Statistical Considerations

  • Thomas Catalano
Part of the SpringerBriefs in Pharmaceutical Science & Drug Development book series (BRIEFSPSDD)


This chapter on statistical considerations was included to review the basic statistical concepts and discuss the concepts such as Confidence Intervals, Significance, Repeatability, Intermediate Precision, Sample Replicates, Uncertainty Measurements, and Sampling Strategies which are relevant to the interpretation of the data and the basis for supporting the reliability and relevance of the data in forensic chemistry.


Standard Uncertainty Simple Random Sampling Intermediate Precision Method Precision Residual Standard Deviation 
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    Box GEP, Hunter WG, Hunter SJ (1978) Statistics for experimenters, an introduction to design, data analysis, and model building. Wiley, New YorkGoogle Scholar
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    Ellison SLR et al (2009) Practical statistics for the analytical scientist, 2nd edn. RSC, CambridgeGoogle Scholar
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    ISO Guide 98 (1995) Guide to the expression of uncertainty in measurements. International Organization for Standardization, GenevaGoogle Scholar
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    Catalano T (2013) Essential elements for a GMP analytical chemistry department. Springer, New YorkGoogle Scholar

Copyright information

© Thomas Catalano 2014

Authors and Affiliations

  • Thomas Catalano
    • 1
  1. 1.PharmChem Analytical Consultants, LLCBuffalo GroveUSA

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