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L-Asparaginase (Elspar/Erwinase)

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Neuroimaging Pharmacopoeia

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Abstract

Antineoplastic therapy, mainly for acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma in adult and pediatric patients.

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Suggested Reading

  • Athale UH, Chan AK. Thromboembolic complications in pediatric hematologic malignancies. Semin Thromb Hemost. 2007;33:416–26.

    Article  PubMed  Google Scholar 

  • Caruso V, Iacoviello L, Di Castelnuovo A, Storti S, Mariani G, de Gaetano G, Donati MB. Thrombotic complications in childhood acute lymphoblastic leukemia: a meta-analysis of 17 prospective studies comprising 1752 pediatric patients. Blood. 2006;108(7):2216–22.

    Article  CAS  PubMed  Google Scholar 

  • Diamini N, Billinghurst L, Kirkham J. Cerebral venous sinus thrombosis. Neurosurg Clin N Am. 2010;21:511–27.

    Article  Google Scholar 

  • Grace RF, Dahlberg SE, Neuberg D, Sallan SE, Connors JM, Neufeld EJ, et al. The frequency and management of asparaginase-related thrombosis in paediatric and adult patients with acute lymphoblastic leukaemia treated on Dana-Farber Cancer Institute consortium protocols. Br J Haematol. 2011;152:452–9.

    Article  PubMed  Google Scholar 

  • Jaillard AS, Hommel M, Mallaret M. Venous sinus thrombosis associated with androgens in a healthy young man. Stroke. 1994;25(1):212–3.

    Article  CAS  PubMed  Google Scholar 

  • Kieslich M, Porto L, Lanfermann H, et al. Cerebrovascular complications of l-asparaginase in the therapy of acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 2003;25(6):484–7.

    Article  PubMed  Google Scholar 

  • Masjuan J, Pardo J, Callejo JM, Andrés MT, Alvarez-Cermeño JC. Tamoxifen: a new risk factor for cerebral sinus thrombosis. Neurology. 2004;62(2):334–5.

    Article  CAS  PubMed  Google Scholar 

  • Papet C, Gutzeit A, Pless M. Two cases of cerebral sinus venous thrombosis following chemotherapy for non-seminomatous germ cell tumor. Case Rep Oncol. 2011;4(3):555–9.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Payne JH, Vora JA. Thrombosis and acute lymphoblastic leukaemia. Br J Haematol. 2007;138(4):430–45.

    Article  PubMed  Google Scholar 

  • Ross CS, Brown TM, Kotagal S, Rodriguez V. Cerebral venous sinus thrombosis in pediatric cancer patients: long-term neurological outcomes. J Pediatr Hematol Oncol. 2013;35(4):299–302.

    Article  PubMed  Google Scholar 

  • Truelove E, Fielding AK, Hunt BJ. The coagulopathy and thrombotic risk associated with L-asparaginase treatment in adults with acute lymphoblastic leukaemia. Leukemia. 2013;27(3):553–9.

    Article  CAS  PubMed  Google Scholar 

  • Wani NA, Kosar T, Pala NA, Qureshi UA. Sagittal sinus thrombosis due to L-asparaginase. J Pediatr Neurosci. 2010;5:32–5.

    Article  PubMed Central  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Radiology, University of Massachusetts Memorial Medical Center, Worcester, MA, USA

    Rania Hito MD

  2. Department of Diagnostic Imaging, Monash Medical Center, Monash Health, Melbourne, VIC, Australia

    Ronil V. Chandra MBBS, MMed, FRANZCR

Authors
  1. Rania Hito MD
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  2. Ronil V. Chandra MBBS, MMed, FRANZCR
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Corresponding author

Correspondence to Ronil V. Chandra MBBS, MMed, FRANZCR .

Editor information

Editors and Affiliations

  1. Department of Radiology, University of Chicago, Pritzker Medical School, Chicago, Illinois, USA

    Daniel Thomas Ginat

  2. Department of Radiology, Lahey Clinic, Burlington, Massachusetts, USA

    Juan E. Small

  3. Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA

    Pamela Whitney Schaefer

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© 2015 Springer International Publishing Switzerland

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Hito, R., Chandra, R.V. (2015). L-Asparaginase (Elspar/Erwinase). In: Ginat, D., Small, J., Schaefer, P. (eds) Neuroimaging Pharmacopoeia. Springer, Cham. https://doi.org/10.1007/978-3-319-12715-6_21

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  • DOI: https://doi.org/10.1007/978-3-319-12715-6_21

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-12714-9

  • Online ISBN: 978-3-319-12715-6

  • eBook Packages: MedicineMedicine (R0)

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