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Targeted Drug Delivery : Concepts and Design pp 501–541Cite as

Polymeric Micelles in Targeted Drug Delivery

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Part of the book series: Advances in Delivery Science and Technology ((ADST))

Abstract

One of the most widely studied subjects in nanoscience technology is the creation of supramolecular architectures with well-defined structures and functionalities. These supramolecular structures are generated as a result of self-assembly of amphiphilic block polymers. Self-assembly of block polymers via hydrophobic and hydrophilic effects, electrostatic interactions, hydrogen bonding, and metal complexation has shown tremendous potential for creating such supramolecular structures with a wide array of applications. Polymeric micelles have gathered considerable attention in the field of drug and gene delivery due to their excellent biocompatibility, low toxicity, enhanced blood circulation time, and ability to solubilize a large number of drugs in their micellar core.

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Abbreviations

AFM:

Atomic force microscopy

ATRA:

All-trans retinoic acid

AUC:

Area under the curve

CMC:

Critical micellar concentration

CMT:

Critical micellization temperature

CPT:

Camptothecin

CsA:

Cyclosporine A

DNA:

Deoxy ribonucleic acid

DOX:

Doxorubicin

DSPE:

Distearoyl phosphatidyl ethanolamine

EPR:

Enhanced permeability and retention

F-5-CADA:

Fluorescein-5-carbonyl azide diacetate

FA:

Folic acid

Gd:

Gadolinium

HEMAm:

N-(2-hydroxyethyl) methacrylamide

HLB:

Hydrophilic–lipophilic balance

LCST:

Low critical solution temperature

MHC:

Minimal hydrotrope concentration

MRI:

Magnetic resonance imaging

PAsp:

Poly(aspartic acid)

PBLA:

Poly(benzyl-l-aspartate)

PCL:

Poly(e-caprolactone)

PDLLA:

PEG-b-poly(d,l-lactic acid)

PEG:

Poly(ethylene glycol)

PEO:

Polyethylene oxide

PET:

Positron emission tomography

P-gp:

P-glycoprotein

PICMs:

Polyion complex micelles

PM:

Polymeric micelle

PMMA:

Poly(methacrylate)

PPO:

Poly(propylene oxide)

PTX:

Paclitaxel

PVA:

Poly(vinyl alcohol)

RNA:

Ribonucleic acid

RT:

Room temperature

SEM:

Scanning electron microscopy

TEM:

Transmission electron microscopy

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  1. Rayasa S. Ramachandra Murthy

    Present address: , 103, Sumukha Green Ville, Sarvabhauma Nagara, Bilekahalli, Banner ghatta Road, IIMB Post office, Bangalore, 560076, India

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  1. Faculty of Technology & Engineering, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India

    Rayasa S. Ramachandra Murthy

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  1. Rayasa S. Ramachandra Murthy
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Correspondence to Rayasa S. Ramachandra Murthy .

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  1. Institute of Chemical Technology, Department of Pharmaceutical Sciences and Technology, Mumbai, India

    Padma V. Devarajan

  2. National Institute of Pharmaceutical Education and Research (NIPER), Centre for Pharmaceutical Nanotechnology, Department of Pharmaceutics, Mohali, Punjab, India

    Sanyog Jain

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Murthy, R.S.R. (2015). Polymeric Micelles in Targeted Drug Delivery. In: Devarajan, P., Jain, S. (eds) Targeted Drug Delivery : Concepts and Design. Advances in Delivery Science and Technology. Springer, Cham. https://doi.org/10.1007/978-3-319-11355-5_16

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