Prospective and Opportunities of High Pressure Processing in the Food, Nutraceutical and Pharmacy Market

  • Ignacio GraciaEmail author
Part of the Food Engineering Series book series (FSES)


High pressure processing (HPP) technology is ready to be widely used for the development of new products. One of the most promising applications of HPP processing concerns food, nutraceutical and pharmacy industry, in which several processes are profitable, and HPP products are really available with proven therapeutic characteristics. In spite of the advantages about production, safety, quality, normative and marketing, the industrial implementation of HHP products is scant, and generally associated to high scale production capacities because their products are generally considered like simple substitutes for lower market niche alternatives. This chapter presets some information for researchers to be able to understand basic concepts of economy related to the industrial implementation of HHP. Based on a Business Plan procedure, several tools and strategies are presented in order to be able to determine and quantify the industrial potential of HPP. The SWOT test will be able to identify business strategies and the possibility to change the market segment. New emerging opportunities about regulations, labelling, market demands and high marketing values have to be exploited. Several methods are described for cost estimation, to determine the price curve and to quantify the project profitability in terms of financial ratios. Finally, a review about literature estimations for manufacturing costs for HPP is included, in addition to those costs corresponding to real industrial applications and available products.


Food Nutraceutical and pharmacy compounds Economical evaluations Business plan SWOT analysis Manufacturing costs High pressure Scale up Food regulations 


