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How Nanoparticles Can Solve Resistance and Limitation in PDT Efficiency

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Resistance to Photodynamic Therapy in Cancer

Part of the book series: Resistance to Targeted Anti-Cancer Therapeutics ((RTACT,volume 5))

Abstract

PDT efficiency photosensitizers can be improved by different ways: development of targeted photosensitizers that also present rapid clearance from normal tissues, photosensitizers that own better photophysical properties (such as absorption in the red to use light that can better penetrate tissue, limited photobleaching), photosensitizers whose pharmacokinetics matched to the application, improve light equipments and the selective delivery of the activating light. In this chapter, our aim is to address how nanoparticles could be one of the solutions to improve PDT efficiency and to bypass the phenomena of resistance and limitations to PDT. We will describe how the use of nanoparticles can be positive for activation system, biodistribution properties, tumor selectivity by selecting judicious molecular and cellular targets.

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Abbreviations

5-ALA:

5-aminolevulinic acid

AIPc:

Aluminium pthalocyanine

AuNP:

Gold nanoparticle

BDSA:

9,10-bis (4′-(4″-aminostyryl)styryl)anthracene

DOTA:

1,4,7,10-tetraazacycloDOdecane-Tetraacetic Acid

DPBF:

1,3-DiPhenilisoBenzoFuran

DTPA:

Diethylene Triamine Pentaacetic acid

EGF:

Epidermal Growth Factor

EGFR:

Epidermal Growth Factor

FDA:

Food Drug Administration

FITC:

Fluorescein IsoThioCyanate

FRET:

Förster Resonance Energy Transfer

HPPH:

2-(1-Hexyloxyethyl)-2-devinyl PyroPheophorbide-a

Hy:

Hypericin

ICG:

IndoCyanine Green

LDL:

Low Density Lipoprotein

MB:

Methylene Blue

MRI:

Magnetic Resonance Imaging

mTHPC:

m-TetraHydroxyPhenylChlorin

MTT:

bromure de 3-(4,5-diMethylThiazol-2-yl)-2,5-diphenyl Tetrazolium

NRP-1:

NeuRoPilin-1

PAA:

PolyAcrylAmide

Pc4:

Phtalocyanine

PDT:

Photo Dynamic Therapy

PEBBLE:

Photonic Explorer for Bianalysis with Biologically Localized Embedding

PEG:

PolyEthylene Glycol

PEGDMA:

Poly(Ethylene Glycol) Di MethAcrylate

PEG-PCL:

Poly (Ethylene Glycol)-block-PyreoPheophorbide a

PUNPS:

Photon Up-Converting Nanoparticles

RGD:

ArginylGlycylAspartic acid

ROS:

Reactive Oxygen Species

SLN:

Solid Lipid Nanoparticle

SLPDT:

Self-Lighting PDT

TMPyP:

5,10,15,20-Tetrakis(1-Methyl 4-Pyridino)Porphyrin tetra(p-toluensulfonate)

TPA:

Two Photon Absorption

UCNP:

UpConversion NanoPlateform

VEGF:

Vascular Endothelial Growth Factor

VTP:

Vascular Targeted Photodynamic therapy

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Acknowledgments

This work was supported by the research fonds of the French Ligue Nationale contre le cancer.

Author information

Authors and Affiliations

  1. CRAN UMR 7039, CNRS, Vandœuvre-lès-Nancy, France

    Magali Toussaint, Dr. Muriel Barberi-Heyob & Sophie Pinel

  2. CRAN UMR 7039, Université de Lorraine, Vandœuvre-lès-Nancy, France

    Magali Toussaint, Dr. Muriel Barberi-Heyob & Sophie Pinel

  3. GDR 3049 “Médicaments Photoactivables—Photochimiothérapie (PHOTOMED)”, Nancy, France

    Dr. Muriel Barberi-Heyob & Céline Frochot

  4. LRGP UMR 7274, CNRS, Nancy, France

    Céline Frochot

  5. LRGP UMR 7274, Université de Lorraine, Nancy, France

    Céline Frochot

Authors
  1. Magali Toussaint
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  2. Dr. Muriel Barberi-Heyob
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  3. Sophie Pinel
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  4. Céline Frochot
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Corresponding author

Correspondence to Muriel Barberi-Heyob .

Editor information

Editors and Affiliations

  1. Medical and Biological Sciences, University of Udine, Udine, Italy

    Valentina Rapozzi

  2. Prof. Ghiretti, Universita Padova Ist. Biologia Animale, Padova, Italy

    Giulio Jori

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Toussaint, M., Barberi-Heyob, M., Pinel, S., Frochot, C. (2015). How Nanoparticles Can Solve Resistance and Limitation in PDT Efficiency. In: Rapozzi, V., Jori, G. (eds) Resistance to Photodynamic Therapy in Cancer. Resistance to Targeted Anti-Cancer Therapeutics, vol 5. Springer, Cham. https://doi.org/10.1007/978-3-319-12730-9_9

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