Modeling of Tumour Growth Induced by Circadian Rhythm Disruption in Epithelial Tissue

  • Dmitry BratsunEmail author
  • Andrey Zakharov
  • Len Pismen
Part of the Emergence, Complexity and Computation book series (ECC, volume 14)


We propose a multiscale model of cancer tumour growth in a quasi epithelial tissue. Basic model of the epithelium growth describes the appearance of intensive movement and growth of tissue via mechanisms of division and intercalation of cells. It is assumed that the movement of cells is caused by the wave of mitogen-activated protein kinase (MAPK), which in turn activated by the chemo-mechanical signal propagating along tissue due to its local damage. It is assumed also that cancer cells can arise from local failure of a spatial synchronization of circadian rhythms. We hope that the subsequent study of the dynamic properties of the model could determine the relationship between the occurrence of the cancer cells and development of the entire tissue coordinating its evolution through the exchange of chemical and mechanical signals.


cancer modeling circadian rhythms gene regulation signaling time-delay complexity in biology 


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© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Theoretical Physics DepartmentPerm State Humanitarian Pedagogical UniversityPermRussia
  2. 2.Department of Chemical EngineeringTechnion - Israel Institute of TechnologyHaifaIsrael

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