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Lipid- and Polymer-Based Drug Delivery Carriers for Eradicating Microbial Biofilms Causing Medical Device-Related Infections

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Biofilm-based Healthcare-associated Infections

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 831))

Abstract

The medical devices when they implanted or inserted into human body become the sites of competition between host cell integration and microbial adhesion while exerting the intended purpose like salvage of normal functions of vital organs. Different approaches either to enhance the efficiency of certain antimicrobial agents or to disrupt the basic physiology of the pathogenic microorganisms, including novel small molecules and antipathogenic drugs are already being employed to control microbial colonization and subsequent biofilm formation onto the medical devices. Recently, various lipid-and polymer-based drug delivery carriers are also investigated for applying antibiofilm coating onto the medical devices especially over catheters. To ensure systematic release of antimicrobial agents into the surrounding vicinity of an implanted medical device and, furthermore, provide sufficient initial and subsequent antimicrobial substance release, the antimicrobial substance are being incorporated into a controlled releasing polymer system, and then used to coat over medical devices. This book chapter summarizes the major and/breakthrough inventions disclosed in patent literature as well as in research papers showing the potential of lipid-and polymer-based drug delivery carriers to eradicate microbial biofilm causing medical device-related infections. With this coverage, this book chapter therefore provides a range of lipid and polymer-based drug delivery carrier is available for the medical scientist to develop a medical device with antibiofilm property.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India

    Tamilvanan Shunmugaperumal & Varinder Kaur

  2. Sankaralingam Bhuvaneswari College of Pharmacy, Sivakasi, TN, India

    Raja Sekharan Thenrajan

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  1. Tamilvanan Shunmugaperumal
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  2. Varinder Kaur
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  3. Raja Sekharan Thenrajan
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Correspondence to Tamilvanan Shunmugaperumal .

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  1. Fondazione Santa Lucia IRCCS, Microbial Biofilm Laboratory, Rome, Italy

    Gianfranco Donelli

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Shunmugaperumal, T., Kaur, V., Thenrajan, R.S. (2015). Lipid- and Polymer-Based Drug Delivery Carriers for Eradicating Microbial Biofilms Causing Medical Device-Related Infections. In: Donelli, G. (eds) Biofilm-based Healthcare-associated Infections. Advances in Experimental Medicine and Biology, vol 831. Springer, Cham. https://doi.org/10.1007/978-3-319-09782-4_10

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