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Reproductive Hormones in Epilepsy Therapy: From Old Promises to New Hopes

  • Alberto VerrottiEmail author
  • Giovanni Prezioso
  • Claudia D’Egidio
  • Vincenzo Belcastro
Chapter
Part of the Contemporary Clinical Neuroscience book series (CCNE)

Abstract

A significant mutual interaction between sex hormones and the central nervous system has been reported by several studies in the past years.

This paper aims to discuss the genomic and electrophysiological effects of androgens, estrogens and progestogens on neurons, their influence on seizure frequency and antiepileptic drugs metabolism, and, conversely, the hormonal changes and reproductive dysfunction in patients with epilepsy.

In conclusion, the correlations between Polycystic Ovary Syndrome (PCOS), reduced effectiveness of contraceptives and antiepileptic drugs have also been mentioned.

Keywords

Sex hormones Epilepsy Androgen Estrogen Progesterone Neurosteroids Catamenial epilepsy Antiepileptic drugs Sex functions PCOS Contraceptive 

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Alberto Verrotti
    • 1
    Email author
  • Giovanni Prezioso
    • 2
  • Claudia D’Egidio
    • 2
  • Vincenzo Belcastro
    • 3
  1. 1.Department of PediatricsUniversity of PerugiaPerugiaItaly
  2. 2.Department of PediatricsUniversity of ChietiChietiItaly
  3. 3.Neurology Unit, Department of MedicineS. Anna HospitalComoItaly

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