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Fabrication of Polymer and Composite Scaffolds Using Electrospinning Techniques

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Composite Synthetic Scaffolds for Tissue Engineering and Regenerative Medicine

Part of the book series: SpringerBriefs in Materials ((BRIEFSMATERIALS))

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Abstract

This chapter reports the electrospinning technique for the formation of nano and microfibers. Due to the ability to fabricate fibrous scaffolds with micro and nano-scale properties, electrospinning technique has received much interest. Poly(caprolactone) (PCL) fibrous scaffolds with micro and nano-scale fibers and surface-porous fibers have not been explicitly investigated. In this study, the results of modulating the factors on processing route on nanofibrous scaffold morphology were investigated. 10 and 13 % w/v of PCL/dichloromethane (DCM) or chloroform was used at different flow rate and applied voltage. The result shows that 13 % w/v of PCL/chloroform produced better fibers. The fibrous scaffolds had two different ranges of fiber diameters. Average fiber diameter in the higher range was 4.52 μm while average fiber diameter in the lower range was 440 nm. In vitro degradation study suggested slow degradability of PCL electrospun fibers. This chapter also reports the fabrication of hydroxyapatite/PCL microfibers and their characteristics.

Mohd Izzat Hassan, Mim Mim Lim and Naznin Sultana.

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Acknowledgment

The authors would like to acknowledge the Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia (UTM) for the lab facilities. This work was supported by research grants FRGS (vot no: 4F126), GUP Tier 1 (03 H13, 05H07). Authors also acknowledge the support provided by MOHE, RMC and UTM.

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Authors and Affiliations

  1. Department of Clinical Sciences, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia (UTM), 81310, Johor Bahru, Johor, Malaysia

    Naznin Sultana, Mohd Izzat Hassan & Mim Mim Lim

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  1. Naznin Sultana
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  2. Mohd Izzat Hassan
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  3. Mim Mim Lim
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Correspondence to Naznin Sultana .

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Sultana, N., Hassan, M.I., Lim, M.M. (2015). Fabrication of Polymer and Composite Scaffolds Using Electrospinning Techniques. In: Composite Synthetic Scaffolds for Tissue Engineering and Regenerative Medicine. SpringerBriefs in Materials. Springer, Cham. https://doi.org/10.1007/978-3-319-09755-8_3

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