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Methotrexate

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Neuroimaging Pharmacopoeia

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Abstract

Methotrexate is a folate antagonist that is used to treat acute leukemia, lymphoma, osteosarcoma, and leptomeningeal metastases. Methotrexate can be administered orally, intravenously, or intrathecally. Methotrexate given intravenously at high dose has been shown to decrease the incidence of hematologic, testicular, and central nervous system relapse.

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Suggested Reading

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Author information

Authors and Affiliations

  1. Department of Radiology, University of Chicago, Pritzker Medical School, Chicago, IL, USA

    Daniel Thomas Ginat MD, MS

Authors
  1. Daniel Thomas Ginat MD, MS
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Correspondence to Daniel Thomas Ginat MD, MS .

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Editors and Affiliations

  1. Department of Radiology, University of Chicago, Pritzker Medical School, Chicago, Illinois, USA

    Daniel Thomas Ginat

  2. Department of Radiology, Lahey Clinic, Burlington, Massachusetts, USA

    Juan E. Small

  3. Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA

    Pamela Whitney Schaefer

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© 2015 Springer International Publishing Switzerland

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Ginat, D.T. (2015). Methotrexate. In: Ginat, D., Small, J., Schaefer, P. (eds) Neuroimaging Pharmacopoeia. Springer, Cham. https://doi.org/10.1007/978-3-319-12715-6_19

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  • DOI: https://doi.org/10.1007/978-3-319-12715-6_19

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-12714-9

  • Online ISBN: 978-3-319-12715-6

  • eBook Packages: MedicineMedicine (R0)

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