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Hydrodynamic Damage to Animal Cells

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Animal Cell Culture

Part of the book series: Cell Engineering ((CEEN,volume 9))

Abstract

Large scale, animal cell culture in stirred tank bioreactors, is responsible for greater than &100 billion in sales of human biopharmaceuticals. This success was achieved in spite of the concern of the “shear sensitivity” of animal cells. In this contribution, a summary of the current state of this “shear sensitivity” concern will be discussed, demonstrating that it is not in general a problem with current bioprocess. Example of what is considered the current limits above which effects of hydrodynamic and interfacial concerns begin to negatively impact bioprocesses will also be presented.

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Authors and Affiliations

  1. William G Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, 43210, USA

    Jeffrey J. Chalmers

  2. Shenzhen Biopharmaceutical Research Institute, Shengyang Pharmaceutical University, Shenyang, China

    Ningning Ma

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  1. Jeffrey J. Chalmers
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  2. Ningning Ma
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Correspondence to Jeffrey J. Chalmers .

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Editors and Affiliations

  1. University College Dublin, Dublin, Ireland

    Mohamed Al-Rubeai

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© 2015 Springer International Publishing Switzerland

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Chalmers, J.J., Ma, N. (2015). Hydrodynamic Damage to Animal Cells. In: Al-Rubeai, M. (eds) Animal Cell Culture. Cell Engineering, vol 9. Springer, Cham. https://doi.org/10.1007/978-3-319-10320-4_6

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