantly by orexigenic and anorexigenic systems in the hypothalamus. The blood-born hormones, such as leptin, insulin and ghrelin, modulate activities of the orexigenic and anorexigenic neuropeptide-containing neurons in the hypothalamus. In addition, epidemiological studies have demonstrated that the incidence of depression and cognitive impairment is high in obese subjects compared to normal body weight subjects. Therefore, obese animal models that are pathophysiologically relevant to human obesity are very useful for understanding the mechanisms underlying the development of obesity and obesity-associated syndromes. This chapter shows representative animal obese models that are used to analyze pathophysiological properties of obesity.

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Authors and Affiliations

  1. Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, 890-8520, Kagoshima, Japan

    Goro Katsuura, Namiko Kawamura, Miyuki Nishida, Haruka Amitani, Akihiro Asakawa & Akio Inui

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  1. Goro Katsuura
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  2. Namiko Kawamura
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Correspondence to Akio Inui .

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  1. Cntr for Neurosciences and Cell Biology University of Coimbra, Coimbra, Portugal

    Clévio Nóbrega

  2. Nutrition and Gastroenterology Department, Armand-Trousseau Hospital, Valencia, Spain

    Raquel Rodriguez-López

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Katsuura, G., Kawamura, N., Nishida, M., Amitani, H., Asakawa, A., Inui, A. (2014). Obesity Study: Animal Models. In: Nóbrega, C., Rodriguez-López, R. (eds) Molecular Mechanisms Underpinning the Development of Obesity. Springer, Cham. https://doi.org/10.1007/978-3-319-12766-8_10

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