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Vigabatrin (Sabril)

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Abstract

Vigabatrin can serve as adjunctive therapy for adult patients with refractory complex partial seizures who have responded inadequately to several alternative treatments and as monotherapy for pediatric patients aged 1 month to 2 years with infantile spasms.

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Suggested Reading

  • Ben-Menachem E. Mechanism of action of vigabatrin: correcting misperceptions. Acta Neurol Scand Suppl. 2011;192:5–15.

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  • Dracopoulos A, Widjaja E, Raybaud C, Westall CA, Snead 3rd OC. Vigabatrin-associated reversible MRI signal changes in patients with infantile spasms. Epilepsia. 2010;51(7):1297–304.

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  • Pearl PL, Vezina LG, Saneto RP, McCarter R, Molloy-Wells E, Heffron A, Trzcinski S, McClintock WM, Conry JA, Elling NJ, Goodkin HP, de Menezes MS, Ferri R, Gilles E, Kadom N, Gaillard WD. Cerebral MRI abnormalities associated with vigabatrin therapy. Epilepsia. 2009;50(2):184–94.

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  • Thapa M, Khanna PC. Vigabatrin-associated diffusion MRI abnormalities in tuberous sclerosis. Pediatr Radiol. 2010;40 Suppl 1:S153.

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  • Thelle T, Gammelgaard L, Hansen JK, Østergaard JR. Reversible magnetic resonance imaging and spectroscopy abnormalities in the course of vigabatrin treatment for West syndrome. Eur J Paediatr Neurol. 2011;15(3):260–4.

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Authors and Affiliations

  1. Department of Radiology, University of Chicago, Pritzker Medical School, Chicago, IL, USA

    Daniel Thomas Ginat MD, MS

Authors
  1. Daniel Thomas Ginat MD, MS
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Correspondence to Daniel Thomas Ginat MD, MS .

Editor information

Editors and Affiliations

  1. Department of Radiology, University of Chicago, Pritzker Medical School, Chicago, Illinois, USA

    Daniel Thomas Ginat

  2. Department of Radiology, Lahey Clinic, Burlington, Massachusetts, USA

    Juan E. Small

  3. Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA

    Pamela Whitney Schaefer

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© 2015 Springer International Publishing Switzerland

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Ginat, D.T. (2015). Vigabatrin (Sabril). In: Ginat, D., Small, J., Schaefer, P. (eds) Neuroimaging Pharmacopoeia. Springer, Cham. https://doi.org/10.1007/978-3-319-12715-6_29

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  • DOI: https://doi.org/10.1007/978-3-319-12715-6_29

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-12714-9

  • Online ISBN: 978-3-319-12715-6

  • eBook Packages: MedicineMedicine (R0)

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