Abstract
MR enterography has become one of the main imaging tools for evaluation of inflammatory bowel disease. This cross-sectional imaging modality allows assessment of the entire small bowel and of the extraintestinal complications in patients with Crohn’s disease. MR enterography has the advantage of being a non-ionizing radiation imaging tool compared to small bowel follow through, CT enterography and enteroclysis. It allows evaluation of bowel wall thickening and edema, bowel wall enhancement and ulcerations, which all indicate disease activity. Although endoscopy with biopsy remains the gold standard for assessing mucosal disease activity, MR enterography provides additional information about the entire bowel wall and depicts extraintestinal findings such as fistulas and abscesses. MR enterography is a suitable tool for documenting the presence of disease and for evaluating the response to therapy. It has potential to become the standard tool for serial assessment of bowel damage over time. Recent quantitative imaging techniques, such as diffusion-weighted imaging, motility imaging and magnetization transfer imaging are promising and could improve the assessment of disease activity, severity and response to therapy.
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References
Messaris E, Chandolias N, Grand D, et al. Role of magnetic resonance enterography in the management of Crohn disease. Arch Surg. 2010;145(5):471–5.
Masselli G, Gualdi G. CT and MR enterography in evaluating small bowel diseases: when to use which modality? Abdom Imaging. 2013;38:249–59.
Towbin AJ, Sullivan J, Denson LA, et al. CT and MR enterography in children and adolescents with inflammatory bowel disease. Radiographics. 2013;33:1843–60.
Buisson A, Joubert A, Montoriol PF, et al. Diffusion-weighted magnetic resonance imaging for detecting and assessing ileal inflammation in Crohn’s disease. Aliment Pharmacol Ther. 2013;37:537–45.
Oussalah A, Laurent V, Bruot O, et al. Diffusion-weighted magnetic resonance without bowel preparation for detecting colonic inflammation in inflammatory bowel disease. Gut. 2010;59:1056–65.
Pazahr S, Blume I, Frei P, et al. Magnetization transfer for the assessment of bowel fibrosis in patients with Crohn’s disease: initial experience. MAGMA. 2013;26:291–301.
Yacoub JH, Oto A. New magnetic resonance imaging modalities for Crohn disease. Magn Reson Imaging Clin N Am. 2014;22(1):35–50.
Makanyanga JC, Taylor SA. Current and future role of MR enterography in the management of Crohn disease. AJR Am J Roentgenol. 2013;201:56–64.
Yacoub JH, Obara P, Oto A. Evolving role of MRI in Crohn’s disease. J Magn Reson Imaging. 2013;37:1277–89.
Froehlich JM, Waldherr C, Stoupis C, et al. MR motility imaging in Crohn’s disease improves lesion detection compared with standard MR imaging. Eur Radiol. 2010;20:1945–51.
Giusti S, Faggioni L, Neri E, et al. Dynamic MRI of the small bowel: usefulness of quantitative contrast-enhancement parameters and time-signal intensity curves for differentiating between active and inactive Crohn’s disease. Abdom Imaging. 2010;35:646–53.
Menys A, Atkinson D, Odille F, et al. Quantified terminal ileal motility during MR enterography as a potential biomarker of Crohn’s disease activity: a preliminary study. Eur Radiol. 2012;22(11):2494–501.
Cullmann JL, Bickelhaupt S, Froehlich M, et al. MR imaging in Crohn’s disease: correlation of MR motility measurement with histopathology in the terminal ileum. Neurogastroenterol Motil 2013;25:749–e577
Ziech ML, Lavini C, Bipat S, et al. Dynamic contrast-enhanced MRI in determining disease activity in perianal fistulizing Crohn disease: a pilot study. AJR Am J Roentgenol. 2013;200:W170–7.
Lucendo AJ, Guagnozzi D. Small bowel video capsule endoscopy in Crohn’s disease: What have we learned in the last ten years? World J Gastrointest Endosc. 2011;3(2):23–9.
Castiglione F, Maintenti PP, De Palma DG, et al. Noninvasive diagnosis of small bowel Crohn’s disease: direct comparison of bowel sonography and magnetic resonance enterography. Inflamm Bowel Dis. 2013;19(5):991–8.
Shellock FG, Crues JV. MR procedures: biologic effects, safety, and patient care. Radiology. 2004;232:635–52.
Tolan DJ, Greenhalgh R, Zealley IA, et al. MR enterography manifestations of small bowel Crohn disease. Radiographics. 2010;30:367–84.
Santillan C. MR imaging techniques of the bowel. Magn Reson Imaging Clin N Am. 2014;22:1–11.
Ajaj W, Goehde SC, Schneemann H, et al. Oral contrast agents for small bowel MRI: comparison of different additives to optimize bowel distension. Eur Radiol. 2004;14:458–64.
Kuehle CA, Ajaj W, Ladd SC, et al. Hydro-MRI of the small bowel: effect of contrast volume, timing of contrast administration, and data acquisition on bowel distention. AJR Am J Roentgenol. 2006;187:W375–85.
Negaard A, Paulsen V, Sandvik L, et al. A prospective randomized comparison between two MRI studies of the small bowel in Crohn’s disease, the oral contrast method and MR enteroclysis. Eur Radiol. 2007;17:2294–301.
Cronin CG, Lohan DG, Mhuircheartaigh JN, et al. MRI small-bowel follow-through: prone versus supine patient positioning for best small-bowel distention and lesion detection. AJR Am J Roentgenol. 2008;191(2):502–6.
