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Diseases That Can Mimic IBD

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Endoscopy in Inflammatory Bowel Disease

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Abstract

Malfunctioning of the gastrointestinal tract can present in only a finite number of ways. Thus patients with many maladies may complain of similar abdominal pain, nausea, vomiting, distension, gassiness, diarrhea, and constipation. As described elsewhere in this volume, these could be symptoms of ulcerative colitis (UC), Crohn’s disease (CD), or indeterminate colitis. Yet there are a number of other diseases that can mimic inflammatory bowel disease (IBD). It is with this differential diagnosis that this chapter deals. In broad categories these IBD-simulators can be grouped into: “non-IBD” inflammatory, infectious, vascular, iatrogenic, motility, and other idiopathic conditions.

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References

  1. Feakins RM. British Society of Gastroenterology. Inflammatory bowel disease biopsies: updated British Society of Gastroenterology reporting guidelines. J Clin Pathol. 2013;66:1005–26.

    Article  PubMed  Google Scholar 

  2. Maeshiro T, Hokama A, Kinjo T, Fujita J. Diverticular colitis of the ascending colon preceding the onset of ulcerative colitis. BMJ Case Rep. 2014. doi:10.1136/bcr-2014-204361.

    Google Scholar 

  3. Navaneethan U, Giannella RA. Mechanisms of infectious diarrhea. Nat Clin Pract Gastroenterol Hepatol. 2008;5:637–47.

    Article  PubMed  Google Scholar 

  4. Maki DG. Coming to grips with foodborne infection: peanut butter, peppers, and nationwide salmonella outbreaks. N Engl J Med. 2009;360:949–53.

    Article  CAS  PubMed  Google Scholar 

  5. Chen J, Zhang L, Paoli GC, Shi C, Tu SI, Shi X. A real-time PCR method for the detection of Salmonella enterica from food using a target sequence identified by comparative genomic analysis. Int J Food Microbiol. 2010;137:168–74.

    Article  CAS  PubMed  Google Scholar 

  6. Gradel KO, Nielsen HL, Schonheyder HC, Ejlertsen T, Kristensen B, Nielsen H. Increased short- and long term risk of inflammatory bowel disease after Salmonella or Campylobacter gastroenteritis. Gastroenterology. 2009;137:495–501.

    Article  PubMed  Google Scholar 

  7. Centers for Disease Control and Prevention (CDC). Preliminary FoodNet data on the incidence of infection with pathogens transmitted commonly through food: appreciate 10 states, 2009. MMWR Morb Mortal Wkly Rep. 2010;59:418–22.

    Google Scholar 

  8. Sperandio B, Regnault B, Guo J, Zhang Z, Stanley Jr SL, Sansonetti PJ, et al. Virulent Shigella flexneri subverts the host innate immune response through manipulation of antimicrobial peptide gene expression. J Exp Med. 2008;205:1121–32.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  9. Prince Christopher RH, David KV, John SM, Sankarapandian V. Antibiotic therapy for Shigella dysentery. Cochrane Database Syst Rev 2010:CD006784.

    Google Scholar 

  10. Lim JY, Yoon J, Hovde CJ. A brief overview of Escherichia coli O157:H7 and its plasmid O157. J Microbiol Biotechnol. 2010;20:5–14.

    CAS  PubMed Central  PubMed  Google Scholar 

  11. Pawlowski SW, Warren CA, Guerrant R. Diagnosis and treatment of acute or persistent diarrhea. Gastroenterology. 2009;136:1874–86.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  12. Ximenez C, Cerritos R, Rojas L, Dolabella S, Moran P, Shibayama M, et al. Human amebiasis: breaking the paradigm? Int J Environ Res Public Health. 2010;7:1105–20.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  13. Natarajan M, Walk ST, Young VB, Aronoff DM. A clinical and epidemiological review of non-toxigenic Clostridium difficile. Anaerobe. 2013;22:1–5.

    Article  PubMed Central  PubMed  Google Scholar 

  14. Kim PK, Huh HC, Cohen HW, Feinberg EJ, Ahmad S, Coyle C, et al. Intracolonic vancomycin for severe Clostridium difficile colitis. Surg Infect (Larchmt). 2013;14:532–9.

    Article  Google Scholar 

  15. Kurtz M, Morgan M. Concomitant Clostridium difficile colitis and cytomegalovirus colitis in an immunocompetent elderly female. BMJ Case Rep 2012. doi: 10.1136/bcr-2012-007273

    Google Scholar 

  16. Harbrecht BG, Franklin GA, Shirley RM, Smith JW, Miller FB, Richardson JD. Statewide experience with Clostridium difficile colitis in academic and non-academic medical centers. Surg Infect (Larchmt). 2012;13:88–92.

