Approach to the Patient with Lipid Disorders
Disorders of lipid metabolism have and continue to be a focal point of research and treatment due to their well-known connection with cardiovascular disease (CVD) and atherosclerosis. Hypertriglyceridemia, in contrast to elevated low density lipoprotein (LDL-C) levels and low levels of high density lipoprotein (HDL), has had a more tenuous relationship as a true independent risk of future CVD events. Although the association between elevated triglyceride (TG) levels and CAD is one of long standing the absolute contribution as a CVD risk factor has been modest or confounded by other lipoprotein parameters. In this chapter, we present a pragmatic approach to the patient at risk of cardiovascular disease, distinguishing lipid disorders that confer an increased CVD risk.
KeywordsCholesteryl ester transfer protein (CETP) Coronary artery disease (CAD) High density lipoprotein (HDL) Intermediate density lipoproteins (IDL) Lipoprotein lipase (LPL) Low density lipoprotein (LDL) Nuclear magnetic resonance (NMR) Triglycerides (TG) Verticle auto profile (VAP) Very low density lipoprotein (VLDL)
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