Abstract
A DNA Microarray or a Gene Chip comprises of a collection of microscopic spots where each spot is a DNA sequence probe representing a single gene. The DNA sequences representing at a specific location are arrayed on a solid surface and attached to a chemically suitable matrix through covalent bonds. DNA microarrays are often used for expression profiling and rely on the strength of DNA-DNA hybridization and DNA-RNA hybridization to detect and measure gene expression levels.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Liu, D., Sartor, M.A., Nader, G.A., Pistilli, E.E., Tanton, L., Lilly, C., Gutmann, L., IglayReger, H.B., Visich, P.S., Hoffman, E.P., Gordon, P.M.: Microarray analysis reveals novel features of the muscle aging process in men and women. J. Gerontol. A. Biol. Sci. Med. Sci. 68(9), 1035–1044 (2013)
Faith, J.J., Driscoll, M.E., Fusaro, V.A., Cosgrove, E.J., Hayete, B., Juhn, F.S., Schneider, S.J., Gardner, T.S.: Many microbe microarrays database: uniformly normalized affymetrix compendia with structured experimental metadata. Nucleic Acids Res. 36(Database issue), D866–D870 (2008)
Bellazzi, R., Zupan, B.: Towards knowledge-based gene expression data mining. J. Biomed. Inform. 40(6), 787–802 (2007)
Barrett, T., Edgar, R.: Mining microarray data at ncbi’s gene expression omnibus (geo)*. Methods Mol. Biol. 338, 175–190 (2006)
Zhong, S., Li, C., Wong, W.H.: Chipinfo: Software for extracting gene annotation and gene ontology information for microarray analysis. Nucleic Acids Res. 31(13), 3483–3486 (2003)
Tamames, J., Clark, D., Herrero, J., Dopazo, J., Blaschke, C., Fernández, J.M., Oliveros, J.C., Valencia, A.: Bioinformatics methods for the analysis of expression arrays: data clustering and information extraction. J. Biotechnol. 98(2-3), 269–283 (2002)
Edgar, R., Domrachev, M., Lash, A.E.: Gene expression omnibus: Ncbi gene expression and hybridization array data repository. Nucleic Acids Res. 30(1), 207–210 (2002)
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2015 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Singh, G.B. (2015). Microarrays. In: Fundamentals of Bioinformatics and Computational Biology. Modeling and Optimization in Science and Technologies, vol 6. Springer, Cham. https://doi.org/10.1007/978-3-319-11403-3_17
Download citation
DOI: https://doi.org/10.1007/978-3-319-11403-3_17
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-11402-6
Online ISBN: 978-3-319-11403-3
eBook Packages: EngineeringEngineering (R0)