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Role of Osteopontin in Tumor Microenvironment: A New Paradigm in Cancer Therapy

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Multi-Targeted Approach to Treatment of Cancer

Abstract

Cancer is a complex, multifactorial disease, emerged due to dysregulation of one or more cellular signaling cascades by somatic or germ line mutations. However, tumor progression vastly depends on context-dependent interaction between cancer cells and its surrounding microenvironment. Tumor microenvironment plays multifaceted role in tumor progression by providing not only a structural framework but also proliferative, metastatic, and angiogenic signals. It is well established that array of growth factors, cytokines, and chemokines acts at the interface of tumor and stromal cells. Osteopontin (OPN), a chemokine-like protein, is overexpressed in various tumor tissues and cell lines. It has immense potential to regulate various hallmarks of cancer. Presumably, targeting the communication between the tumor cells and surrounding microenvironment using specific antibodies, small molecule inhibitors, and chemotherapeutic agents by exploiting OPN as a central molecule are novel therapeutic strategies for management of cancer.

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Acknowledgment

The author’s research is supported in part by Department of Biotechnology, Department of Science and Technology, and Council of Scientific and Industrial Research, Government of India. We apologize to the many authors whose contributions we could not cite because of limitation of space.

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Authors and Affiliations

  1. National Centre for Cell Science, NCCS Complex, Pune, 411007, India

    Ramesh Butti, Pompom Ghosh, Kumar V. S. Totakura, Radharani N. Naga Venkata, Ramakrishna Nimma & Gopal C. Kundu

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  1. Ramesh Butti
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  2. Pompom Ghosh
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  3. Kumar V. S. Totakura
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  4. Radharani N. Naga Venkata
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  5. Ramakrishna Nimma
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  6. Gopal C. Kundu
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Corresponding author

Correspondence to Gopal C. Kundu .

Editor information

Editors and Affiliations

  1. Department of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    Varsha Gandhi

  2. Department of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    Kapil Mehta

  3. Delhi State Cancer Institute (East), Delhi, India

    Rajesh Grover

  4. Department of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    Sen Pathak

  5. Department of Bioimmunotherapy, Section of Cytokine Research, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    Bharat B. Aggarwal

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Butti, R., Ghosh, P., Totakura, K.V.S., Venkata, R.N.N., Nimma, R., Kundu, G.C. (2015). Role of Osteopontin in Tumor Microenvironment: A New Paradigm in Cancer Therapy. In: Gandhi, V., Mehta, K., Grover, R., Pathak, S., Aggarwal, B. (eds) Multi-Targeted Approach to Treatment of Cancer. Adis, Cham. https://doi.org/10.1007/978-3-319-12253-3_6

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