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Reverse Pharmacognosy: A Tool to Accelerate the Discovery of New Bioactive Food Ingredients

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Foodinformatics

Abstract

In the developed countries, life expectancy has increased dramatically, especially during the past few decades. However, in addition to living longer, people also wish to remain healthy in old age. Functional food may help to achieve this desire. Consequently, there are a lot of opportunities in the development of bioactive ingredients which promote health and wellness. Naturally, this must be achieved with consumers’ safety in mind. One possible way to balance innovation hurdle and safety is to repurpose known molecules. Candidates may be innocuous natural products from edible sources, or molecules from the Generally Recognized as Safe (GRAS) list. Here, we describe the use of reverse pharmacognosy, and particularly our in silico approach with SelnergyTM, to accelerate the discovery of new applications for existing food ingredients, either per se or as possible starting points in the development of new but related molecules. We describe examples of natural substances and GRAS flavor molecules, with an emphasis on anti-inflammatory effects.

Dedication—This chapter is dedicated to the memory of John Sciré, who sadly passed away in November 2013. It was largely through his efforts and his enthusiasm that work on the flavorings was able to be undertaken.

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Acknowledgments

The authors wish to thank Robertet Flavors for permission to publish this work, and also Peter Lombardo for carefully reading through the manuscript and for making valuable suggestions.

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Authors and Affiliations

  1. Greenpharma, S.A.S, 3, allée du Titane, 45100, Orléans, France

    Quoc Tuan Do & Philippe Bernard

  2. Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, 7 Greenhouse Road, 02881, Kingston, RI, USA

    Maureen Driscoll, Angela Slitt & Navindra Seeram

  3. Robertet Flavors Inc., 10 Colonial Dr., 08854, Piscataway, NJ, USA

    Terry L. Peppard

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  1. Quoc Tuan Do
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  2. Maureen Driscoll
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Correspondence to Quoc Tuan Do .

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Editors and Affiliations

  1. Universidad Nacional Autónoma de México Instituto de Química, Mexico City, Mexico

    Karina Martinez-Mayorga

  2. Universidad Nacional Autónoma de México Instituto de Química, Mexico City, Mexico

    José Luis Medina-Franco

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Do, Q., Driscoll, M., Slitt, A., Seeram, N., Peppard, T., Bernard, P. (2014). Reverse Pharmacognosy: A Tool to Accelerate the Discovery of New Bioactive Food Ingredients. In: Martinez-Mayorga, K., Medina-Franco, J. (eds) Foodinformatics. Springer, Cham. https://doi.org/10.1007/978-3-319-10226-9_4

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