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Genome-Based Multi-targeting of Cancer: Hype or Hope?

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Multi-Targeted Approach to Treatment of Cancer

Abstract

Cancer is primarily an “old-age disease” that has an “age-old” history. The overall incidence of cancer is much higher in Western countries than in Eastern countries for reasons that are not understood. Almost three million studies published to date indicate that cancer is a hyperproliferative disorder that arises from dysregulation of multiple cell signaling pathways. The cancer genome landscape indicates that approximately 140 genes and 12 cell signaling pathways drive almost all types of cancers. “Targeted therapy,” a buzz word in cancer treatment for the past two decades, has provided antibodies as well as small-molecule inhibitors of ligands, receptors, kinases, proteasomes, and transcription factors. In most cases, such drugs have been highly ineffective, with overall increases in survival of only few days; furthermore, in most cases, those who need these drugs cannot afford them. Natural products, in contrast, are often more effective against cancer and are very affordable; these untargeted or multitargeted products have been used from the very beginning of human history and are the roots for almost 70 % of modern drugs. The past, present, and future of preventing and treating cancer, usually a disease of lifestyle, is discussed in this mini review.

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References

  • Aggarwal BB (2003) Signalling pathways of the TNF superfamily: a double-edged sword. Nat Rev Immunol 3:745–756

    CAS  PubMed  Google Scholar 

  • Aggarwal BB (2004) Nuclear factor-kappaB: the enemy within. Cancer Cell 6:203–208

    CAS  PubMed  Google Scholar 

  • Aggarwal BB (2005) Nuclear factor -kB as target for chemoprevention. In: Surh Y-J, Packer L (eds) Oxidative stress, inflammation, and health. CRC Press, Boca Raton, pp 107–126

    Google Scholar 

  • Aggarwal BB (2008) The past, present and future of multi-targeted cancer treatment “naturally”: food for thought. Cancer Lett 269:187–188

    CAS  PubMed  Google Scholar 

  • Aggarwal BB (2009) Inflammation, a silent killer in cancer is not so silent! Curr Opin Pharmacol 9:347–350

    CAS  PubMed  Google Scholar 

  • Aggarwal BB (2010) Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals. Annu Rev Nutr 30:173–199

    CAS  PubMed Central  PubMed  Google Scholar 

  • Aggarwal BB, Harikumar KB (2009) Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol 41:40–59

    CAS  PubMed Central  PubMed  Google Scholar 

  • Aggarwal BB, Kunnumakkara AB (2009) Molecular targets and therapeutic uses of spices: modern uses for ancient medicine. World scientific publishing group, Singapore, pp 1–430

    Google Scholar 

  • Aggarwal BB, Shishodia S (2004) Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning. Ann N Y Acad Sci 1030:434–441

    CAS  PubMed  Google Scholar 

  • Aggarwal BB, Sung B (2009) Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends Pharmacol Sci 30:85–94

    CAS  PubMed  Google Scholar 

  • Aggarwal BB, Sung B (2011) NF-kappaB in cancer: a matter of life and death. Cancer Discov 1:469–471

    CAS  PubMed Central  PubMed  Google Scholar 

  • Aggarwal BB, Kumar A, Bharti AC (2003) Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res 23:363–398

    CAS  PubMed  Google Scholar 

  • Aggarwal BB, Kumar A, Bharti AC (2004) Therapeutic potential of curcumin derived from turmeric (Curcuma longa). In: Packer L, Ong CN, Halliwell B (eds) Herbal and traditional medicine: molecular aspects of health. Marcel Dekker, New York, pp 781–812

    Google Scholar 

  • Aggarwal BB, Sethi G, Nair A, Ichikawa H (2006) Nuclear Factor-kB: Aholy grail in cancer prevention and therapy. Curr Signal Transduct Ther 10(1):25–52

    Google Scholar 

  • Aggarwal BB, Sethi G, Baladandayuthapani V, Krishnan S, Shishodia S (2007) Targeting cell signaling pathways for drug discovery: an old lock needs a new key. J Cell Biochem 102:580–592

    CAS  PubMed  Google Scholar 

  • Aggarwal BB, Danda D, Sung B (2008) Targeting inflammatory pathways for prevention and treatment of chronic diseases by phytochemicals derived from traditional remedies. In: Proceedings of international conference on new developments in drug discovery from natural products and traditional medicine, India, pp 56–67

