Prolactin (PRL) in Adipose Tissue: Regulation and Functions

  • Nira Ben-JonathanEmail author
  • Eric Hugo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 846)


New information concerning the effects of prolactin (PRL) on metabolic processes warrants reevaluation of its overall metabolic actions. PRL affects metabolic homeostasis by regulating key enzymes and transporters associated with glucose and lipid metabolism in several target organs. In the lactating mammary gland, PRL increases the production of milk proteins, lactose, and lipids. In adipose tissue, PRL generally suppresses lipid storage and adipokine release and affect adipogenesis. A specific case is made for PRL in the human breast and adipose tissues, where it acts as a circulating hormone and an autocrine/paracrine factor. Although its overall effects on body composition are both modest and species-specific, PRL may be involved in the manifestation of insulin resistance.


Brown Adipocyte Hormone Sensitive Lipase LS14 Cell Lactate Mammary Gland Adipose Tissue Explants 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by NIH grants ES02909 and CA096613, DOD grants BC05725 and AR110050, CCTST, and Ride Cincinnati Pilot Grants


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Department of Cancer BiologyUniversity of CincinnatiCincinnatiUSA

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