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Biochemical Roles of Eukaryotic Cell Surface Macromolecules pp 61–78Cite as

Membrane Rafts in the Erythrocyte Membrane: A Novel Role of MPP1p55

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 842))

Abstract

Eukaryotic cell membranes are organized into functional lipid and protein domains, the most widely studied being membrane rafts. They are enriched in sphingolipids and cholesterol and contain several types of membrane proteins such as stomatin and flotillins, which are their “permanent” residents, along with several others, such as receptors, including growth factor receptors.

Membrane rafts in the mature erythrocyte are not the remnants from erythroid precursor cell(s), but are real and dynamic domains functioning within the membrane, helping to fulfil physiological roles, of which only a few of them are just now being recognized.

The important question is the presence and role of the MPP1 protein in these domains in erythroid cells. It was well known that this was a major palmitoylation target in erythrocytes. Here we review data indicating that (palmitoylated) MPP1 functions as an organizer of membrane rafts in erythroid cells. This conclusion is strengthened by the fact that a lack of MPP1 palmitoylation, resulting from an absence of DHHC17, the only erythroid palmitoyltransferase, leads to the unique pathology of human organism.

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Abbreviations

a ZO1:

A mammalian zonula occludens protein

DlgA:

A Drosophila disc large tumor suppressor

DRM:

Detergent resistant membrane

FLIM Fluorescence  lifetime imaging L27:

Lin-2 and Lin-7 receptor targeting proteins

ld:

Liquid disordered

lo:

Liquid ordered

MAGUK:

Membrane associated guanylate kinase

MPP1:

Membrane palmitoylated protein-1

PC:

Phosphatidylcholine

PDZ PSD:

Post synaptic density protein

PE:

Phosphatidylethanolamine

PS:

Phosphatidylserine

SH3:

Src homology 3 domain

SM:

Sphingomyelin

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Authors and Affiliations

  1. Laboratory of Cytobiochemistry, Faculty of Biotechnology, University of Wrocław, ul. F. Joliot-Curie 14a, 50383, Wrocław, Poland

    Aleksander F. Sikorski, Joanna Podkalicka & Agnieszka Biernatowska

  2. BioPharm Enterprises Limited, Tanyfron 65 Gwaun Afan Cwmafan, Port Talbot, Neath Port Talbot, Wales, SA12 9EJ, UK

    Walis Jones

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  1. Aleksander F. Sikorski
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  2. Joanna Podkalicka
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  3. Walis Jones
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  4. Agnieszka Biernatowska
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Correspondence to Aleksander F. Sikorski .

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  1. Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, Kolkata, India

    Abhijit Chakrabarti

  2. Molecular Biophysics Unit, Indian Institute of Science, Bengaluru, India

    Avadhesha Surolia

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Sikorski, A.F., Podkalicka, J., Jones, W., Biernatowska, A. (2015). Membrane Rafts in the Erythrocyte Membrane: A Novel Role of MPP1p55. In: Chakrabarti, A., Surolia, A. (eds) Biochemical Roles of Eukaryotic Cell Surface Macromolecules. Advances in Experimental Medicine and Biology, vol 842. Springer, Cham. https://doi.org/10.1007/978-3-319-11280-0_5

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