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Experimental Diet Models in the Investigation of Obesity

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Rodent Model as Tools in Ethical Biomedical Research

Abstract

Several experimental models of dietary manipulation have been created for the purpose of investigating chronic-degenerative diseases. In general, such models allow for the assessment of the qualitative and quantitative alterations of nutrients and substances contained in a food regimen. Recent studies have made use of alternative forms of dietary manipulation that have resulted in the experimental development of diseases such as diabetes, dyslipidemia, and obesity (Duarte et al. 2003; Estadella et al. 2004; Manzoni et al. 2005; Cheik 2005; Guerra 2005).

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References

  • Abd El-Gawad IA, El-Sayed EM, Hafez SA, El-Zeini HM, Saleh FA. The hypocholesterolemic effect of milk yogurt and soy-yogurt containing bifidobacteria in rats fed on a cholesterol-enriched diet. Int Dairy J. 2005;15:37–44.

    Article  CAS  Google Scholar 

  • Brooks SP, Lampi BJ. Effect of dietary fat on whole body fat acid synthesis in weanling rats. J Nutr Biochem. 1999;10:291–8.

    Article  CAS  PubMed  Google Scholar 

  • Cheik NC. Effects of physical training associated to fermented soy yogurt on the dislipidemia and obesity control in adult male rats feed to normocaloric and hypercholesterolemic diet. Master Thesis. PPG-CF/ UFSCar; 2002.

    Google Scholar 

  • Cheik NC. Effects of the different nutritional interventions and exercise on hormonal regulation of food ingestion and the lipid metabolism in rats. Doctor Thesis. PPG-CF/ UFSCar; 2005.

    Google Scholar 

  • Chen JR, Chiou SF, Suetsuna K, Yang HY, Yang SC. Lipid metabolism in hipercholesterolemic rats affected by feeding cholesterol-free diets containing different amounts of non-dialyzed soybean protein fraction. Nutrition. 2003;19:676–80.

    Article  CAS  PubMed  Google Scholar 

  • Duarte FO. Metabolic adaptations of the two moderate swimming training, continuous and intermittent, in rats feed normocaloric or hypercholesterolemic diet. Master Thesis. UFSCar/PPGCF; 2001, p. 120.

    Google Scholar 

  • Duarte FO, Sene MO, Oishi JC, Bidinotto P, Perez SEA, Moraes G, et al. Weekend exercise promote dislipidemia control in adult male rats feed with high fat diet. Braz J Physiotheraphy. 2003;7:229–35.

    Google Scholar 

  • Duarte FO, Sene-Fiorese M, Zambon L, Botaro R, Freitas LF, Catelli DS, et al. Effects of food restriction on adiposity in rats with exogenous obesity. V international congress on physical education and human motricity. Motriz-J Phys Educ—UNESP. 2005;11:S62.

    Google Scholar 

  • Duarte ACGO, Fonseca DF, Manzoni MSJ, Soave CF, Sene-Fiorese M, Dâmaso AR, et al. Hiperlipidic palatable diet promote obesity, but not change secretory capacity of insulin in rats. J Nutr. 2006;19:230–8.

    Google Scholar 

  • Duelli R, Maurer MH, Staudt R, Heiland S, Duembgen L, Kuschinsky W. Increase cerebral glucose utilization and decreased glucose transporter Glut 1 during chronic hyperglycemia in rat brain. Brain Res. 2000;858:338–47.

    Article  CAS  PubMed  Google Scholar 

  • Estadella D. Effects of cafeteria diet and the alternated diet cycles on lipid metabolism in sedentary and exercised rats. São Paulo, Master Thesis—Universidade Federal de São Paulo; 2001, p. 81.

    Google Scholar 

  • Estadella D, Oyama LM, Dâmaso AR, Ribeiro EB, Oller do Nascimento CM. Effect of palatable hyperlipidic diet on lipid metabolism of sedentary and exercised rats. Nutrition. 2004;20:218–24.

    Article  CAS  PubMed  Google Scholar 

  • Feoli AM, Roehrig C, Rotta LN, Kruger AH, Souza KB, Kessler AM, et al. Serum and liver lipids in rats and chicks fed with diets containing different oils. Nutrition. 2003;19:789–93.

    Article  CAS  PubMed  Google Scholar 

  • Frayn KN. Adipose tissue as a buffer for daily lipid flux. DiIabetologia. 2002;45:1201–10.

    Article  CAS  Google Scholar 

  • Gaíva MH, Couto RC, Oyama LM, Couto GE, Silveira VL, Ribeiro EB, et al. Polynsaturated fatty acid-rich diets: effect on adipose tissue metabolism in rats. Br J Nutr. 2001;86:371–7.