  1. Albuquerque CLC, Meireles MAA (2012) Defatting of annatto seeds using supercritical carbon dioxide as a pretreatment for the production of bixin: Experimental, modeling and economic evaluation of the process. J Supercrit Fluids 66:86–95CrossRefGoogle Scholar
  2. Alvarez L, Martın A, Sanjuan G, Calvo L (2009) Design and cost evaluation of a separation process for a multicomponent mixture using dense CO2. Ind Eng Chem Res 48:5779–5788CrossRefGoogle Scholar
  3. Billet R (1995) Packed towers in processing and environmental technology. VCH, WeinheimCrossRefGoogle Scholar
  4. Bravi M, Bubbico R, Manna F et al (2002) Process optimisation in sunflower oil extraction by supercritical CO2. Chem Eng Sci 57:2753–2764CrossRefGoogle Scholar
  5. Brunner G (1994) Gas extraction: An introduction to fundamentals of supercritical fluids and the application to separation processes. Springer, New YorkCrossRefGoogle Scholar
  6. Brunner G (2005) Supercritical fluids: technology and application to food processing. J Food Eng 67:21–33CrossRefGoogle Scholar
  7. Brunner G (2012) Supercritical fluids for effective separation processes. In: Proceedings on the 10th International symposium on supercritical fluids, San FranciscoGoogle Scholar
  8. Brunner G, Machado NT (2012) Process design methodology for fractionation of fatty acids from palm fatty acid distillates in countercurrent packed columns with supercritical CO2. J Supercrit Fluids 66:96–110CrossRefGoogle Scholar
  9. Budich M, Brunner G (2003) Supercritical fluid extraction of ethanol from aqueous solutions. J Supercrit Fluids 25:45–55CrossRefGoogle Scholar
  10. Caputo G, Gracia I, Saldana MDA et al (2013) Advances and perspectives of supercritical fluid technology. J Chemistry 2013:1–3CrossRefGoogle Scholar
  11. Codex Alimentarius (1999) Guidelines for the production, processing, labelling and marketing of organically produced foods GL 32-1999, pp 1–34, RomeGoogle Scholar
  12. Farías-Campomanes AM, Rostagno MA, Meireles MAA (2013) Production of polyphenol extracts from grape bagasse using supercritical fluids: Yield, extract composition and economic evaluation. J Supercrit Fluids 77:70–78CrossRefGoogle Scholar
  13. Fernández-Ronco MP, Gracia I (2011) Extraction of bioactive compounds from capsicum oleoresin. In: Salazar MA, Ortega JM (eds) Peppers: nutrition, consumption and health. Nova Science Publishers, Inc, New YorkGoogle Scholar
  14. Fernández-Ronco MP, Gracia I, Zetzl C et al (2011a) Equilibrium data for the separation of oleoresin capsicum using supercritical CO2: a theoretical design of a countercurrent gas extraction column. J Supercrit Fluids 57:1–8CrossRefGoogle Scholar
  15. Fernández-Ronco MP, Gracia I, De Lucas A et al (2011b) Measurement and modeling of the high-pressure phase equilibria of CO2-Oleoresin Capsicum. J Supercrit Fluids 57:112–119CrossRefGoogle Scholar
  16. Fernández-Ronco MP, Garcia MT, Rodriguez JF et al (2012) Economical analysis of the supercritical CO2 fractionation of capsicum liquid oleoresin. In: Proceedings on the 10th International symposium on supercritical fluids, San FranciscoGoogle Scholar
  17. Fernández-Ronco MP, Gracia I, de Lucas A et al (2013a) Extraction of Capsicum annuum oleoresin by maceration and ultrasound-assisted extraction: influence of parameters and process modeling. J Food Proc Eng 36:343–352CrossRefGoogle Scholar
  18. Fernández-Ronco MP, de Lucas A, Rodriguez JF et al (2013b) New considerations in the economic evaluation of supercritical processes: Separation of bioactive compounds from multicomponent mixtures. J Supercrit Fluids 79:345–355CrossRefGoogle Scholar
  19. Fiori L (2010) Supercritical extraction of grape seed oil at industrial-scale: plant and process design, modeling, economic feasibility. Chem Eng Proc 49:866–872CrossRefGoogle Scholar
  20. Gil-Chavez GJ, Villa JA, Ayala-Zavala JF et al (2013) Technologies for extraction and production of bioactive compounds to be used as nutraceuticals and food ingredients: an overview. Compr Rev Food Sci Food Saf 12:5–23CrossRefGoogle Scholar
  21. Gracia I (2011) La elaboración del plan de negocio. In: Lucas A (ed) Economía para la función directiva del Ingeniero Químico. SIGNE, Madrid, pp 421–466Google Scholar
  22. Gunasekaran A, Ngai EWT (2012) The future of operations management: an outlook and analysis. Int J Prod Econ 135(2):687–701Google Scholar
  23. Helfert EA (2001) Financial analysis tools and techniques. A guide for managers. McGraw-Hill, New York, p 40Google Scholar
  24. Herrero M, Cifuentes A, Ibanez E (2006) Sub- and supercritical fluid extraction of functional ingredients from different natural sources: plants, food-byproducts, algae and microalgae – a review. Food Chem 98:136–148CrossRefGoogle Scholar
  25. Hughes D (2009) European food marketing: understanding consumer wants – the starting point in adding value to basic food products. Euro Choices 8:6–13Google Scholar
