The Many Faces of Prolactin in Breast Cancer

  • Wen Y ChenEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 846)


Prolactin (PRL) is a neuroendocrine polypeptide hormone primarily produced by the lactotrophs in the anterior pituitary gland of all vertebrates. The physiological role of PRL in mammary glands is relatively certain while its role in breast tumor has been a topic of debate for over 20 years. In this review, the author attempts to briefly summarize the data coming from his laboratory in the past years, focusing on G129R, a PRL receptor (PRLR) antagonist developed by introducing a single amino acid substitution mutation into human PRL (hPRL) at position 129, and a variety of G129R derivatives. The author has proposed two novel ideas for potential use of PRL, not anti-PRL agents, as an adjuvant agent for breast cancer, making it a hormone of many faces.


Breast Cancer Mammary Gland Breast Cancer Cell Line Breast CSCs Breast Cancer Etiology 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Adult stem cell


Cancer stem cell


Enzyme-linked immunosorbent assay


Growth hormone


Growth hormone receptor


Human prolactin


Human umbilical vein endothelial cell






Metallothionein promoter






Prolactin receptor


Quantitative polymerase chain reaction



The author wishes to thank all of his former and current laboratory members for their contributions to this work. The author also wants to apologize to those colleagues whose important work was not cited due to either space limits or oversights. Special thanks goes to Dr. John Langenheim for his critical reading of this manuscript. The author is in debt to Dr. Nian-yi Chen for her long-time support and significant contributions both in PRL as well as in GH antagonist projects. Last but not least, the author would like to thank Cynthia Chen for her help in proofreading the manuscript.


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Department of Biological SciencesClemson University, Greenville Health SystemGreenvilleUSA

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