    Google Scholar 

  • Aggarwal BB, Kunnumakkara AB, Harikumar KB, Tharakan ST, Sung B, Anand P (2008b) Potential of spice-derived phytochemicals for cancer prevention. Planta Med 74:1560–1569

    CAS  PubMed  Google Scholar 

  • Aggarwal BB, Van Kuiken ME, Iyer LH, Harikumar KB, Sung B (2009a) Molecular targets of nutraceuticals derived from dietary spices: potential role in suppression of inflammation and tumorigenesis. Exp Biol Med (Maywood) 234:825–849

    CAS  Google Scholar 

  • Aggarwal BB, Kunnumakkara AB, Harikumar KB, Gupta SR, Tharakan ST, Koca C, Dey S, Sung B (2009b) Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship? Ann N Y Acad Sci 1171:59–76

    CAS  PubMed Central  PubMed  Google Scholar 

  • Aggarwal BB, Sundaram C, Prasad S, Kannappan R (2010) Tocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic diseases. Biochem Pharmacol 80:1613–1631

    CAS  PubMed Central  PubMed  Google Scholar 

  • Aggarwal BB, Gupta SC, Sung B (2013a) Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers. Br J Pharmacol 169:1672–1692

    CAS  PubMed Central  PubMed  Google Scholar 

  • Aggarwal BB, Yuan W, Li S, Gupta SC (2013b) Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: identification of novel components of turmeric. Mol Nutr Food Res 57:1529–1542

    CAS  PubMed  Google Scholar 

  • Aggarwal BB, Prasad S, Sung B, Krishnan S, Guha S (2013c) Prevention and treatment of colorectal cancer by natural agents from mother nature. Curr Colorectal Cancer Rep 9:1–20

    Google Scholar 

  • Ahn KS, Sethi G, Aggarwal BB (2007) Nuclear factor-kappa B: from clone to clinic. Curr Mol Med 7:619–637

    CAS  PubMed  Google Scholar 

  • Ahn KS, Sethi G, Aggarwal BB (2008) Reversal of chemoresistance and enhancement of apoptosis by statins through down-regulation of the NF-kappaB pathway. Biochem Pharmacol 75:907–913

    CAS  PubMed Central  PubMed  Google Scholar 

  • Akavia UD, Litvin O, Kim J, Sanchez-Garcia F, Kotliar D, Causton HC, Pochanard P, Mozes E, Garraway LA, Pe’er D (2010) An integrated approach to uncover drivers of cancer. Cell 143:1005–1017

    CAS  PubMed Central  PubMed  Google Scholar 

  • Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB (2007) Bioavailability of curcumin: problems and promises. Mol Pharm 4:807–818

    CAS  PubMed  Google Scholar 

  • Anand P, Kunnumakkara AB, Sundaram C, Harikumar KB, Tharakan ST, Lai OS, Sung B, Aggarwal BB (2008a) Cancer is a preventable disease that requires major lifestyle changes. Pharm Res 25:2097–2116

    CAS  PubMed Central  PubMed  Google Scholar 

  • Anand P, Thomas SG, Kunnumakkara AB, Sundaram C, Harikumar KB, Sung B, Tharakan ST, Misra K, Priyadarsini IK, Rajasekharan KN, Aggarwal BB (2008b) Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature. Biochem Pharmacol 76:1590–1611

    CAS  PubMed  Google Scholar 

  • Balachandran P, Govindarajan R (2005) Cancer–an ayurvedic perspective. Pharmacol Res 51:19–30

    PubMed  Google Scholar 

  • Bernards R, Weinberg RA (2002) A progression puzzle. Nature 418:823

    CAS  PubMed  Google Scholar 

  • Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J, Barretina J, Boehm JS, Dobson J, Urashima M et al (2010) The landscape of somatic copy-number alteration across human cancers. Nature 463:899–905

    CAS  PubMed Central  PubMed  Google Scholar 

  • Bozic I, Antal T, Ohtsuki H, Carter H, Kim D, Chen S, Karchin R, Kinzler KW, Vogelstein B, Nowak MA (2010) Accumulation of driver and passenger mutations during tumor progression. Proc Natl Acad Sci U S A 107:18545–18550

    CAS  PubMed Central  PubMed  Google Scholar 

  • Chen Y, Hao J, Jiang W, He T, Zhang X, Jiang T, Jiang R (2013) Identifying potential cancer driver genes by genomic data integration. Sci Rep 3:3538

