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Is Low HDL Cholesterol a Marker or a Mediator of Cardiovascular Disease?

  • Hussein YassineEmail author
Chapter
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Abstract

In this chapter, we review HDL’s role in reverse cholesterol transport and point out to evidence supporting that HDL acts as a shuttle to transport cholesterol to other lipoproteins, with important roles that are not restricted to the cardiovascular system. We then discuss the atheroprotective roles of HDL in light of the several recent randomized clinical trials that were aimed at raising HDL cholesterol but failed to improve cardiovascular outcomes, and conclude that low HDL cholesterol is a marker, and not a mediator of cardiovascular disease.

Keywords

Cholesterol Familial hypercholesterolemia LDL HDL VLDL FH LDLR Cholesterol disease Increased cholesterol levels Lipoprotein Cardiovascular disease Gene Clinical signs Lipid 

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Medicine DepartmentUniversity of Southern CaliforniaLos AngelesUSA

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