Tensor Total-Variation Regularized Deconvolution for Efficient Low-Dose CT Perfusion

  • Ruogu Fang
  • Pina C. Sanelli
  • Shaoting Zhang
  • Tsuhan Chen
Part of the Lecture Notes in Computer Science book series (LNCS, volume 8673)


Acute brain diseases such as acute stroke and transit ischemic attacks are the leading causes of mortality and morbidity worldwide, responsible for 9% of total death every year. ‘Time is brain’ is a widely accepted concept in acute cerebrovascular disease treatment. Efficient and accurate computational framework for hemodynamic parameters estimation can save critical time for thrombolytic therapy. Meanwhile the high level of accumulated radiation dosage due to continuous image acquisition in CT perfusion (CTP) raised concerns on patient safety and public health. However, low-radiation will lead to increased noise and artifacts which require more sophisticated and time-consuming algorithms for robust estimation. We propose a novel efficient framework using tensor total-variation (TTV) regularization to achieve both high efficiency and accuracy in deconvolution for low-dose CTP. The method reduces the necessary radiation dose to only 8% of the original level and outperforms the state-of-art algorithms with estimation error reduced by 40%. It also corrects over-estimation of cerebral blood flow (CBF) and under-estimation of mean transit time (MTT), at both normal and reduced sampling rate. An efficient computational algorithm is proposed to find the solution with fast convergence.


Cerebral Blood Flow Mean Transit Time Compute Tomography Perfusion Baseline Method Perfusion Parameter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Ruogu Fang
    • 1
  • Pina C. Sanelli
    • 2
    • 3
  • Shaoting Zhang
    • 4
  • Tsuhan Chen
    • 1
  1. 1.Department of Electrical and Computer EngineeringCornell UniversityIthacaUSA
  2. 2.Department of RadiologyWeill Cornell Medical CollegeNew YorkUSA
  3. 3.Department of Public HealthWeill Cornell Medical CollegeNew YorkUSA
  4. 4.Department of Computer ScienceUniversity of North Carolina at CharlotteCharlotteUSA

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