    PubMed Central  PubMed  Google Scholar 

  • Dalgliesh GL, Furge K, Greenman C, Chen L, Bignell G, Butler A, Davies H, Edkins S, Hardy C, Latimer C et al (2010) Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature 463:360–363

    CAS  PubMed Central  PubMed  Google Scholar 

  • Delhommeau F, Dupont S, Della Valle V, James C, Trannoy S, Masse A, Kosmider O, Le Couedic JP, Robert F, Alberdi A et al (2009) Mutation in TET2 in myeloid cancers. N Engl J Med 360:2289–2301

    PubMed  Google Scholar 

  • Deorukhkar A, Krishnan S, Sethi G, Aggarwal BB (2007) Back to basics: how natural products can provide the basis for new therapeutics. Expert Opin Investig Drugs 16:1753–1773

    CAS  PubMed  Google Scholar 

  • Doonan JH, Sablowski R (2010) Walls around tumours – why plants do not develop cancer. Nat Rev Cancer 10:794–802

    CAS  PubMed  Google Scholar 

  • Dorai T, Aggarwal BB (2004) Role of chemopreventive agents in cancer therapy. Cancer Lett 215:129–140

    CAS  PubMed  Google Scholar 

  • Dunn BK, Jegalian K, Greenwald P (2011) Biomarkers for early detection and as surrogate endpoints in cancer prevention trials: issues and opportunities. Recent Results Cancer Res 188:21–47

    CAS  PubMed  Google Scholar 

  • Farmer H, McCabe N, Lord CJ, Tutt AN, Johnson DA, Richardson TB, Santarosa M, Dillon KJ, Hickson I, Knights C et al (2005) Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434:917–921

    CAS  PubMed  Google Scholar 

  • Fearon ER, Vogelstein B (1990) A genetic model for colorectal tumorigenesis. Cell 61:759–767

    CAS  PubMed  Google Scholar 

  • Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127:2893–2917

    CAS  PubMed  Google Scholar 

  • Fiszman GL, Jasnis MA (2011) Molecular Mechanisms of Trastuzumab Resistance in HER2 Overexpressing Breast Cancer. Int J Breast Cancer 2011:352182

    PubMed Central  PubMed  Google Scholar 

  • Fojo T, Parkinson DR (2010) Biologically targeted cancer therapy and marginal benefits: are we making too much of too little or are we achieving too little by giving too much? Clin Cancer Res 16:5972–5980

    CAS  PubMed  Google Scholar 

  • Futreal PA, Coin L, Marshall M, Down T, Hubbard T, Wooster R, Rahman N, Stratton MR (2004) A census of human cancer genes. Nat Rev Cancer 4:177–183

    CAS  PubMed Central  PubMed  Google Scholar 

  • Garodia P, Ichikawa H, Malani N, Sethi G, Aggarwal BB (2007) From ancient medicine to modern medicine: ayurvedic concepts of health and their role in inflammation and cancer. J Soc Integr Oncol 5:25–37

    PubMed  Google Scholar 

  • Goel A, Aggarwal BB (2010) Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs. Nutr Cancer 62:919–930

    CAS  PubMed  Google Scholar 

  • Goel A, Kunnumakkara AB, Aggarwal BB (2008a) Curcumin as “Curecumin”: from kitchen to clinic. Biochem Pharmacol 75:787–809

    CAS  PubMed  Google Scholar 

  • Goel A, Jhurani S, Aggarwal BB (2008b) Multi-targeted therapy by curcumin: how spicy is it? Mol Nutr Food Res 52:1010–1030

    CAS  PubMed  Google Scholar 

  • Goss PE, Strasser-Weippl K, Lee-Bychkovsky BL, Fan L, Li J, Chavarri-Guerra Y, Liedke PE, Pramesh CS, Badovinac-Crnjevic T, Sheikine Y et al (2014) Challenges to effective cancer control in China, India, and Russia. Lancet Oncol 15:489–538

    PubMed  Google Scholar 

  • Govindan R, Ding L, Griffith M, Subramanian J, Dees ND, Kanchi KL, Maher CA, Fulton R, Fulton L, Wallis J et al (2012) Genomic landscape of non-small cell lung cancer in smokers and never-smokers. Cell 150:1121–1134

    CAS  PubMed Central  PubMed  Google Scholar 

  • Gryfe R, Gallinger S (2001) Microsatellite instability, mismatch repair deficiency, and colorectal cancer. Surgery 130:17–20

