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Atlas-Guided Global Tractography: Imposing a Prior on the Local Track Orientation

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Computational Diffusion MRI

Part of the book series: Mathematics and Visualization ((MATHVISUAL))

Abstract

Since its introduction over a decade ago, diffusion tractography has come a long way from local, deterministic methods, over probabilistic approaches, towards global tractography. Yet, the development of tractography methods has been largely focused on single subject data, and very little on cross-population analysis and inter-subject variability. In this work, we extend global tractography with a prior on the local track orientation distribution (TOD), derived from 20 normal subjects. The proposed method is evaluated in five independent subjects. Results show that adding such prior regularizes the reconstructed track distribution, although registration errors can induce local artefacts. We conclude that atlas-guided global tractography can improve the fibre reconstruction and ultimately detect and quantify inter-subject differences in tractography.

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Acknowledgements

D. Christiaens is supported by a Ph.D. grant of the Agency for Innovation by Science and Technology (IWT). Data were provided by the Human Connectome Project, WU-Minn Consortium (Principal Investigators: David Van Essen and Kamil Ugurbil; 1U54MH091657) funded by the 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research; and by the McDonnell Center for Systems Neuroscience at Washington University.

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Authors and Affiliations

  1. Department of Electrical Engineering, Medical Image Computing, KU Leuven, Leuven, Belgium

    Daan Christiaens, Thijs Dhollander, Frederik Maes & Paul Suetens

  2. Medical Imaging Research Center, University Hospitals Leuven, Leuven, Belgium

    Daan Christiaens, Thijs Dhollander, Frederik Maes, Stefan Sunaert & Paul Suetens

  3. Medical IT Department, iMinds, Ghent, Belgium

    Daan Christiaens, Thijs Dhollander, Frederik Maes & Paul Suetens

  4. Department of Radiology, Medical Physics, University of Freiburg Medical Center, Freiburg, Germany

    Marco Reisert

  5. Department of Imaging & Pathology, Translational MRI, KU Leuven, Leuven, Belgium

    Stefan Sunaert

Authors
  1. Daan Christiaens
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  2. Marco Reisert
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  3. Thijs Dhollander
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  4. Frederik Maes
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  5. Stefan Sunaert
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  6. Paul Suetens
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Corresponding author

Correspondence to Daan Christiaens .

Editor information

Editors and Affiliations

  1. Harvard Medical School Brigham and Women's Hospital, Boston, Massachusetts, USA

    Lauren O'Donnell

  2. Dept. of Computer Science, University College London Dept of Computer Science, London, United Kingdom

    Gemma Nedjati-Gilani

  3. Harvard Medical School Brigham and Women's Hospital, Boston, Massachusetts, USA

    Yogesh Rathi

  4. University Medical Center Freiburg Department of Radiology, Freiburg, Germany

    Marco Reisert

  5. Queen Square Multiple Sclerosis Centre, UCL Institute of Neurology, Queen Square House, Queen Square, London, United Kingdom

    Torben Schneider

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© 2014 Springer International Publishing Switzerland

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Christiaens, D., Reisert, M., Dhollander, T., Maes, F., Sunaert, S., Suetens, P. (2014). Atlas-Guided Global Tractography: Imposing a Prior on the Local Track Orientation. In: O'Donnell, L., Nedjati-Gilani, G., Rathi, Y., Reisert, M., Schneider, T. (eds) Computational Diffusion MRI. Mathematics and Visualization. Springer, Cham. https://doi.org/10.1007/978-3-319-11182-7_11

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