    Article  Google Scholar 

  17. Feasey NA, Healey P, Gordon MA. Review article: the aetiology, investigation and management of diarrhea in the HIV-positive patient. Aliment Pharmacol Ther. 2011;34:587–603.

    Article  CAS  PubMed  Google Scholar 

  18. Kasapovic A, Boesecke C, Schwarze-Zander C, Anadol E, Vogel M, Hippe V, et al. Screening colonoscopy in HIV-infected patients: high rates of mucosal abnormalities in a German HIV-infected cohort. HIV Med. 2014;15:175–81.

    Article  CAS  PubMed  Google Scholar 

  19. Hamada Y, Nagata N, Honda H, Asayama N, Teruya K, Igari T, et al. Epstein-Barr virus associated colitis in an HIV-infected patient. AIDS. 2012;26:400–2.

    Article  PubMed  Google Scholar 

  20. Villalon C, Quezada F, Hartmann J, Roa JC, Urrejola G. Synchronous ileocecal and duodenal tuberculosis: case report and review of the literature. Int J Colorectal Dis. 2014;29:1027–8.

    Article  PubMed  Google Scholar 

  21. Wang ZK, Shi H, Wang SD, Liu J, Zhu WM, Yang MF, et al. Confusing untypical intestinal Behcet’s disease: Skip ulcers with severe lower gastrointestinal hemorrhage. World J Gastrointest Endosc. 2014;6:27–31.

    Article  PubMed Central  PubMed  Google Scholar 

  22. Sharath Chandra BJ, Girish TU, Thrishuli PB, Vinay HG. Primary tuberculosis of the appendix: a rare cause of a common disease. J Surg Tech Case Rep. 2013;5:32–4.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  23. Guven H, Koc B, Saglam F, Bayram IA, Adas G. Emergency right hemicolectomy for inflammatory cecal masses mimicking acute appendicitis. World J Emerg Surg. 2014;9:7.

    Article  PubMed Central  PubMed  Google Scholar 

  24. Sadot E, Telem DA, Cohen L, Arora M, Divino CM. Nonocclusive ischemic colitis: analysis of risk factors for severity. Am Surg. 2014;80:454–60.

    PubMed  Google Scholar 

  25. Johal K, Ratuapli SK, Lam-Himlin DM, Gurudu SR. Mycophenolate mofetil-induced segmental colitis mimicking ischemic colitis. Case Rep Gastroenterol. 2014;8:95–100.

    Article  PubMed Central  PubMed  Google Scholar 

  26. Lee SO, Kim SH, Jung SH, Park CW, Lee MJ, Lee JA, et al. Colonoscopy-induced ischemic colitis in patients without risk factors. World J Gastroenterol. 2014;20:3698–702.

    Article  PubMed Central  PubMed  Google Scholar 

  27. Manickam P, Jaurigue M, Batke M, Cappell MS. Recurrent ischemic colitis associated with oral contraceptive therapy. J Dig Dis. 2014;15:331–3.

    Article  PubMed  Google Scholar 

  28. Sherid M, Samo S, Husein H, Sulaiman S, Vainder JA. Pseudoephedrine-induced ischemic colitis: case report and literature review. J Dig Dis. 2014;15:276–80.

    Article  PubMed  Google Scholar 

  29. Washington C, Carmichael JC. Management of ischemic colitis. Clin Colon Rectal Surg. 2012;25:228–35.

    Article  PubMed Central  PubMed  Google Scholar 

  30. Tadros M, Majumder S, Birk JW. A review of ischemic colitis: is our clinical recognition and management adequate? Expert Rev Gastroenterol Hepatol. 2013;7:605–13.

    Article  PubMed  Google Scholar 

  31. Tonolini M. Acute nonsteroidal anti-inflammatory drug-induced colitis. J Emerg Trauma Shock. 2013;6:301–3.

    Article  PubMed Central  PubMed  Google Scholar 

  32. Tissot B, Lamy A, Perraudeau F, Manouvrier JL, Imbert Y. Acute severe colitis with recto-vaginal fistula during treatment with non-steroidal anti-inflammatory agents. Presse Med. 2002;31:1131–3.

    CAS  PubMed  Google Scholar 

  33. Mokhtare M, Valizadeh SM, Emadian O. Lower Gastrointestinal Bleeding due to Non-Steroid Anti-Inflammatory Drug-Induced Colopathy Case Report and Literature Review. Middle East J Dig Dis. 2013;5:107–11.