    CAS  PubMed  Google Scholar 

  • Gullett NP, Ruhul Amin AR, Bayraktar S, Pezzuto JM, Shin DM, Khuri FR, Aggarwal BB, Surh YJ, Kucuk O (2010) Cancer prevention with natural compounds. Semin Oncol 37:258–281

    CAS  PubMed  Google Scholar 

  • Gupta SC, Kim JH, Prasad S, Aggarwal BB (2010) Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer Metastasis Rev 29:405–434

    CAS  PubMed Central  PubMed  Google Scholar 

  • Gupta SC, Prasad S, Kim JH, Patchva S, Webb LJ, Priyadarsini IK, Aggarwal BB (2011) Multitargeting by curcumin as revealed by molecular interaction studies. Nat Prod Rep 28:1937–1955

    CAS  PubMed Central  PubMed  Google Scholar 

  • Gupta SC, Patchva S, Koh W, Aggarwal BB (2012) Discovery of curcumin, a component of golden spice, and its miraculous biological activities. Clin Exp Pharmacol Physiol 39:283–299

    CAS  PubMed Central  PubMed  Google Scholar 

  • Gupta SC, Sung B, Kim JH, Prasad S, Li S, Aggarwal BB (2013a) Multitargeting by turmeric, the golden spice: from kitchen to clinic. Mol Nutr Food Res 57:1510–1528

    CAS  PubMed  Google Scholar 

  • Gupta SC, Kismali G, Aggarwal BB (2013b) Curcumin, a component of turmeric: from farm to pharmacy. Biofactors 39:2–13

    CAS  PubMed  Google Scholar 

  • Gupta SC, Sung B, Prasad S, Webb LJ, Aggarwal BB (2013c) Cancer drug discovery by repurposing: teaching new tricks to old dogs. Trends Pharmacol Sci 34:508–517

    CAS  PubMed  Google Scholar 

  • Hajdu SI (2011a) A note from history: landmarks in history of cancer, part 1. Cancer 117(5):1097–1102

    PubMed  Google Scholar 

  • Hajdu SI (2011b) A note from history: landmarks in history of cancer, part 2. Cancer 117(12):2811–2820

    PubMed  Google Scholar 

  • Hajdu SI (2012a) A note from history: landmarks in history of cancer, part 3. Cancer 118(4):1155–1168

    PubMed  Google Scholar 

  • Hajdu SI (2012b) A note from history: landmarks in history of cancer, part 4. Cancer 118(20):4914–4928

    PubMed  Google Scholar 

  • Hajdu SI, Darvishian F (2013) A note from history: landmarks in history of cancer, part 5. Cancer 119(8):1450–1466

    PubMed  Google Scholar 

  • Hajdu SI, Vadmal M (2013) A note from history: landmarks in history of cancer, part 6. Cancer 119(23):4058–4082

    PubMed  Google Scholar 

  • Harvey AM (1974) Early contributions to the surgery of cancer: William S. Halsted, Hugh H. Young and John G. Clark. Johns Hopkins Med J 135:399–417

    CAS  PubMed  Google Scholar 

  • Hasima N, Aggarwal BB (2014) Targeting proteasomal pathways by dietary curcumin for cancer prevention and treatment. Curr Med Chem 21:1583–1594

    CAS  PubMed  Google Scholar 

  • Herr HW, Dalbagni G, Donat SM (2011) Bacillus Calmette-Guerin without maintenance therapy for high-risk non-muscle-invasive bladder cancer. Eur Urol 60:32–36

    PubMed  Google Scholar 

  • Jones S, Chen WD, Parmigiani G, Diehl F, Beerenwinkel N, Antal T, Traulsen A, Nowak MA, Siegel C, Velculescu VE et al (2008) Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci U S A 105:4283–4288

    CAS  PubMed Central  PubMed  Google Scholar 

  • Kamat AM, Tharakan ST, Sung B, Aggarwal BB (2009) Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer through the downregulation of NF-kappaB and upregulation of TRAIL receptors. Cancer Res 69:8958–8966

    CAS  PubMed  Google Scholar 

  • Kantarjian HM, Fojo T, Mathisen M, Zwelling LA (2013) Cancer drugs in the United States: Justum Pretium–the just price. J Clin Oncol 31:3600–3604

    PubMed Central  PubMed  Google Scholar 

  • Kerbel RS (1990) Growth dominance of the metastatic cancer cell: cellular and molecular aspects. Adv Cancer Res 55:87–132

