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Tumor-Associated Macrophages in Tumor Progression: From Bench to Bedside

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Multi-Targeted Approach to Treatment of Cancer

Abstract

Cancer-related inflammation is known to be a key determinant in cancer behavior, playing a pivotal role in cancer initiation and progression. Tumor-associated macrophages (TAM) represent the major leukocyte population among the tumor-infiltrating immune cells and display important and peculiar features. Within the tumor microenvironment, TAM may modulate their phenotype in response to distinct signals, resulting in a strict relationship with tumor cells. This plasticity confers the capability to change their behavior and reprogram their functions according to physiological or pathological situations. From a simplistic point of view, macrophages may be classified in M1 classical and M2 alternative macrophages, the latter displaying an immunomodulatory phenotype. M1 and M2 macrophages take part in different processes, such as resistance against pathogens and antitumor immunity or defense against parasites and resolution of inflammation, respectively. However, in addition to these, a number of functional diverse polarization states have been described. Several evidences indicate that in many tumors, macrophages display phenotypic and functional aspects that resemble M2 cells, which overall promote tumor initiation and progression. However, heterogeneity exists among TAM. In this scenario, TAM represent a possible target to improve anticancer therapy.

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Acknowledgments

Alberto Mantovani is supported by the Italian Ministry of Health and by ERC. Maria Rosaria Galdiero is supported by a fellowship from P.O.R. Campania FSE 2007–2013, Project “CREMe”.

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Authors and Affiliations

  1. Humanitas Clinical and Research Center, via Manzoni 56, Rozzano, MI, 20089, Italy

    Maria Rosaria Galdiero & Alberto Mantovani

  2. Division of Clinical Immunology and Allergy, University of Naples Federico II, via Pansini 5, Naples, 80131, Italy

    Maria Rosaria Galdiero

  3. Department of Biotechnology and Translational Medicine, University of Milan, Rozzano, MI, 20089, Italy

    Alberto Mantovani

Authors
  1. Maria Rosaria Galdiero
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  2. Alberto Mantovani
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Corresponding author

Correspondence to Alberto Mantovani .

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Editors and Affiliations

  1. Department of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    Varsha Gandhi

  2. Department of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    Kapil Mehta

  3. Delhi State Cancer Institute (East), Delhi, India

    Rajesh Grover

  4. Department of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    Sen Pathak

  5. Department of Bioimmunotherapy, Section of Cytokine Research, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    Bharat B. Aggarwal

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Galdiero, M.R., Mantovani, A. (2015). Tumor-Associated Macrophages in Tumor Progression: From Bench to Bedside. In: Gandhi, V., Mehta, K., Grover, R., Pathak, S., Aggarwal, B. (eds) Multi-Targeted Approach to Treatment of Cancer. Adis, Cham. https://doi.org/10.1007/978-3-319-12253-3_5

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