    PubMed Central  PubMed  Google Scholar 

  34. Pusztaszeri M, Girardin M, Hadengue A, Rubbia-Brandt L, Genevay M. Drug-induced injury in the gastrointestinal tract: a clinic-pathological review. Rev Med Suisse. 2010;6:1650–5.

    PubMed  Google Scholar 

  35. Viana FF, Chen Y, Almeida AA, Baxter HD, Cochrane AD, Smith JA. Gastrointestinal complications after cardiac surgery: 10-year experience of a single Australian centre. ANZ J Surg. 2013;83:651–6.

    Article  PubMed  Google Scholar 

  36. Yamamoto M, Sasguri S, Sato T. Assessing intraoperative blood flow in cardiovascular surgery. Surg Today. 2011;41:1467–74.

    Article  PubMed  Google Scholar 

  37. Angiletta D, Marinazzo D, Guido G, Greco L, Regina G. Spinal cord, bowel, and buttock ischemia after endovascular aneurysm repair. Ann Vasc Surg 2011;25:980.e15-9.

    Google Scholar 

  38. Maggio A, Magli A, Rancati T, Fiorino C, Valvo F, Fellin G, et al. Daily sodium butyrate enema for the prevention of radiation proctitis in prostate cancer patients undergoing radical radiation therapy: results of a multicenter randomized placebo-controlled dose-finding phase 2 study. Int J Radiat Oncol Biol Phys. 2014;89:518–24.

    Article  PubMed  Google Scholar 

  39. Hoggan BL, Cameron AL. Systematic review of hyperbaric oxygen therapy for the treatment of non-neurological soft tissue radiation-related injuries. Support Care Center. 2014;22:1715–26.

    Article  Google Scholar 

  40. Fuentes-Raspall R, Inoriza JM, Rosello-Serrano A, Aunon-Sanz C, Garcia-Martin P, Oliu-Isern G. Late rectal and bladder toxicity following radiation therapy for prostate cancer: Predictive factors and treatment results. Rep Pract Oncol Radiother. 2013;18:298–303.

    Article  PubMed Central  PubMed  Google Scholar 

  41. Karamanolis G, Psatha P, Triantafyllou K. Endoscopic treatments for chronic radiation proctitis. World J Gastrointest Endosc. 2013;5:308–12.

    Article  PubMed Central  PubMed  Google Scholar 

  42. Stojcev Z, Krokowicz L, Krokowicz P, Szczepowski M, Borycka-Kiciak K, Kiciak A, et al. Early treatment and prevention of the radiation proctitis—composite enemas containing sodium butyrate. Int J Colorectal Dis. 2013;28:1731–2.

    Article  PubMed Central  PubMed  Google Scholar 

  43. Eddi R, Depasquale JR. Radiofrequency ablation for the treatment of radiation proctitis: a case report and review of literature. Therap Adv Gastroenterol. 2013;6:69–76.

    Article  PubMed Central  PubMed  Google Scholar 

  44. Mendenhall WM, McKibben BT, Hoppe BS, Nichols RC, Henderson RH, Mendenhall NP. Management of radiation proctitis. Am J Clin Oncol 2013. doi: 10.1097/COC.0b013e318271b1aa.

  45. Chruscielewska-Kiliszek MR, Regula J, Polkowski M, Rupinskin M, Kraszewska E, Pachlewski J, et al. Sucralfate or placebo following argon plasma coagulation for chronic radiation proctitis: a randomized double blind trial. Colorectal Dis. 2013;15:e48–55.

    Article  CAS  PubMed  Google Scholar 

  46. Sahakitrungruang C, Patiwongpaisarn A, Kanjanasilp P, Malakorn S, Atittharnsakul P. A randomized controlled trial comparing colonic irrigation and oral antibiotics administration versus 4 % formalin application for treatment of hemorrhagic radiation proctitis. Dis Colon Rectum. 2012;55:1053–8.

    Article  PubMed  Google Scholar 

  47. Pironi D, Panarese A, Vendettuoli M, Pontone S, Candioli S, Manigrasso A, et al. Chronic radiation-induced proctitis: the 4 % formalin application as non-surgical treatment. Int J Colorectal Dis. 2013;28:261–6.

