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Secondary Metabolites of Cyanobacteria and Drug Development

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Book cover Extremophilic Cyanobacteria For Novel Drug Development

Part of the book series: SpringerBriefs in Pharmaceutical Science & Drug Development ((BRIEFSPSDD))

Abstract

The bioactive metabolites produced by cyanobacteria are either a peptide or macrolide structure, or a combination of both types. The peptide class is produced by two types of biosynthetic pathways: the giant multidomain enzymes, the nonribosomal peptide synthetases (NRPS) or by ribosomal synthesis and subsequent posttranslational modification and processing. The major trait of cyanobacterial pathways is their hybrid character, i.e., the frequent mixture of NRPS and polyketide synthases (PKS) modules. We discussed the important metabolites of cyanobacteria and their biosynthetic metabolic pathways. Various recent approaches in extraction of novel secondary metabolites from cyanobacteria are discussed with novel biosynthetic gene clusters found in them.

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Authors and Affiliations

  1. School of Pharmacy, University of Mississippi, Oxford, MS, USA

    Sikha Mandal & Jnanendra Rath

  2. Department of Botany Institute of Science, Visva Bharati (A Central University), 731235, Santiniketan, West Bengal, India

    Jnanendra Rath

  3. Research Associate Department of Botany Institute of Science, Visva Bharati (A Central University), 731235, Santiniketan, West Bengal, India

    Sikha Mandal

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Mandal, S., Rath, J. (2015). Secondary Metabolites of Cyanobacteria and Drug Development. In: Extremophilic Cyanobacteria For Novel Drug Development. SpringerBriefs in Pharmaceutical Science & Drug Development. Springer, Cham. https://doi.org/10.1007/978-3-319-12009-6_2

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