    CAS  PubMed  Google Scholar 

  • Kidd JM, Graves T, Newman TL, Fulton R, Hayden HS, Malig M, Kallicki J, Kaul R, Wilson RK, Eichler EE (2010) A human genome structural variation sequencing resource reveals insights into mutational mechanisms. Cell 143:837–847

    CAS  PubMed Central  PubMed  Google Scholar 

  • Kim EB, Fang X, Fushan AA, Huang Z, Lobanov AV, Han L, Marino SM, Sun X, Turanov AA, Yang P et al (2011) Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature 479:223–227

    CAS  PubMed Central  PubMed  Google Scholar 

  • Kinzler KW, Vogelstein B (1997) Cancer-susceptibility genes. Gatekeepers and caretakers. Nature 386:761, 763

    CAS  PubMed  Google Scholar 

  • Koboldt DC, Zhang Q, Larson DE, Shen D, McLellan MD, Lin L, Miller CA, Mardis ER, Ding L, Wilson RK (2012) VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing. Genome Res 22:568–576

    CAS  PubMed Central  PubMed  Google Scholar 

  • Kolonel LN, Altshuler D, Henderson BE (2004) The multiethnic cohort study: exploring genes, lifestyle and cancer risk. Nat Rev Cancer 4:519–527

    CAS  PubMed  Google Scholar 

  • Kunnumakkara AB, Aggarwal BB (2007/2008) Chemoprevention of GI cancers with dietary agents. Are we there yet? AGA perspectives 8–10

    Google Scholar 

  • Kunnumakkara AB, Anand P, Aggarwal BB (2008) Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Lett 269:199–225

    CAS  PubMed  Google Scholar 

  • Kunnumakkara AB, Koca K, Dey S, Gehlot P, Yotkhiri S, Danda D, Sung B, Aggarwal BB (2009) Traditional uses of spices: an overview. In: Aggarwal BB, Kunnumakkara AB (eds) Molecular targets and therapeutic uses of spices: modern uses for ancient medicine. World Scientific Publishing Company, Singapore, pp 281–310

    Google Scholar 

  • Kwak EL, Bang YJ, Camidge DR, Shaw AT, Solomon B, Maki RG, Ou SH, Dezube BJ, Janne PA, Costa DB et al (2010) Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med 363:1693–1703

    CAS  PubMed Central  PubMed  Google Scholar 

  • Latosińska JN, Latosińska M (2013) Anticancer drug discovery – from serendipity to rational design. In: Hany El-Shemy (ed) Drug discovery. InTech, ISBN: 978-953-951-0906-0908.

    Google Scholar 

  • Laurenti E, Dick JE (2012) Molecular and functional characterization of early human hematopoiesis. Ann N Y Acad Sci 1266:68–71

    CAS  PubMed  Google Scholar 

  • Lemmon MA, Schlessinger J (2010) Cell signaling by receptor tyrosine kinases. Cell 141:1117–1134

    CAS  PubMed Central  PubMed  Google Scholar 

  • Ley TJ, Ding L, Walter MJ, McLellan MD, Lamprecht T, Larson DE, Kandoth C, Payton JE, Baty J, Welch J et al (2010) DNMT3A mutations in acute myeloid leukemia. N Engl J Med 363:2424–2433

    CAS  PubMed Central  PubMed  Google Scholar 

  • McCarthy EF (2006) The toxins of William B. Coley and the treatment of bone and soft-tissue sarcomas. Iowa Orthop J 26:154–158

    PubMed Central  PubMed  Google Scholar 

  • Mitra A, Chakraborty S, Auddy B, Tripathi P, Sen S, Saha AV, Mukherjee B (2002) Evaluation of chemical constituents and free-radical scavenging activity of Swarnabhasma (gold ash), an ayurvedic drug. J Ethnopharmacol 80:147–153

    CAS  PubMed  Google Scholar 

  • Morales A, Eidinger D, Bruce AW (2002) Intracavitary Bacillus Calmette-Guerin in the treatment of superficial bladder tumors. 1976. J Urol 167:891–893; discussion 893–895

    CAS  PubMed  Google Scholar 

  • Nair HB, Sung B, Yadav VR, Kannappan R, Chaturvedi MM, Aggarwal BB (2010) Delivery of antiinflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer. Biochem Pharmacol 80:1833–1843