    Article  PubMed  Google Scholar 

  48. Bennett MJ, Feldmeier J, Hampson N, Smee R, Milross C. Hyperbaric oxygen therapy for late radiation tissue injury. Cochrane Database Syst Rev 2012 May 16;5:CD005005. Doi: 10.1002/14651858.CD005005.pub3

    Google Scholar 

  49. Evans C, Ong E, Jones OM, Cunningham C, Lindsey I. Laparoscopic ventral rectopexy is effective for solitary rectal ulcer syndrome when associated with rectal prolapse. Colorectal Dis. 2014;16:o112–6.

    Article  CAS  PubMed  Google Scholar 

  50. Zhu QC, Shen RR, Qin HL, Wang Y. Solitary rectal ulcer syndrome: clinical features, pathophysiology, diagnosis and treatment strategies. World J Gastroenterol. 2014;20:738–44.

    Article  PubMed Central  PubMed  Google Scholar 

  51. Dehghani SM, Malekpour A, Haghighat M. Solitary rectal ulcer syndrome in children: a literature review. World J Gastroenterol. 2012;18:6541–5.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  52. Coyne JD. Pseudomembranes in rectal prolapse: a report of two cases. Int J Surg Pathol. 2013;21:422–3.

    Article  PubMed  Google Scholar 

  53. Ingle SB, Patle YG, Murdeshwar HG, Hinge Ingle CR. An unusual case of solitary rectal ulcer syndrome mimicking inflammatory bowel disease and malignancy. Arab J Gastroenterol. 2012;13:102.

    Article  PubMed  Google Scholar 

  54. Abid S, Khawaja A, Bhimani SA, Ahmad Z, Hamid S, Jafri W. The clinical, endoscopic and histological spectrum of the solitary rectal ulcer syndrome: a single-center experience of 116 cases. BMC Gastroenterol. 2012;12:72.

    Article  PubMed Central  PubMed  Google Scholar 

  55. Yagnik VD. Massive rectal bleeding: rare presentation of circumferential solitary rectal ulcer syndrome. Saudi J Gastroenterol. 2011;17:298.

    Article  PubMed Central  PubMed  Google Scholar 

  56. Yen EF, Pardi DS. Review of the microscopic colitides. Curr Gastroenterol Rep. 2011;13:458–64.

    Article  PubMed  Google Scholar 

  57. Yen EF, Pardi DS. Review article: Microscopic colitis—lymphocytic, collagenous and ‘mast cell’ colitis. Aliment Pharmacol Ther. 2011;34:21–32.

    Article  CAS  PubMed  Google Scholar 

  58. Pardi DS. Miscellaneous colitides. Curr Opin Gastroenterol. 2012;28:76–81.

    Article  PubMed  Google Scholar 

  59. Yagi K, Endo S, Nakamura A, Sekine A. Clinical course of drug-induced collagenous colitis and histological changes after drug withdrawal in a Japanese case series. Eur J Gastroenterol Hepatol. 2012;24:1105–9.

    Article  PubMed  Google Scholar 

  60. Keszthelyi D, Penders J, Masclee AA, Pierik M. Is microscopic colitis a drug-induced disease? J Clin Gastroenterol. 2012;46:811–22.

    Article  CAS  PubMed  Google Scholar 

  61. Mendoza-Pinto C, Garcia-Carrasco M, Jimenez-Hernandez M, Jimenez-Hernandez C, Riebeling-Navarro C, Nava Zavala A, et al. Etiopathogenesis of Behcet’s disease. Autoimmun Rev. 2010;9:241–5.

    Article  CAS  PubMed  Google Scholar 

  62. Hatemi G, Merkel PA, Hamuryudan V, Boers M, Direskeneli H, Aydin SZ, et al. Outcome measures used in clinical trials for Behcet syndrome: a systematic review. J Rheumatol. 2014;41:599–612.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Gastroenterology, Icahn School of Medicine, The Mount Sinai Hospital, 920 Park Avenue, New York, NY, 10028, USA

    Peter Rubin MD

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  1. Peter Rubin MD
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Correspondence to Peter Rubin MD .

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Editors and Affiliations

  1. Digestive Disease Institute, Virginia Mason Medical Center, Seattle, Washington, USA

    Richard Kozarek

  2. Digestive Disease Institute, Virginia Mason Medical Center, Seattle, Washington, USA

    Michael Chiorean

  3. Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida, USA

    Michael Wallace

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Rubin, P. (2015). Diseases That Can Mimic IBD. In: Kozarek, R., Chiorean, M., Wallace, M. (eds) Endoscopy in Inflammatory Bowel Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-11077-6_10

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  • DOI: https://doi.org/10.1007/978-3-319-11077-6_10

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