  26. Johnston KP, Penninger JML (1989) Supercritical fluid science and technology. ACS, Washington, DCCrossRefGoogle Scholar
  27. King JW, Srinivas K, Dongfang Z (2011) Advances in critical fluid processing. In: Proctor A (ed) Alternatives to conventional food processing. Royal Society of Chemistry, Cambridge, pp 93–144Google Scholar
  28. Lack E, Gamse T, Marr R (2001) Separation operations and equipment. In: Bertucco A, Vetter G (eds) High pressure process technology. Elsevier, Amsterdam, The Netherlands, p 383Google Scholar
  29. Lee Y W (2012) Supercritical fluid technology- key to the future. In: Proceedings on the 10th International symposium on supercritical fluids, San FranciscoGoogle Scholar
  30. Leitao NCMCS, Prado GHC, Veggi PC et al (2013) Anacardiumoccidentale L. leaves extraction via SFE: global yields, extraction kinetics, mathematical modeling and economic evaluation. J Supercrit Fluids 78:114–123CrossRefGoogle Scholar
  31. Mark-Herbert C (2004) Innovation of a new product category—functional foods. Technovation 24:713–719CrossRefGoogle Scholar
  32. Melo MMR, Barbosa HMA, Passos CP et al (2014) Supercritical fluid extraction of spent coffee grounds: measurement of extraction curves, oil characterization and economic analysis. J Supercrit Fluids 86:150–159CrossRefGoogle Scholar
  33. Mendes MF, Pessoa FLP, Uller AMC (2002) An economic evaluation based on an experimental study of the vitamin E concentration present in deodorizer distillate of soybean oil using supercritical CO2. J Supercrit Fluids 23:257–265CrossRefGoogle Scholar
  34. Mezzomo N, Martínez J, Ferreira SRS (2011) Economical viability of SFE from peach almond, spearmint and marigold. J Food Eng 103:473–479CrossRefGoogle Scholar
  35. Mezzomo N, Martínez J, Maraschin M et al (2013) Pink shrimp (P. brasiliensis and P. paulensis) residue: supercritical fluid extraction of carotenoid fraction. J Supercrit Fluids 74:22–33CrossRefGoogle Scholar
  36. Mhurchu CN, Ogra S (2007) The price of healthy eating: cost and nutrient value of selected regular and healthier supermarket foods in New Zealand. N Z Med J 120:1248–1255Google Scholar
  37. Montanes F, Fornari T, Olano A et al (2012) Isolation of prebiotic carbohydrates by supercritical fluid extraction. Scaling-up and economical feasibility. J Chromatogr A 1250:92–98CrossRefGoogle Scholar
  38. Pereira CG, Meireles MAA (2010) Supercritical fluid extraction of bioactive compounds: fundamentals, applications and economic perspectives. Food Bioproc Technol 3:340–372CrossRefGoogle Scholar
  39. Perez-Silvestre V (2010) Plan financiero EOI. Business SchoolGoogle Scholar
  40. Perrut M (2000) Supercritical fluid applications: industrial developments and economic issues. Ind Eng Chem Res 39:4531–4535CrossRefGoogle Scholar
  41. Peters MS, Timmerhaus KD (1991) Plant design and economics for chemical engineers. McGraw Hill, London, pp 183, 202–203Google Scholar
  42. Prado JM, Assis AR, Maróstica-Júnior MR et al (2010) Manufacturing cost of supercritical-extracted oils and carotenoids from Amazonian plants. J Food Process Eng 33:348–369CrossRefGoogle Scholar
  43. Regulation (EC) n° 1924/2006 of the European Parliament and of the Council of 20 December 2006Google Scholar
  44. Reutersward AL (2007) The new EC regulation on nutrition and health claims on foods. Scand J Food Nutr 51(3):100–106CrossRefGoogle Scholar
  45. Roberts MT, Leibovitch EH (2011) Comparison of EU and US law on sustainable food processing. In: Proctor A (ed) Alternatives to conventional food processing. Royal Society of Chemistry, Cambridge, pp 11–92Google Scholar
  46. Rosa PTV, Meireles MAA (2005) Rapid estimation of the manufacturing cost of extracts obtained by supercritical fluid extraction. J Food Eng 67:235–240CrossRefGoogle Scholar
  47. Seidlitz H, Lack E, Fernandes JB et al (2013) NatexProzesstechnologie GesmbH, AustriaGoogle Scholar
  48. Shariaty-Niassar M, Aminzadeh B, Azadi P et al (2009) Economic evaluation of herb extraction. Chem Ind Chem Eng Quart 15(3):143–148CrossRefGoogle Scholar
  49. Steenhuis IHM, Waterlander WE, de Mul A (2011) Consumer food choices: the role of price and pricing strategies. Public Health Nutr 14:2220–2226CrossRefGoogle Scholar
  50. Stockfleth R, Brunner G (2001) Holdup, pressure drop, and flooding in packed countercurrent columns for the gas extraction. Ind Eng Chem Res 40:347–356CrossRefGoogle Scholar
  51. Turton R, Bailie RC, Whiting WB et al (1993) Analysis, synthesis, and design of chemical process. PTR, Prentice Hall, Upper Saddle RiverGoogle Scholar
  52. Valle JM, Aguilera JM (1988) An improved equation for predicting the solubility of vegetable oils in supercritical CO2. Ind Eng Chem Res 27:1551–1553CrossRefGoogle Scholar
  53. Accessed 15 Jan 2014
  54. Accessed 1 Apr 2014
  55. Accessed 1 Jan 2014

Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Department of Chemical EngineeringUniversity of Castilla La ManchaCiudad Real (España)Spain

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