    CAS  PubMed Central  PubMed  Google Scholar 

  • Newman DJ, Cragg GM (2012) Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod 75:311–335

    CAS  PubMed Central  PubMed  Google Scholar 

  • Nowell PC (1976) The clonal evolution of tumor cell populations. Science 194:23–28

    CAS  PubMed  Google Scholar 

  • Palles C, Cazier JB, Howarth KM, Domingo E, Jones AM, Broderick P, Kemp Z, Spain SL, Guarino E, Salguero I et al (2013) Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas. Nat Genet 45:136–144

    CAS  PubMed Central  PubMed  Google Scholar 

  • Pandey MK, Kunnumakkara AB, Aggarwal BB (2009) Kokum (Garcinol). In: Aggarwal BB, Kunnumakkara AB (eds) Molecular targets and therapeutic uses of spices: modern uses for ancient medicine. World Scientific Publishing Company, Singapore, pp 281–310

    Google Scholar 

  • Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Siu IM, Gallia GL et al (2008) An integrated genomic analysis of human glioblastoma multiforme. Science 321:1807–1812

    CAS  PubMed Central  PubMed  Google Scholar 

  • Prasad S, Tyagi AK, Aggarwal BB (2014) Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice. Cancer Res Treat 46:2–18

    PubMed Central  PubMed  Google Scholar 

  • Ralhan R, Pandey MK, Aggarwal BB (2009) Nuclear factor-kappa B links carcinogenic and chemopreventive agents. Front Biosci (Schol Ed) 1:45–60

    Google Scholar 

  • Reuter S, Gupta SC, Park B, Goel A, Aggarwal BB (2011) Epigenetic changes induced by curcumin and other natural compounds. Genes Nutr 6:93–108

    CAS  PubMed Central  PubMed  Google Scholar 

  • Rhoades ER, Rhoades DA (2014) The public health foundation of health services for American Indians & Alaska Natives. Am J Public Health 104(Suppl 3):S278–S285

    PubMed Central  PubMed  Google Scholar 

  • Santarius T, Shipley J, Brewer D, Stratton MR, Cooper CS (2010) A census of amplified and overexpressed human cancer genes. Nat Rev Cancer 10:59–64

    CAS  PubMed  Google Scholar 

  • Schnipper LE, Meropol NJ, Brock DW (2010) Value and cancer care: toward an equitable future. Clin Cancer Res 16:6004–6008

    PubMed  Google Scholar 

  • Schwartzentruber J, Korshunov A, Liu XY, Jones DT, Pfaff E, Jacob K, Sturm D, Fontebasso AM, Quang DA, Tonjes M et al (2012) Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature 482:226–231

    CAS  PubMed  Google Scholar 

  • Sethi G, Sung B, Aggarwal BB (2008) Nuclear factor-kappaB activation: from bench to bedside. Exp Biol Med (Maywood) 233:21–31

    CAS  Google Scholar 

  • Sharma SV, Bell DW, Settleman J, Haber DA (2007) Epidermal growth factor receptor mutations in lung cancer. Nat Rev Cancer 7:169–181

    CAS  PubMed  Google Scholar 

  • Shishodia S, Aggarwal BB (2004) Nuclear factor-kappaB: a friend or a foe in cancer? Biochem Pharmacol 68:1071–1080

    CAS  PubMed  Google Scholar 

  • Shishodia S, Chaturvedi MM, Aggarwal BB (2007) Role of curcumin in cancer therapy. Curr Probl Cancer 31:243–305

    PubMed  Google Scholar 

  • Shishodia S, Harikumar KB, Dass S, Ramawat KG, Aggarwal BB (2008a) The guggul for chronic diseases: ancient medicine, modern targets. Anticancer Res 28:3647–3664

    CAS  PubMed  Google Scholar 

  • Shishodia S, Misra K, Aggarwal BB (2008b) Turmeric as cure (cumin): promises, problems and solutions. In: Surh YJ, Dong Z, Cadenas E, Packer L (eds) Dietary modulation of cell signaling pathways. CRC Press, Boca Raton

    Google Scholar 

  • Sinha D, Biswas J, Sung B, Aggarwal BB, Bishayee A (2012) Chemopreventive and chemotherapeutic potential of curcumin in breast cancer. Curr Drug Targets 13:1799–1819

    CAS  PubMed  Google Scholar 

  • Stratton MR, Campbell PJ, Futreal PA (2009) The cancer genome. Nature 458:719–724

