Skip to main content
SpringerLink
Log in

Synthetic Corticosteroids

  • Chapter
  • First Online:
Neuroimaging Pharmacopoeia

  • 1298 Accesses

Abstract

Synthetic corticosteroids are exogenous analogues of naturally occurring glucocorticoids and mineral corticoids produced by the adrenal glands. In particular, synthetic glucocorticoids serve an important role in anti-inflammatory and immunosuppressive therapies. Indeed, they are widely used to treat inflammatory conditions such as rheumatoid arthritis, lupus, inflammatory bowel disease, multiple sclerosis, psoriasis, asthma, and eczema. Glucocorticoids are also used in neuro-oncology in the treatment of CNS lymphoma and leukemia, as well as treatment of tumor and radiation-associated edema. In addition, they are included as part of immunosuppressive regimes following organ transplant. Further discussion in this chapter is focused on the effects of glucocorticoids.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Suggested Reading

  • Coutinho AE, Chapman KE. The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights. Mol Cell Endocrinol. 2011;335(1):2–13.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Fassett DR, Schmidt MH. Spinal epidural lipomatosis: a review of its causes and recommendations for treatment. Neurosurg Focus. 2004;16(4):E11.

    PubMed  Google Scholar 

  • Klein NC, Go CH, Cunha BA. Infections associated with steroid use. Infect Dis Clin North Am. 2001;15(2):423–32, viii.

    Article  CAS  PubMed  Google Scholar 

  • Lukert BP, Raisz LG. Glucocorticoid-induced osteoporosis: pathogenesis and management. Ann Intern Med. 1990;112(5):352–64.

    Article  CAS  PubMed  Google Scholar 

  • Nishimura J, Ikuyama S. Glucocorticoid-induced osteoporosis: pathogenesis and management. J Bone Miner Metab. 2000;18(6):350–2.

    Article  CAS  PubMed  Google Scholar 

  • Pujols L, Alobid I, Benítez P, Martínez-Antón A, Roca-Ferrer J, Fokkens WJ, Mullol J, Picado C. Regulation of glucocorticoid receptor in nasal polyps by systemic and intranasal glucocorticoids. Allergy. 2008;63(10):1377–86.

    Google Scholar 

  • Rhen T, Cidlowski JA. Antiinflammatory action of glucocorticoids–new mechanisms for old drugs. N Engl J Med. 2005;353(16):1711–23.

    Article  CAS  PubMed  Google Scholar 

  • Spies CM, Strehl C, van der Goes MC, Bijlsma JW, Buttgereit F. Glucocorticoids. Best Pract Res Clin Rheumatol. 2011;25(6):891–900.

    Article  CAS  PubMed  Google Scholar 

  • Venekamp RP, Thompson MJ, Hayward G, Heneghan CJ, Del Mar CB, Perera R, Glasziou PP, Rovers MM. Systemic corticosteroids for acute sinusitis. Cochrane Database Syst Rev. 2011;7(12):CD008115.

    Google Scholar 

  • Zanardi VA, Magna LA, Costallat LT. Cerebral atrophy related to corticotherapy in systemic lupus erythematosus (SLE). Clin Rheumatol. 2001;20(4):245–50.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Diagnostic Radiology, MD Anderson Cancer Center, Houston, TX, USA

    Jason M. Johnson MD

  2. Department of Radiology, University of California, San Francisco, CA, USA

    Yi Li MD

  3. Department of Radiology, University of Chicago, Pritzker Medical School, Chicago, IL, USA

    Daniel Thomas Ginat MD, MS

Authors
  1. Jason M. Johnson MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yi Li MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Daniel Thomas Ginat MD, MS
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Daniel Thomas Ginat MD, MS .

Editor information

Editors and Affiliations

  1. Department of Radiology, University of Chicago, Pritzker Medical School, Chicago, Illinois, USA

    Daniel Thomas Ginat

  2. Department of Radiology, Lahey Clinic, Burlington, Massachusetts, USA

    Juan E. Small

  3. Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA

    Pamela Whitney Schaefer

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Johnson, J.M., Li, Y., Ginat, D.T. (2015). Synthetic Corticosteroids. In: Ginat, D., Small, J., Schaefer, P. (eds) Neuroimaging Pharmacopoeia. Springer, Cham. https://doi.org/10.1007/978-3-319-12715-6_46

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-12715-6_46

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-12714-9

  • Online ISBN: 978-3-319-12715-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation