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Stearoyl-CoA Desaturases are Regulators of Lipid Metabolism in Skin

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Book cover Lipids and Skin Health

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Abstract

The skin is the largest single organ in humans, serving as a major barrier to infection, water loss, and abrasion. Skin is a stratified tissue composed of epidermis, dermis, and subcutaneous fat layers. The epidermis is the thinnest of the three layers but is the mitotically most active stratum due to the continued differentiation of keratinocytes into the cornified epithelium exposed to the environment. The dermis is thicker than the epidermis and contains a number of specialized structures such as sweat glands, hair follicles, and sebaceous glands that impart functional diversity to the organ. This layer functions as an insulator, shock absorber, and energy storage depot.

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Acknowledgements

Our research has been supported by NIH grant NIDDK-RO162388, AHA Grant-in Aid, Wisconsin Affiliate, USDA (Hatch) grant # 142-4306.

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  1. Department of Biochemistry and of Nutritional Sciences, University of Wisconsin-Madison, 53706, Madison, WI, USA

    James M. Ntambi

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  1. James M. Ntambi
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Correspondence to James M. Ntambi .

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  1. Johnson & Johnson, Skillman, New Jersey, USA

    Apostolos Pappas

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Ntambi, J. (2015). Stearoyl-CoA Desaturases are Regulators of Lipid Metabolism in Skin. In: Pappas, A. (eds) Lipids and Skin Health. Springer, Cham. https://doi.org/10.1007/978-3-319-09943-9_15

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