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Abstract

We have conducted a systematic qualitative review on the pharmacokinetic and pharmacodynamic drug-drug interactions associated with antimalarial agents recommended by the World Health Organization. In this review, we have identified a few limitations in the available literature. These limitations, as well as suggested future experiments to overcome these shortcomings, are summarized below.

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References

  • Binh VQ, Chinh NT, Thanh NX et al (2009) Sex affects the steady-state pharmacokinetics of primaquine but not doxycycline in healthy subjects. Am J Trop Med Hyg 81(5):747–753

    Article  CAS  PubMed  Google Scholar 

  • Birkett DJ, Rees D, Andersson T et al (1994) In vitro proguanil activation to cycloguanil by human liver microsomes is mediated by CYP3A isoforms as well as by S-mephenytoin hydroxylase. Br J Clin Pharmacol 37(5):413–420

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Coller JK, Somogyi AA, Bochner F (1999) Comparison of (S)-mephenytoin and proguanil oxidation in vitro: contribution of several CYP isoforms. Br J Clin Pharmacol 48(2):158–167

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Kiang TK, Sherwin CM, Spigarelli MG et al (2012) Fundamentals of population pharmacokinetic modelling: modelling and software. Clin Pharmacokinet 51(8):515–525

    Article  CAS  PubMed  Google Scholar 

  • Lefevre G, Bindschedler M, Ezzet F et al (2000) Pharmacokinetic interaction trial between co-artemether and mefloquine. Eur J Pharm Sci 10(2):141–151

    Article  CAS  PubMed  Google Scholar 

  • Lu AH, Shu Y, Huang SL et al (2000) In vitro proguanil activation to cycloguanil is mediated by CYP2C19 and CYP3A4 in adult Chinese liver microsomes. Acta Pharmacol Sin 21(8):747–752

    CAS  PubMed  Google Scholar 

  • Na-Bangchang K, Karbwang J, Molunto P et al (1995) Pharmacokinetics of mefloquine, when given alone and in combination with artemether, in patients with uncomplicated falciparum malaria. Fundam Clin Pharmacol 9(6):576–582

    Article  CAS  PubMed  Google Scholar 

  • Teja-Isavadharm P, Watt G, Eamsila C et al (2001) Comparative pharmacokinetics and effect kinetics of orally administered artesunate in healthy volunteers and patients with uncomplicated falciparum malaria. Am J Trop Med Hyg 65(6):717–721

    CAS  PubMed  Google Scholar 

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Kiang, T.K.L., Wilby, K.J., Ensom, M.H.H. (2015). Limitations, Future Directions, and Conclusions. In: Clinical Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antimalarials. Adis, Cham. https://doi.org/10.1007/978-3-319-10527-7_8

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  • DOI: https://doi.org/10.1007/978-3-319-10527-7_8

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  • Publisher Name: Adis, Cham

  • Print ISBN: 978-3-319-10526-0

  • Online ISBN: 978-3-319-10527-7

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