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Biodegradable Natural Polymers

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Advanced Polymers in Medicine

Abstract

Natural polymers have proved to be useful in versatile applications, including controlled drug delivery, gene delivery, regenerative medicine, and other biomedical applications. These polymers are obtained primarily from plants, animals, and microbial sources which are again classified based on their chemistry into polysaccharide, protein, polyester, polyamide-based polymers. The in-depth surveys of these polymers reveals their malleable nature to be modified for various applications. Also, their responsive chemical linkages provide ease of biodegradability, which in turn makes them biocompatible. Their desirable features of ample abundance, biocompatibility, and biodegradability make them potential material for various uses. The eco-friendly profile of these polymers makes researchers inclined towards alluring natural polymers. This chapter describes natural polymers obtained from different sources and provides insights on the origin, chemistry, key features, applications, and marketed products of natural polymers that are being explored as adaptable materials in multifaceted areas.

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Abbreviations

CDs:

Cyclodextrin

HPMC:

Hydroxy propyl methyl cellulose

MCC:

Micro crystalline cellulose

GFR:

Glomerular filtration rate

DE:

Degree of esterification

SPIONs:

Super paramagnetic iron oxide nanoparticles

CaPG:

Calcium pectinate gel

KGM:

Konjac glucomannan

BSA:

Bovine serum albumin

AG:

Arabinogalactan

AGP:

Arabinogalactan protein

GAG:

Glycosaminoglycan

HA:

Hyaluronic acid

CS:

Chondroitin sulphate

ECM:

Extracellular matrix

HAS:

Hyaluronan synthases

IdoA:

l-iduronic acid

TC:

Tropocollagen

FACITs:

Fibril associated collagens with interrupted triple helices

MACITs:

Membrane associated collagens with interrupted triple helices

MULTIPLEXINS:

Multiple triple helix domains and interruptions

HSA:

Human serum albumin

EPR:

Enhanced permeability and retention effect

BMMNCs:

Bone marrow mono-nuclear cells

ADSCs:

Adipose derived stem cells

bFGF:

Basic fibroblast growth factor

FH:

Fibrin-H-chain

FL:

Fibrin-L-chain

RSF:

Regenerated silk fibroin

SFCS:

Silk fibroin chitosan scaffold

GalCS:

Galactosylated chitosan scaffold

PHA:

Poly hydroxy alkanoate

PHB:

Poly hydroxy butyrate

PHBV:

Poly (hydroxybutyrate-co-hydroxyvalerate)

PHBH:

Poly (hydroxybutyrate-co-hydroxyhexanoate)

PHBO:

Poly (hydroxybutyrate-co-hydroxyoctanoate)

sCL:

Short chain length

mCL:

Medium chain length

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Authors and Affiliations

  1. Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500037, India

    Sindhu Doppalapudi, Sameer Katiyar & Wahid Khan

  2. School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel

    Abraham J. Domb & Wahid Khan

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  1. Sindhu Doppalapudi
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  2. Sameer Katiyar
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  3. Abraham J. Domb
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  4. Wahid Khan
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Correspondence to Wahid Khan .

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  1. Pharmacy, Health and Nutritional Sci., University of Calabria, Rende, Italy

    Francesco Puoci

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Doppalapudi, S., Katiyar, S., Domb, A.J., Khan, W. (2015). Biodegradable Natural Polymers. In: Puoci, F. (eds) Advanced Polymers in Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-12478-0_2

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