GTPases pp 15-19 | Cite as

Identification and Classification of Rho GTPases in Plants

  • Girdhar K. Pandey
  • Manisha Sharma
  • Amita Pandey
  • Thiruvenkadam Shanmugam
Part of the SpringerBriefs in Plant Science book series (BRIEFSPLANT)


Small GTPases have emerged as a key molecular switch for the fine modulation of many plant-specific signaling pathways and their related functions. Some novel plant-specific GTPases have evolved with the functional innovation of already conserved GTPase together with the birth of new members that has equipped plant kingdom with unique functional capability. Plant small GTPase superfamily is divided into four families: Rho, Rab, Arf, and Ran. Plant Rhos are referred to as ROP (for Rho of plants), RAC (for the sequence similarity they share with animal Racs, a Rho subfamily). The Rab, Arf, and Ran families are widely conserved across eukaryotes and they participate in characteristic eukaryotic cellular processes. Moreover, Arf, Rab, and Ran appear to play a role in fundamental cellular responses; they are not usually considered as signaling proteins that transmit extracellular signals.


G proteins Small GTPases Signal transduction ROP proteins Oryza sativa Arabidopsis thaliana 


  1. 1.
    Pandey S, Assmann SM. The Arabidopsis putative G protein-coupled receptor GCR1 interacts with the G protein alpha subunit GPA1 and regulates abscisic acid signaling. Plant Cell. 2004;16(6):1616–32.PubMedCentralPubMedCrossRefGoogle Scholar
  2. 2.
    Zheng ZL, Yang Z. The Rop GTPase: an emerging signaling switch in plants. Plant Mol Biol. 2000;44(1):1–9.PubMedCrossRefGoogle Scholar
  3. 3.
    Moshkov IE, Novikova GV. Superfamily of plant monomeric GTP-binding proteins: Rab proteins are the regulators of vesicles trafficking and plant responses to stresses. Russ J Plant Physiol. 2011;55(1):119–29.CrossRefGoogle Scholar
  4. 4.
    Yang Z. Small GTPases: versatile signaling switches in plants. Plant Cell. 2002;14(Suppl):S375–88.PubMedCentralPubMedGoogle Scholar
  5. 5.
    Vernoud V, Horton AC, Yang Z, Nielsen E. Analysis of the small GTPase gene superfamily of Arabidopsis. Plant Physiol. 2003;131(3):1191–208.PubMedCentralPubMedCrossRefGoogle Scholar
  6. 6.
    Jiang SY, Ramachandran S. Comparative and evolutionary analysis of genes encoding small GTPases and their activating proteins in eukaryotic genomes. Physiol Genomics. 2006;24(3):235–51.PubMedCrossRefGoogle Scholar

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© The Author(s) 2015

Authors and Affiliations

  • Girdhar K. Pandey
    • 1
  • Manisha Sharma
    • 1
  • Amita Pandey
    • 1
  • Thiruvenkadam Shanmugam
    • 2
  1. 1.Department of Plant Molecular BiologyDelhi University South CampusNew DelhiIndia
  2. 2.Division of Biosciences and BioinformaticsMyongji UniversityKyunggi-doRepublic of South Korea

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