Heverhagen JT, Krombach GA and Gizewski E, Application of Extracellular Gadolinium-based MRI contrast agents and the risk of nephrogenic systemic fibrosis. Rofo 2014 186(7):661–9
ESUR guidelines on Contrast Media version 8.0. See http://www.esur.org/guidelines/
Al-Hawary MM, Zimmermann EM, Hussain HK. MR imaging of the small bowel in Crohn disease. Magn Reson Imaging Clin N Am. 2014;22:13–22.
Pupillo VA, Cesare ED, Frieri G, et al. Assessment of inflammatory activity in Crohn’s disease by means of dynamic contrast-enhanced MRI. Radiol Med. 2007;112:798–809.
Gourtsoyianni S, Papanikolaou N, Amanakis E, et al. Crohn’s disease lymphadenopathy: MR imaging findings. Eur J Radiol. 2009;69:425–8.
Ziech ML, Lavini C, Caan MW, et al. Dynamic contrast-enhanced MRI in patients with luminal Crohn’s disease. Eur J Radiol. 2012;81:3019–27.
Oto A, Fan X, Mustafi D, et al. Quantitative analysis of dynamic contrast enhanced MRI for assessment of bowel inflammation in Crohn’s disease: Pilot Study 1. Acad Radiol. 2009;16(10):1223–30.
Taylor SA, Punwani S, Rodriguez-Justo M, et al. Mural Crohn Disease: correlation of dynamic contrast-enhanced MR imaging findings with angiogenesis and inflammation at histologic examination-Pilot Study 1. Radiology. 2009;251:369–79.
Adler J, Swanson SD, Schmiedlin-Ren P, et al. Magnetization Transfer helps detect intestinal fibrosis in an animal model of Crohn disease. Radiology. 2011;259:127–35.
Breynaert C, Dresselaers T, Perrier C, et al. Unique gene expression and MR T2 relaxometry patterns define chronic Murine Dextran Sodium Sulphate Colitis as a model for connective tissue changes in human Crohn’s disease. PLoS One. 2013;8(7):e68876.
Breynaert C, Dresselaers T, Peeters R, et al. MRI T2 relaxometry to image fibrosis in patients with Crohn’s disease. ECCO 2014 P187
Girometti R, Zuiani C, Toso F, et al. MRI scoring system including dynamic motility evaluation in assessing the activity of Crohn’s disease of the terminal ileum. Acad Radiol. 2008;15:153–64.
Rimola J, Rodriguez S, Garcia-Bosch O, et al. Magnetic resonance for assessment of disease activity and severity in ileocolonic Crohn’s disease. Gut. 2009;58:1113–20.
Rimola J, Ordàs I, Rodriguez S, et al. Magnetic Resonance Imaging for evaluation of Crohn’s disease: validation of parameters of severity and quantitative index of activity. Inflamm Bowel Dis. 2011;17(8):1759–68.
Steward M, Punwani S, Proctor I, et al. Non-perforating small bowel Crohn’s disease assessed by MRI enterography: derivation and histopathological validation of an MR-based activity index. Eur J Radiol. 2012;81:2080–8.
Horsthuis K, Bipat S, Stokkers P, et al. Magnetic resonance imaging for evaluation of disease activity in Crohn’s disease: a systematic review. Eur Radiol. 2009;19:1450–60.
Hafeez R, Punwani S, Boulos P, et al. Diagnostic and therapeutic impact of MR enterography in Crohn’s disease. Clin Radiol 2011;66:1148–1158.
Ha CY, Kumar N, Raptis CA, et al. Magnetic resonance enterography: safe and effective imaging for stricturing Crohn’s disease. Dig Dis Sci 2011;56:2906–2913.
Samuel S, Bruining DH, Loftus EV, et al. Endoscopic skipping of the distal terminal ileum in Crohn’s disease can lead to negative results from ileocolonoscopy. Clin Gastroenterol Hepatol. 2012;10:1253–9.
Siddiki HA, Fidler JL, Fletcher JG, et al. Prospective comparison of state-of-the-art MR enterography and CT enterography in small-bowel Crohn’s disease. AJR Am J Roentgenol. 2009;193:113–21.
Madsen SM, Thomsen HS, Schlichting P, et al. Evaluation of treatment response in active Crohn’s disease by low-field magnetic resonance imaging. Abdom Imaging. 1999;24:232–9.
Van Assche GA, Herrmann KA, Louis E, et al. Effects of infliximab therapy on transmural lesions assessed by MRI enteroclysis in patients with ileal Crohn’s disease. J Crohns Colitis. 2013;7:950–7.
Tielbeek J, Löwenberg M, Bipat S, et al. Serial Magnetic Resonance Imaging for monitoring medical therapy effects in Crohn’s disease. Inflamm Bowel Dis. 2013;19:1943–50.
Ordàs I, Rimola J, Rodriguez S, et al. Accuracy of Magnetic Resonance Enterography in assessing Response to therapy and mucosal healing in patients with Crohn’s disease. Gastroenterology. 2014;146:374–82.
Pariente B, Cosnes J, Danese S, et al. Development of the Crohn’s disease digestive damage score, the Lémann score. Inflamm Bowel Dis. 2011;17:1415–22.
Panes J, Bouhnik Y, Reinisch W, et al. Imaging techniques for assessment of inflammatory bowel disease: Joint ECCO and ESGAR evidence-based consensus guidelines. J Crohns Colitis. 2013;7(7):556–85.
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Vanslembrouck, R., Vanbeckevoort, D., Chawla, T.P., Van Assche, G. (2015). Magnetic Resonance Enterography. In: Kozarek, R., Chiorean, M., Wallace, M. (eds) Endoscopy in Inflammatory Bowel Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-11077-6_5
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DOI: https://doi.org/10.1007/978-3-319-11077-6_5
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