    CAS  PubMed Central  PubMed  Google Scholar 

  • Sung B, Prasad S, Yadav VR, Aggarwal BB (2012) Cancer cell signaling pathways targeted by spice-derived nutraceuticals. Nutr Cancer 64:173–197

    CAS  PubMed Central  PubMed  Google Scholar 

  • Tallman MS, Altman JK (2008) Curative strategies in acute promyelocytic leukemia. Hematol Am Soc Hematol Educ Program 1:391–399

    Google Scholar 

  • Tomasetti C, Vogelstein B, Parmigiani G (2013) Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation. Proc Natl Acad Sci U S A 110:1999–2004

    CAS  PubMed Central  PubMed  Google Scholar 

  • Vogelstein B, Papadopoulos N, Velculescu VE, Zhou S, Diaz LA Jr, Kinzler KW (2013) Cancer genome landscapes. Science 339:1546–1558

    CAS  PubMed Central  PubMed  Google Scholar 

  • Welch JS, Ley TJ, Link DC, Miller CA, Larson DE, Koboldt DC, Wartman LD, Lamprecht TL, Liu F, Xia J et al (2012) The origin and evolution of mutations in acute myeloid leukemia. Cell 150:264–278

    CAS  PubMed Central  PubMed  Google Scholar 

  • Wood LD, Parsons DW, Jones S, Lin J, Sjoblom T, Leary RJ, Shen D, Boca SM, Barber T, Ptak J et al (2007) The genomic landscapes of human breast and colorectal cancers. Science 318:1108–1113

    CAS  PubMed  Google Scholar 

  • Wu G, Broniscer A, McEachron TA, Lu C, Paugh BS, Becksfort J, Qu C, Ding L, Huether R, Parker M et al (2012) Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. Nat Genet 44:251–253

    CAS  PubMed Central  PubMed  Google Scholar 

  • Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, Yuan W, Kos I, Batinic-Haberle I, Jones S, Riggins GJ et al (2009) IDH1 and IDH2 mutations in gliomas. N Engl J Med 360:765–773

    CAS  PubMed Central  PubMed  Google Scholar 

  • Yokota J (2000) Tumor progression and metastasis. Carcinogenesis 21:497–503

    CAS  PubMed  Google Scholar 

  • Yu M, Stott S, Toner M, Maheswaran S, Haber DA (2011) Circulating tumor cells: approaches to isolation and characterization. J Cell Biol 192:373–382

    CAS  PubMed Central  PubMed  Google Scholar 

  • Zhao S, Lin Y, Xu W, Jiang W, Zha Z, Wang P, Yu W, Li Z, Gong L, Peng Y et al (2009) Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science 324:261–265

    CAS  PubMed Central  PubMed  Google Scholar 

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Authors and Affiliations

  1. Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, 77054, USA

    Shinjini Singh, Amit Kumar Tyagi, Sasha Raman, Jiamin Huang, Lokesh Deb, Qaisar Manzoor, Arfaa Sajid, LiXin Yang, Jagnyeswar Ratha & Sahdeo Prasad

  2. Department of Bioimmunotherapy, Section of Cytokine Research, University of Texas, M.D. Anderson Cancer Center, Houston, Texas, 77054, USA

    Bharat B. Aggarwal

Authors
  1. Shinjini Singh
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  2. Amit Kumar Tyagi
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  3. Sasha Raman
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  4. Jiamin Huang
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  5. Lokesh Deb
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  6. Qaisar Manzoor
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  7. Arfaa Sajid
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  8. LiXin Yang
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  9. Jagnyeswar Ratha
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  10. Sahdeo Prasad
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  11. Bharat B. Aggarwal
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Corresponding author

Correspondence to Bharat B. Aggarwal .

Editor information

Editors and Affiliations

  1. Department of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    Varsha Gandhi

  2. Department of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    Kapil Mehta

  3. Delhi State Cancer Institute (East), Delhi, India

    Rajesh Grover

  4. Department of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    Sen Pathak

  5. Department of Bioimmunotherapy, Section of Cytokine Research, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    Bharat B. Aggarwal

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Singh, S. et al. (2015). Genome-Based Multi-targeting of Cancer: Hype or Hope?. In: Gandhi, V., Mehta, K., Grover, R., Pathak, S., Aggarwal, B. (eds) Multi-Targeted Approach to Treatment of Cancer. Adis, Cham. https://doi.org/10.1007/978-3-319-12253-3_2

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