    Article  PubMed  Google Scholar 

  • Giannini SD. Aterosclerose and dislipidemia. Clinical & therapeutic: practical fundament. Ed. BG Editora e Produções Culturais Ltda; 1998. pp. 1–158.

    Google Scholar 

  • Guerra RLF. Effects of continuous moderate exercise (5 or 2 days/week) on lipid metabolism and adipocyte area in adult normocaloric and hypercholesterolemic rats. São Carlos, Doctor Thesis—Universidade Federal de São Carlos; 2005, p. 92.

    Google Scholar 

  • Islam KK, Knight BL, Frayn KN, Patel DD, Gibbons GF. Deficiency of PPAR-gama disturbs the response of lipogenic flux and of lipogenic and cholesterogenic gene expression to dietary cholesterol in mouse white adipose tissue. Biochem Biophys Acta. 2005;1734:259–68.

    CAS  PubMed  Google Scholar 

  • Kopchick JJ, Andry JM. Growth hormone (GH), GH receptor, and signal transduction. Mol Genet Metab. 2000;71:293–314.

    Article  CAS  PubMed  Google Scholar 

  • Krause BR, Hartman AD. Adipose tissue and cholesterol metabolism. J Lipid Res. 1984;25:97–110.

    CAS  PubMed  Google Scholar 

  • Kretschemer BD, Schelling P, Beier N, Liebscher C, Treutel S, Kruger N, et al. Modulatory role of food, feeding regime and physical exercise on body weight and insulin resistance. Life Sci. 2005;76:1553–73.

    Article  Google Scholar 

  • Le Lay S, Krief S, Farnier C, Lefrère I, Le Liepvre X, Bazin R, et al. Cholesterol, a cell size-dependent signal that regulates glucose metabolism and gene expression in adipocytes. J Biol Chem. 2001;276:16904–10.

    Article  PubMed  Google Scholar 

  • Leonhardt M, Langhans W. Fat acid oxidation and control of food intake. Physiol Behav. 2004;83:645–51.

    Article  CAS  PubMed  Google Scholar 

  • Manzoni MSJ, Rossi EA, Carlos IZ, Vendramini RC, Duarte ACGO, Dâmaso AR. The fermented soy product supplemented with isoflavones affected fat depots in juvenile rats. Nutrition. 2005;21:1018–24.

    Article  CAS  PubMed  Google Scholar 

  • Matsudo V, Matsudo S, Andrade D, Araújo T, Andrade E, Oliveira LC, et al. Promotion of physical activity in developing country: the Agita São Paulo experience. Public Health Nutr. 2002;5:253–61.

    Article  PubMed  Google Scholar 

  • Ranier G, Gaudreau P, Hajjad H, Deslauriers N, Houde-Nadeau M, Brazeau P. Decreased pituitary growth hormone response to growth hormone-releasing factor in cafeteria-fed rats: dietary and obesity effects. Neuroendocrinology. 1990;52:284–90.

    Article  Google Scholar 

  • Rossi EA. Development and biological evaluation of the hypercholesterolemic potentital of the one new probiotic soy product Araraquara. Brasil: Universidade Estadual Paulista “Júlio de Mesquita Filho”, Thesis of the Livre Docência; 2000, p. 150.

    Google Scholar 

  • Rossi EA, Vendramini RC, Carlos IZ, de Oliveira MG, de Valdez GF. Effects of a novel fermented soy product on the serum lipids of hypercholesterolemic rabbits. Braz J Cardiol. 2000;74:213–6.

    Google Scholar 

  • Sene-Fiorese M, Duarte FO, Zambon L, Botaro R, Freitas LF, Catelli DS, et al. Effects of continuous and fractioned exercise on adiposity in rats. V international congress on physical education and human motricity. Motriz-J Phys Educ—UNESP. 2005;11:S72.

    Google Scholar 

  • Westerterp-Platenga MS. Fat intake and energy-balance effects. Physiol Behav. 2004;83:579–85.

    Article  Google Scholar 

  • Zhou X, De Schepper J, De Craemer D, Delhase M, Gys G, Smitz J, et al. Pituitary growth hormone release and gene expression in cafeteria-diet-induce obese rats. J Endrocrinol. 1998;59:165–72.

    Article  Google Scholar 

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Correspondence to Ana R. Dâmaso .

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Dâmaso, A.R. et al. (2016). Experimental Diet Models in the Investigation of Obesity. In: Andersen, M., Tufik, S. (eds) Rodent Model as Tools in Ethical Biomedical Research. Springer, Cham. https://doi.org/10.1007/978-3-319-11578-8_28

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