Abstract
Aspirin alone is indicated in the setting of the primary prevention of coronary heart disease in individuals who have multiple coronary risk factors. It is also recommended for the secondary prevention of ischemic stroke, patients with symptomatic peripheral arterial disease, and the long-term secondary prevention of myocardial infarction. Low-dose aspirin (81 mg) is typically prescribed in the setting of primary prevention and in the long-term after a patient suffers a myocardial infarction, while high-dose aspirin (325 mg) is typically prescribed in the acute setting post-myocardial infarction and for the long-term secondary prevention of ischemic stroke. Low-dose aspirin is typically combined with oral anticoagulants such as Coumadin in the primary prevention of embolic stroke in patients with atrial fibrillation.
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Awad OG, Lee JH, Fasano MB, Graham SM. Sinonasal outcomes after endoscopic sinus surgery in asthmatic patients with nasal polyps: a difference between aspirin-tolerant and aspirin-induced asthma? Laryngoscope. 2008;118(7):1282–6.
Bhatt DL, Fox KAA, Hacke W, Berger PB, Black HR, Boden WE, Cacoub P, Cohen EA, Creager MA, Easton JD, Flather MD, Haffner SM, Hamm CW, Hankey GJ, Johnston SC, Mak K-H, Mas J-L, Montalescot G, Pearson TA, Steg PG, Steinhubl SR, Weber MA, Brennan DM, Fabry-Ribaudo L, Booth J, Topol EJ, for the CHARISMA Investigators. Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med. 2006;354:1706–17.
Kim JE, Kountakis SE. The prevalence of Samter’s triad in patients undergoing functional endoscopic sinus surgery. Ear Nose Throat J. 2007;86(7):396–9.
Mehta SR, Yusuf S, Peters RJ, Bertrand ME, Lewis BS, Natarajan MK, Malmberg K, Rupprecht H, Zhao F, Chrolavicius S, Copland I, Fox KA, Clopidogrel in Unstable angina to prevent Recurrent Events trial (CURE) Investigators. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet. 2001;358(9281):527–33.
Ozdoba C, Pfenninger J, Schroth G. Initial and follow-up MRI in a case of early diagnosed Reye’s syndrome. Neuroradiology. 1997;39(7):495–8.
Parizel PM, Makkat S, Van Miert E, Van Goethem JW, van den Hauwe L, De Schepper AM. Intracranial hemorrhage: principles of CT and MRI interpretation. Eur Radiol. 2001;11(9):1770–83.
Pfleger MJ, Hardee EP, Contant Jr CF, Hayman LA. Sensitivity and specificity of fluid-blood levels for coagulopathy in acute intracerebral hematomas. AJNR Am J Neuroradiol. 1994;15(2):217–23.
Sharis PJ, Cannon CP, Loscalzo J. The antiplatelet effects of ticlopidine and clopidogrel. Ann Intern Med. 1998;129(5):394–405.
Shen J, Peterson M, Mafee M, Nguyen QT. Aural polyps in Samter’s triad: case report and literature review. Otol Neurotol. 2012;33(5):774–8.
Singh P, Goraya JS, Gupta K, Saggar K, Ahluwalia A. Magnetic resonance imaging findings in Reye syndrome: case report and review of the literature. J Child Neurol. 2011;26(8):1009–14.
The ACTIVE Investigators. Effect of clopidogrel added to aspirin in patients with atrial fibrillation. N Engl J Med. 2009;360:2066–78.
Weisberg LA.Significance of the fluid-blood interface in intracranial hematomas in anticoagulated patients. Comput Radiol. 1987;11(4):175–9
Zeitz HJ. Bronchial asthma, nasal polyps, and aspirin sensitivity: Samter’s syndrome. Clin Chest Med. 1988;9(4):567–76.
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Galper, M., Ginat, D.T., Small, J.E. (2015). Aspirin and Plavix/Clopidogrel. In: Ginat, D., Small, J., Schaefer, P. (eds) Neuroimaging Pharmacopoeia. Springer, Cham. https://doi.org/10.1007/978-3-319-12715-6_31
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DOI: https://doi.org/10.1007/978-3-319-12715-6_31
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